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Gene: ZNF106 |
Gene summary for ZNF106 |
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Gene information | Species | Human | Gene symbol | ZNF106 | Gene ID | 64397 |
Gene name | zinc finger protein 106 | |
Gene Alias | SH3BP3 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A0C4DGM5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64397 | ZNF106 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.47e-03 | 1.77e-01 | -0.0811 |
64397 | ZNF106 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.02e-07 | 4.37e-01 | -0.1954 |
64397 | ZNF106 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.23e-03 | 3.00e-01 | -0.1464 |
64397 | ZNF106 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.02e-03 | 2.51e-01 | -0.1001 |
64397 | ZNF106 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.28e-04 | 2.98e-01 | 0.0674 |
64397 | ZNF106 | F007 | Human | Colorectum | FAP | 1.61e-03 | -3.11e-01 | 0.1176 |
64397 | ZNF106 | A015-C-203 | Human | Colorectum | FAP | 6.58e-08 | -2.02e-01 | -0.1294 |
64397 | ZNF106 | A002-C-201 | Human | Colorectum | FAP | 1.63e-03 | -1.10e-01 | 0.0324 |
64397 | ZNF106 | A001-C-108 | Human | Colorectum | FAP | 2.13e-02 | -8.74e-02 | -0.0272 |
64397 | ZNF106 | A002-C-205 | Human | Colorectum | FAP | 1.29e-07 | -9.82e-02 | -0.1236 |
64397 | ZNF106 | A015-C-006 | Human | Colorectum | FAP | 3.27e-04 | -1.25e-01 | -0.0994 |
64397 | ZNF106 | A015-C-106 | Human | Colorectum | FAP | 3.67e-03 | -2.72e-02 | -0.0511 |
64397 | ZNF106 | A002-C-114 | Human | Colorectum | FAP | 1.83e-04 | -1.32e-01 | -0.1561 |
64397 | ZNF106 | A015-C-104 | Human | Colorectum | FAP | 2.36e-08 | -1.64e-01 | -0.1899 |
64397 | ZNF106 | A002-C-016 | Human | Colorectum | FAP | 2.08e-07 | -2.01e-01 | 0.0521 |
64397 | ZNF106 | A015-C-002 | Human | Colorectum | FAP | 2.29e-03 | -1.91e-01 | -0.0763 |
64397 | ZNF106 | A002-C-116 | Human | Colorectum | FAP | 4.40e-11 | -1.19e-01 | -0.0452 |
64397 | ZNF106 | A014-C-008 | Human | Colorectum | FAP | 3.04e-04 | -1.32e-01 | -0.191 |
64397 | ZNF106 | A018-E-020 | Human | Colorectum | FAP | 2.11e-06 | 3.32e-03 | -0.2034 |
64397 | ZNF106 | F034 | Human | Colorectum | FAP | 7.50e-05 | -9.21e-02 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:00434343 | Colorectum | FAP | response to peptide hormone | 100/2622 | 414/18723 | 1.74e-08 | 1.84e-06 | 100 |
GO:19016533 | Colorectum | FAP | cellular response to peptide | 89/2622 | 359/18723 | 2.93e-08 | 2.64e-06 | 89 |
GO:00713753 | Colorectum | FAP | cellular response to peptide hormone stimulus | 75/2622 | 290/18723 | 5.60e-08 | 4.29e-06 | 75 |
GO:00328683 | Colorectum | FAP | response to insulin | 68/2622 | 264/18723 | 2.71e-07 | 1.55e-05 | 68 |
GO:00328693 | Colorectum | FAP | cellular response to insulin stimulus | 54/2622 | 203/18723 | 1.54e-06 | 6.59e-05 | 54 |
GO:0008286 | Colorectum | FAP | insulin receptor signaling pathway | 28/2622 | 116/18723 | 2.37e-03 | 1.89e-02 | 28 |
GO:00434344 | Colorectum | CRC | response to peptide hormone | 76/2078 | 414/18723 | 6.67e-06 | 2.56e-04 | 76 |
GO:00328684 | Colorectum | CRC | response to insulin | 53/2078 | 264/18723 | 1.30e-05 | 4.17e-04 | 53 |
GO:00328694 | Colorectum | CRC | cellular response to insulin stimulus | 42/2078 | 203/18723 | 4.79e-05 | 1.12e-03 | 42 |
GO:00713754 | Colorectum | CRC | cellular response to peptide hormone stimulus | 55/2078 | 290/18723 | 4.82e-05 | 1.12e-03 | 55 |
GO:19016534 | Colorectum | CRC | cellular response to peptide | 64/2078 | 359/18723 | 8.54e-05 | 1.75e-03 | 64 |
GO:00082861 | Colorectum | CRC | insulin receptor signaling pathway | 23/2078 | 116/18723 | 4.02e-03 | 3.33e-02 | 23 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF106 | SNV | Missense_Mutation | novel | c.2865N>C | p.Leu955Phe | p.L955F | Q9H2Y7 | protein_coding | tolerated(0.57) | benign(0.166) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF106 | SNV | Missense_Mutation | rs770514798 | c.3496N>T | p.His1166Tyr | p.H1166Y | Q9H2Y7 | protein_coding | tolerated(0.19) | possibly_damaging(0.737) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF106 | SNV | Missense_Mutation | novel | c.4755G>C | p.Lys1585Asn | p.K1585N | Q9H2Y7 | protein_coding | tolerated(0.06) | probably_damaging(0.984) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZNF106 | SNV | Missense_Mutation | novel | c.64N>A | p.Glu22Lys | p.E22K | protein_coding | deleterious(0.03) | benign(0.102) | TCGA-VS-A9V4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF106 | SNV | Missense_Mutation | rs749272671 | c.4517N>T | p.Ser1506Leu | p.S1506L | Q9H2Y7 | protein_coding | deleterious(0.05) | possibly_damaging(0.656) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF106 | SNV | Missense_Mutation | rs201999471 | c.1039C>T | p.Arg347Cys | p.R347C | Q9H2Y7 | protein_coding | tolerated(0.15) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF106 | SNV | Missense_Mutation | c.4997N>G | p.Gln1666Arg | p.Q1666R | Q9H2Y7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF106 | SNV | Missense_Mutation | novel | c.5618N>A | p.Arg1873Gln | p.R1873Q | Q9H2Y7 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF106 | SNV | Missense_Mutation | rs768526330 | c.2135N>T | p.Ser712Leu | p.S712L | Q9H2Y7 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF106 | SNV | Missense_Mutation | rs772280487 | c.1501N>T | p.Pro501Ser | p.P501S | Q9H2Y7 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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