GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:0051101111 | Esophagus | ESCC | regulation of DNA binding | 84/8552 | 118/18723 | 1.64e-08 | 3.21e-07 | 84 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:00433924 | Esophagus | ESCC | negative regulation of DNA binding | 37/8552 | 52/18723 | 1.75e-04 | 1.14e-03 | 37 |
GO:0051098113 | Thyroid | PTC | regulation of binding | 195/5968 | 363/18723 | 3.21e-18 | 3.37e-16 | 195 |
GO:0051101113 | Thyroid | PTC | regulation of DNA binding | 63/5968 | 118/18723 | 1.00e-06 | 1.50e-05 | 63 |
GO:0051100113 | Thyroid | PTC | negative regulation of binding | 81/5968 | 162/18723 | 1.14e-06 | 1.67e-05 | 81 |
GO:00433926 | Thyroid | PTC | negative regulation of DNA binding | 29/5968 | 52/18723 | 3.09e-04 | 2.15e-03 | 29 |
GO:005109834 | Thyroid | ATC | regulation of binding | 203/6293 | 363/18723 | 1.18e-18 | 1.55e-16 | 203 |
GO:005110027 | Thyroid | ATC | negative regulation of binding | 86/6293 | 162/18723 | 2.41e-07 | 3.73e-06 | 86 |
GO:005110133 | Thyroid | ATC | regulation of DNA binding | 64/6293 | 118/18723 | 3.10e-06 | 3.54e-05 | 64 |
GO:004339214 | Thyroid | ATC | negative regulation of DNA binding | 30/6293 | 52/18723 | 3.08e-04 | 1.94e-03 | 30 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZFP90 | MSC | Stomach | ADJ | MOK,AC026979.2,ZNF212, etc. | 4.73e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP90 | FIB | Stomach | ADJ | MOK,AC026979.2,ZNF212, etc. | 2.59e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP90 | MVA | Stomach | CAG with IM | MOK,AC026979.2,ZNF212, etc. | 1.12e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CAG with IM/regulons_activity_in_dotplot.png) |
ZFP90 | MSC | Stomach | CSG | MOK,AC026979.2,ZNF212, etc. | 3.95e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CSG/regulons_activity_in_dotplot.png) |
ZFP90 | MSC | Stomach | Healthy | MOK,AC026979.2,ZNF212, etc. | 1.89e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP90 | LYMEND | Stomach | Healthy | MOK,AC026979.2,ZNF212, etc. | 5.22e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP90 | NKT | Thyroid | ATC | COL1A2,P4HA2,MDK, etc. | 1.68e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
ZFP90 | CD8TEXINT | Thyroid | Healthy | COL1A2,P4HA2,MDK, etc. | 1.66e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP90 | TFH | Thyroid | HT | COL1A2,P4HA2,MDK, etc. | 1.74e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_HT/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP90 | insertion | Frame_Shift_Ins | novel | c.1845_1846insA | p.Asn617LysfsTer10 | p.N617Kfs*10 | Q8TF47 | protein_coding | | | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZFP90 | SNV | Missense_Mutation | rs749134459 | c.674N>T | p.Ser225Leu | p.S225L | Q8TF47 | protein_coding | tolerated(0.28) | possibly_damaging(0.838) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | novel | c.1559N>A | p.Thr520Asn | p.T520N | Q8TF47 | protein_coding | tolerated(0.05) | possibly_damaging(0.895) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | rs376305945 | c.1069N>A | p.Glu357Lys | p.E357K | Q8TF47 | protein_coding | tolerated(0.2) | benign(0.353) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | rs377592641 | c.1898N>A | p.Arg633Gln | p.R633Q | Q8TF47 | protein_coding | deleterious(0.02) | benign(0.255) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | rs777576155 | c.962N>A | p.Arg321His | p.R321H | Q8TF47 | protein_coding | tolerated(0.06) | benign(0.048) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZFP90 | SNV | Missense_Mutation | rs377592641 | c.1898G>A | p.Arg633Gln | p.R633Q | Q8TF47 | protein_coding | deleterious(0.02) | benign(0.255) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | | c.1802G>T | p.Arg601Ile | p.R601I | Q8TF47 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | novel | c.393G>T | p.Gln131His | p.Q131H | Q8TF47 | protein_coding | tolerated(0.07) | possibly_damaging(0.498) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFP90 | SNV | Missense_Mutation | rs759207558 | c.1240A>G | p.Arg414Gly | p.R414G | Q8TF47 | protein_coding | deleterious(0) | benign(0.421) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |