TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF121 | TH1 | Colorectum | AD | GIMAP4,FOS,TRAPPC4, etc. | 1.54e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_AD/regulons_activity_in_dotplot.png) |
ZNF121 | TH1 | Colorectum | MSI-H | GIMAP4,FOS,TRAPPC4, etc. | 2.01e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF121 | GC | Colorectum | SER | GIMAP4,FOS,TRAPPC4, etc. | 2.65e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_SER/regulons_activity_in_dotplot.png) |
ZNF121 | CD8TEFF | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF121 | NEUT | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -2.22e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF121 | TH1 | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -4.44e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF121 | CD4TN | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF121 | CD8TEREX | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -4.44e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF121 | CD4TN | Endometrium | AEH | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
ZNF121 | MAST | Endometrium | AEH | LUZP1,STK38L,TMEM164, etc. | 1.36e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF121 | SNV | Missense_Mutation | novel | c.838N>A | p.Gly280Arg | p.G280R | P58317 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | | c.121N>C | p.Cys41Arg | p.C41R | P58317 | protein_coding | tolerated(0.21) | possibly_damaging(0.866) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | | c.883G>A | p.Val295Ile | p.V295I | P58317 | protein_coding | tolerated(0.47) | possibly_damaging(0.484) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | | c.663A>G | p.Ile221Met | p.I221M | P58317 | protein_coding | deleterious(0.02) | probably_damaging(0.944) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.91N>A | p.Gly31Arg | p.G31R | P58317 | protein_coding | tolerated(1) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.1153A>C | p.Lys385Gln | p.K385Q | P58317 | protein_coding | tolerated(0.31) | benign(0.101) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | | c.491N>A | p.Arg164Gln | p.R164Q | P58317 | protein_coding | tolerated(0.34) | benign(0.257) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ZNF121 | SNV | Missense_Mutation | novel | c.854N>C | p.Lys285Thr | p.K285T | P58317 | protein_coding | tolerated(0.58) | benign(0.092) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.59N>C | p.Phe20Ser | p.F20S | P58317 | protein_coding | tolerated(0.07) | benign(0.132) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.293N>C | p.Val98Ala | p.V98A | P58317 | protein_coding | tolerated(0.38) | benign(0.07) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |