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Gene: ZNF586 |
Gene summary for ZNF586 |
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Gene information | Species | Human | Gene symbol | ZNF586 | Gene ID | 54807 |
Gene name | zinc finger protein 586 | |
Gene Alias | ZNF586 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NXT0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54807 | ZNF586 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.55e-09 | 4.74e-01 | -0.1954 |
54807 | ZNF586 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.91e-02 | 2.39e-01 | -0.1001 |
54807 | ZNF586 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.28e-03 | 3.91e-01 | -0.059 |
54807 | ZNF586 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.30e-04 | 4.46e-01 | -0.0842 |
54807 | ZNF586 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.51e-09 | 4.82e-01 | 0.0674 |
54807 | ZNF586 | A015-C-203 | Human | Colorectum | FAP | 2.09e-10 | -2.89e-01 | -0.1294 |
54807 | ZNF586 | A002-C-201 | Human | Colorectum | FAP | 1.57e-03 | -2.27e-01 | 0.0324 |
54807 | ZNF586 | A002-C-203 | Human | Colorectum | FAP | 2.21e-05 | -2.81e-01 | 0.2786 |
54807 | ZNF586 | A001-C-108 | Human | Colorectum | FAP | 4.34e-05 | -1.51e-01 | -0.0272 |
54807 | ZNF586 | A002-C-205 | Human | Colorectum | FAP | 7.46e-06 | -1.97e-01 | -0.1236 |
54807 | ZNF586 | A015-C-006 | Human | Colorectum | FAP | 1.14e-03 | -1.40e-01 | -0.0994 |
54807 | ZNF586 | A015-C-106 | Human | Colorectum | FAP | 2.56e-03 | -1.07e-01 | -0.0511 |
54807 | ZNF586 | A002-C-114 | Human | Colorectum | FAP | 5.78e-05 | -3.87e-02 | -0.1561 |
54807 | ZNF586 | A015-C-104 | Human | Colorectum | FAP | 1.37e-09 | -1.40e-01 | -0.1899 |
54807 | ZNF586 | A001-C-014 | Human | Colorectum | FAP | 1.12e-06 | -2.64e-01 | 0.0135 |
54807 | ZNF586 | A002-C-016 | Human | Colorectum | FAP | 3.65e-13 | -2.51e-01 | 0.0521 |
54807 | ZNF586 | A015-C-002 | Human | Colorectum | FAP | 4.90e-05 | -3.82e-01 | -0.0763 |
54807 | ZNF586 | A001-C-203 | Human | Colorectum | FAP | 4.45e-04 | -1.20e-01 | -0.0481 |
54807 | ZNF586 | A002-C-116 | Human | Colorectum | FAP | 1.52e-15 | -1.63e-01 | -0.0452 |
54807 | ZNF586 | A014-C-008 | Human | Colorectum | FAP | 3.52e-03 | -1.38e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF586 | SNV | Missense_Mutation | rs770528695 | c.818N>A | p.Arg273Gln | p.R273Q | Q9NXT0 | protein_coding | tolerated(1) | benign(0.061) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF586 | SNV | Missense_Mutation | novel | c.232G>T | p.Asp78Tyr | p.D78Y | Q9NXT0 | protein_coding | tolerated(0.64) | possibly_damaging(0.74) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF586 | insertion | Frame_Shift_Ins | novel | c.274dupG | p.Glu92GlyfsTer3 | p.E92Gfs*3 | Q9NXT0 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF586 | SNV | Missense_Mutation | novel | c.62C>T | p.Ala21Val | p.A21V | Q9NXT0 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF586 | SNV | Missense_Mutation | novel | c.485G>T | p.Ser162Ile | p.S162I | Q9NXT0 | protein_coding | tolerated(0.25) | benign(0.12) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF586 | SNV | Missense_Mutation | novel | c.209N>T | p.Ser70Ile | p.S70I | Q9NXT0 | protein_coding | tolerated(0.12) | benign(0.093) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF586 | SNV | Missense_Mutation | rs557538085 | c.127G>A | p.Val43Met | p.V43M | Q9NXT0 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF586 | SNV | Missense_Mutation | c.138N>T | p.Glu46Asp | p.E46D | Q9NXT0 | protein_coding | deleterious(0.04) | possibly_damaging(0.675) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF586 | SNV | Missense_Mutation | rs369596169 | c.1147N>T | p.Arg383Cys | p.R383C | Q9NXT0 | protein_coding | deleterious(0.01) | probably_damaging(0.93) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZNF586 | SNV | Missense_Mutation | novel | c.779N>T | p.Arg260Met | p.R260M | Q9NXT0 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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