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Gene: ZNF217 |
Gene summary for ZNF217 |
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Gene information | Species | Human | Gene symbol | ZNF217 | Gene ID | 7764 |
Gene name | zinc finger protein 217 | |
Gene Alias | ZABC1 | |
Cytomap | 20q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75362 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7764 | ZNF217 | GSM4909293 | Human | Breast | IDC | 3.14e-02 | 1.67e-01 | 0.1581 |
7764 | ZNF217 | GSM4909301 | Human | Breast | IDC | 7.26e-04 | 3.41e-01 | 0.1577 |
7764 | ZNF217 | GSM4909311 | Human | Breast | IDC | 3.80e-05 | -1.66e-01 | 0.1534 |
7764 | ZNF217 | GSM4909317 | Human | Breast | IDC | 1.22e-15 | 5.34e-01 | 0.1355 |
7764 | ZNF217 | GSM4909318 | Human | Breast | IDC | 4.88e-09 | 8.51e-01 | 0.2031 |
7764 | ZNF217 | GSM4909319 | Human | Breast | IDC | 3.18e-07 | -1.53e-01 | 0.1563 |
7764 | ZNF217 | M1 | Human | Breast | IDC | 2.16e-07 | 4.09e-01 | 0.1577 |
7764 | ZNF217 | NCCBC2 | Human | Breast | DCIS | 5.09e-06 | 6.85e-01 | 0.1554 |
7764 | ZNF217 | DCIS2 | Human | Breast | DCIS | 6.43e-42 | 2.01e-01 | 0.0085 |
7764 | ZNF217 | LZE4T | Human | Esophagus | ESCC | 1.04e-20 | 9.66e-01 | 0.0811 |
7764 | ZNF217 | LZE5T | Human | Esophagus | ESCC | 4.77e-06 | 5.35e-01 | 0.0514 |
7764 | ZNF217 | LZE7T | Human | Esophagus | ESCC | 6.64e-12 | 8.71e-01 | 0.0667 |
7764 | ZNF217 | LZE20T | Human | Esophagus | ESCC | 7.15e-10 | 3.43e-01 | 0.0662 |
7764 | ZNF217 | LZE22T | Human | Esophagus | ESCC | 1.27e-02 | 3.51e-01 | 0.068 |
7764 | ZNF217 | LZE24T | Human | Esophagus | ESCC | 2.81e-14 | 5.20e-01 | 0.0596 |
7764 | ZNF217 | LZE21T | Human | Esophagus | ESCC | 1.64e-08 | 5.00e-01 | 0.0655 |
7764 | ZNF217 | LZE6T | Human | Esophagus | ESCC | 7.34e-03 | 1.12e-01 | 0.0845 |
7764 | ZNF217 | P1T-E | Human | Esophagus | ESCC | 9.10e-09 | 4.60e-01 | 0.0875 |
7764 | ZNF217 | P2T-E | Human | Esophagus | ESCC | 2.14e-22 | 4.17e-01 | 0.1177 |
7764 | ZNF217 | P4T-E | Human | Esophagus | ESCC | 7.46e-28 | 9.48e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF217 | SNV | Missense_Mutation | c.2948N>C | p.Val983Ala | p.V983A | O75362 | protein_coding | tolerated(0.1) | possibly_damaging(0.6) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF217 | SNV | Missense_Mutation | novel | c.419N>A | p.Ala140Asp | p.A140D | O75362 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF217 | SNV | Missense_Mutation | rs758311512 | c.2011G>A | p.Ala671Thr | p.A671T | O75362 | protein_coding | tolerated(0.52) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF217 | SNV | Missense_Mutation | c.3091A>C | p.Asn1031His | p.N1031H | O75362 | protein_coding | deleterious(0.02) | possibly_damaging(0.754) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF217 | SNV | Missense_Mutation | c.593N>A | p.Thr198Lys | p.T198K | O75362 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ZNF217 | SNV | Missense_Mutation | rs371730112 | c.2969A>G | p.Tyr990Cys | p.Y990C | O75362 | protein_coding | deleterious(0.02) | possibly_damaging(0.781) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF217 | SNV | Missense_Mutation | rs766424905 | c.418G>A | p.Ala140Thr | p.A140T | O75362 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
ZNF217 | SNV | Missense_Mutation | rs112155907 | c.2656G>A | p.Ala886Thr | p.A886T | O75362 | protein_coding | tolerated(0.39) | benign(0.024) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF217 | SNV | Missense_Mutation | c.2596N>A | p.Val866Ile | p.V866I | O75362 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF217 | SNV | Missense_Mutation | c.2290G>T | p.Asp764Tyr | p.D764Y | O75362 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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