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Gene: ZNF273 |
Gene summary for ZNF273 |
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Gene information | Species | Human | Gene symbol | ZNF273 | Gene ID | 10793 |
Gene name | zinc finger protein 273 | |
Gene Alias | HZF9 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14593 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10793 | ZNF273 | LZE4T | Human | Esophagus | ESCC | 1.22e-05 | 8.82e-02 | 0.0811 |
10793 | ZNF273 | LZE24T | Human | Esophagus | ESCC | 3.25e-10 | 2.52e-01 | 0.0596 |
10793 | ZNF273 | P1T-E | Human | Esophagus | ESCC | 2.83e-08 | 3.31e-01 | 0.0875 |
10793 | ZNF273 | P2T-E | Human | Esophagus | ESCC | 9.47e-18 | 3.23e-01 | 0.1177 |
10793 | ZNF273 | P4T-E | Human | Esophagus | ESCC | 8.74e-12 | 3.14e-01 | 0.1323 |
10793 | ZNF273 | P5T-E | Human | Esophagus | ESCC | 4.26e-14 | 2.47e-01 | 0.1327 |
10793 | ZNF273 | P8T-E | Human | Esophagus | ESCC | 2.23e-16 | 2.33e-01 | 0.0889 |
10793 | ZNF273 | P9T-E | Human | Esophagus | ESCC | 3.88e-07 | 1.37e-01 | 0.1131 |
10793 | ZNF273 | P10T-E | Human | Esophagus | ESCC | 4.94e-18 | 3.17e-01 | 0.116 |
10793 | ZNF273 | P12T-E | Human | Esophagus | ESCC | 2.21e-16 | 3.60e-01 | 0.1122 |
10793 | ZNF273 | P15T-E | Human | Esophagus | ESCC | 2.29e-12 | 2.57e-01 | 0.1149 |
10793 | ZNF273 | P16T-E | Human | Esophagus | ESCC | 5.67e-15 | 1.73e-01 | 0.1153 |
10793 | ZNF273 | P20T-E | Human | Esophagus | ESCC | 3.64e-09 | 2.29e-01 | 0.1124 |
10793 | ZNF273 | P21T-E | Human | Esophagus | ESCC | 4.65e-11 | 2.08e-01 | 0.1617 |
10793 | ZNF273 | P22T-E | Human | Esophagus | ESCC | 8.33e-12 | 2.33e-01 | 0.1236 |
10793 | ZNF273 | P23T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.16e-01 | 0.108 |
10793 | ZNF273 | P24T-E | Human | Esophagus | ESCC | 1.08e-08 | 6.19e-02 | 0.1287 |
10793 | ZNF273 | P26T-E | Human | Esophagus | ESCC | 9.57e-11 | 1.40e-01 | 0.1276 |
10793 | ZNF273 | P27T-E | Human | Esophagus | ESCC | 1.51e-18 | 3.37e-01 | 0.1055 |
10793 | ZNF273 | P28T-E | Human | Esophagus | ESCC | 1.77e-17 | 3.49e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF273 | SNV | Missense_Mutation | novel | c.134N>G | p.Glu45Gly | p.E45G | Q14593 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF273 | SNV | Missense_Mutation | novel | c.485N>A | p.Gly162Asp | p.G162D | Q14593 | protein_coding | tolerated(0.1) | benign(0.071) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF273 | SNV | Missense_Mutation | c.1097N>T | p.Arg366Ile | p.R366I | Q14593 | protein_coding | tolerated(0.49) | benign(0.021) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF273 | SNV | Missense_Mutation | c.1613N>A | p.Gly538Glu | p.G538E | Q14593 | protein_coding | tolerated(0.07) | benign(0.021) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF273 | SNV | Missense_Mutation | rs148564376 | c.458C>T | p.Ala153Val | p.A153V | Q14593 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZNF273 | SNV | Missense_Mutation | rs759921279 | c.570C>A | p.Phe190Leu | p.F190L | Q14593 | protein_coding | tolerated(0.17) | benign(0.111) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZNF273 | SNV | Missense_Mutation | c.1517G>T | p.Arg506Ile | p.R506I | Q14593 | protein_coding | tolerated(0.39) | benign(0.012) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF273 | SNV | Missense_Mutation | novel | c.719G>A | p.Gly240Glu | p.G240E | Q14593 | protein_coding | deleterious(0.03) | possibly_damaging(0.525) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF273 | SNV | Missense_Mutation | c.1410C>A | p.Phe470Leu | p.F470L | Q14593 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
ZNF273 | SNV | Missense_Mutation | novel | c.1610C>A | p.Thr537Asn | p.T537N | Q14593 | protein_coding | deleterious(0) | benign(0.328) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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