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Gene: ZHX3 |
Gene summary for ZHX3 |
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Gene information | Species | Human | Gene symbol | ZHX3 | Gene ID | 23051 |
Gene name | zinc fingers and homeoboxes 3 | |
Gene Alias | TIX1 | |
Cytomap | 20q12 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9H4I2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23051 | ZHX3 | NAFLD1 | Human | Liver | NAFLD | 4.83e-12 | 1.05e+00 | -0.04 |
23051 | ZHX3 | HCC1_Meng | Human | Liver | HCC | 1.64e-36 | -1.06e-01 | 0.0246 |
23051 | ZHX3 | HCC2_Meng | Human | Liver | HCC | 6.44e-05 | -1.44e-01 | 0.0107 |
23051 | ZHX3 | HCC1 | Human | Liver | HCC | 1.29e-05 | 1.93e+00 | 0.5336 |
23051 | ZHX3 | HCC2 | Human | Liver | HCC | 1.52e-14 | 2.53e+00 | 0.5341 |
23051 | ZHX3 | HCC5 | Human | Liver | HCC | 1.49e-17 | 1.69e+00 | 0.4932 |
23051 | ZHX3 | Pt13.a | Human | Liver | HCC | 1.14e-03 | -1.83e-01 | 0.021 |
23051 | ZHX3 | Pt14.d | Human | Liver | HCC | 2.02e-03 | -1.71e-01 | 0.0143 |
23051 | ZHX3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.22e-06 | 3.72e-01 | -0.2116 |
23051 | ZHX3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.03e-08 | 5.80e-01 | -0.2119 |
23051 | ZHX3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.72e-05 | 3.20e-01 | -0.0166 |
23051 | ZHX3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.74e-06 | 2.76e-01 | -0.0132 |
23051 | ZHX3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.68e-06 | 2.59e-01 | -0.013 |
23051 | ZHX3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.51e-06 | 3.10e-01 | -0.0121 |
23051 | ZHX3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.48e-04 | 5.17e-01 | -0.0961 |
23051 | ZHX3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 6.55e-04 | 4.50e-01 | -0.0876 |
23051 | ZHX3 | HTA12-23-1 | Human | Pancreas | PDAC | 7.76e-05 | 5.79e-01 | 0.3405 |
23051 | ZHX3 | HTA12-26-1 | Human | Pancreas | PDAC | 5.33e-06 | 4.65e-01 | 0.3728 |
23051 | ZHX3 | HTA12-29-1 | Human | Pancreas | PDAC | 1.47e-33 | 7.11e-01 | 0.3722 |
23051 | ZHX3 | HTA12-9-2 | Human | Pancreas | PDAC | 2.02e-02 | 3.21e-01 | 0.0835 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000164911 | Liver | HCC | osteoblast differentiation | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:0001649111 | Thyroid | PTC | osteoblast differentiation | 102/5968 | 229/18723 | 3.66e-05 | 3.40e-04 | 102 |
GO:00456697 | Thyroid | PTC | positive regulation of osteoblast differentiation | 32/5968 | 69/18723 | 8.16e-03 | 3.44e-02 | 32 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:000164932 | Thyroid | ATC | osteoblast differentiation | 122/6293 | 229/18723 | 6.04e-10 | 1.60e-08 | 122 |
GO:004566721 | Thyroid | ATC | regulation of osteoblast differentiation | 66/6293 | 132/18723 | 7.03e-05 | 5.36e-04 | 66 |
GO:004566912 | Thyroid | ATC | positive regulation of osteoblast differentiation | 38/6293 | 69/18723 | 1.97e-04 | 1.31e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZHX3 | SNV | Missense_Mutation | c.2342N>G | p.Gln781Arg | p.Q781R | Q9H4I2 | protein_coding | tolerated(0.05) | possibly_damaging(0.76) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZHX3 | SNV | Missense_Mutation | novel | c.502C>T | p.Pro168Ser | p.P168S | Q9H4I2 | protein_coding | tolerated(0.73) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZHX3 | SNV | Missense_Mutation | novel | c.1811C>A | p.Ser604Tyr | p.S604Y | Q9H4I2 | protein_coding | deleterious(0.03) | possibly_damaging(0.832) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZHX3 | SNV | Missense_Mutation | rs780107331 | c.1201N>C | p.Asn401His | p.N401H | Q9H4I2 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
ZHX3 | SNV | Missense_Mutation | rs372943167 | c.2798N>A | p.Arg933His | p.R933H | Q9H4I2 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
ZHX3 | SNV | Missense_Mutation | novel | c.1342N>G | p.Thr448Ala | p.T448A | Q9H4I2 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZHX3 | SNV | Missense_Mutation | c.1627N>G | p.Ser543Gly | p.S543G | Q9H4I2 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZHX3 | SNV | Missense_Mutation | novel | c.536N>G | p.Ile179Ser | p.I179S | Q9H4I2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZHX3 | SNV | Missense_Mutation | c.835N>T | p.Pro279Ser | p.P279S | Q9H4I2 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZHX3 | SNV | Missense_Mutation | c.1954N>G | p.Thr652Ala | p.T652A | Q9H4I2 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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