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Gene: ZNF611 |
Gene summary for ZNF611 |
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Gene information | Species | Human | Gene symbol | ZNF611 | Gene ID | 81856 |
Gene name | zinc finger protein 611 | |
Gene Alias | ZNF611 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N823 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81856 | ZNF611 | RNA-P17T-P17T-2 | Human | Lung | IAC | 4.46e-03 | 7.83e-01 | 0.3371 |
81856 | ZNF611 | RNA-P17T-P17T-8 | Human | Lung | IAC | 9.91e-03 | 6.41e-01 | 0.3329 |
81856 | ZNF611 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.48e-08 | 4.01e-01 | -0.0166 |
81856 | ZNF611 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.74e-06 | 3.24e-01 | -0.0132 |
81856 | ZNF611 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.42e-06 | 3.14e-01 | -0.013 |
81856 | ZNF611 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.13e-06 | 3.60e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF611 | SNV | Missense_Mutation | c.373N>A | p.Leu125Ile | p.L125I | Q8N823 | protein_coding | tolerated(0.05) | benign(0.071) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | c.584N>T | p.Arg195Ile | p.R195I | Q8N823 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | rs758332045 | c.1551N>T | p.Lys517Asn | p.K517N | Q8N823 | protein_coding | deleterious(0.01) | benign(0.155) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF611 | SNV | Missense_Mutation | novel | c.365N>T | p.Arg122Ile | p.R122I | Q8N823 | protein_coding | tolerated(0.07) | possibly_damaging(0.655) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF611 | SNV | Missense_Mutation | c.1353N>T | p.Glu451Asp | p.E451D | Q8N823 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ZNF611 | SNV | Missense_Mutation | c.1169N>T | p.Arg390Ile | p.R390I | Q8N823 | protein_coding | tolerated(0.18) | benign(0.107) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | rs774974353 | c.1873A>G | p.Asn625Asp | p.N625D | Q8N823 | protein_coding | tolerated(0.21) | benign(0.075) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
ZNF611 | SNV | Missense_Mutation | c.1316N>T | p.Ser439Leu | p.S439L | Q8N823 | protein_coding | deleterious(0.02) | benign(0.275) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | c.2093G>A | p.Arg698Lys | p.R698K | Q8N823 | protein_coding | tolerated(0.15) | benign(0.026) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ZNF611 | SNV | Missense_Mutation | c.460G>T | p.Asp154Tyr | p.D154Y | Q8N823 | protein_coding | deleterious(0.01) | benign(0.039) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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