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Gene: ZNF500 |
Gene summary for ZNF500 |
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Gene information | Species | Human | Gene symbol | ZNF500 | Gene ID | 26048 |
Gene name | zinc finger protein 500 | |
Gene Alias | ZKSCAN18 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60304 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26048 | ZNF500 | HCC1_Meng | Human | Liver | HCC | 3.14e-08 | -3.48e-02 | 0.0246 |
26048 | ZNF500 | HCC2_Meng | Human | Liver | HCC | 9.79e-03 | 5.68e-03 | 0.0107 |
26048 | ZNF500 | HCC1 | Human | Liver | HCC | 1.22e-05 | 1.14e+00 | 0.5336 |
26048 | ZNF500 | HCC2 | Human | Liver | HCC | 3.32e-16 | 1.57e+00 | 0.5341 |
26048 | ZNF500 | HCC5 | Human | Liver | HCC | 2.58e-07 | 2.14e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF500 | SNV | Missense_Mutation | novel | c.1116N>T | p.Gln372His | p.Q372H | O60304 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF500 | SNV | Missense_Mutation | novel | c.1115N>T | p.Gln372Leu | p.Q372L | O60304 | protein_coding | deleterious(0) | benign(0.384) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF500 | SNV | Missense_Mutation | c.678G>T | p.Leu226Phe | p.L226F | O60304 | protein_coding | tolerated(0.15) | benign(0.019) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
ZNF500 | SNV | Missense_Mutation | novel | c.206N>T | p.Ser69Ile | p.S69I | O60304 | protein_coding | tolerated(0.25) | probably_damaging(0.939) | TCGA-22-5481-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF500 | SNV | Missense_Mutation | c.364N>T | p.Val122Leu | p.V122L | O60304 | protein_coding | deleterious(0.01) | possibly_damaging(0.832) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF500 | SNV | Missense_Mutation | rs751834995 | c.809N>T | p.Pro270Leu | p.P270L | O60304 | protein_coding | tolerated(0.17) | benign(0) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF500 | SNV | Missense_Mutation | novel | c.136C>G | p.Pro46Ala | p.P46A | O60304 | protein_coding | deleterious(0.02) | possibly_damaging(0.901) | TCGA-CV-5435-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF500 | SNV | Missense_Mutation | c.985G>A | p.Glu329Lys | p.E329K | O60304 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
ZNF500 | SNV | Missense_Mutation | rs143815276 | c.1145N>T | p.Pro382Leu | p.P382L | O60304 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-D7-6815-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF500 | insertion | Frame_Shift_Ins | novel | c.1043_1044insAC | p.Gly349ArgfsTer9 | p.G349Rfs*9 | O60304 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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