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Gene: ZER1 |
Gene summary for ZER1 |
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Gene information | Species | Human | Gene symbol | ZER1 | Gene ID | 10444 |
Gene name | zyg-11 related cell cycle regulator | |
Gene Alias | C9orf60 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024R8B0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10444 | ZER1 | CCI_2 | Human | Cervix | CC | 2.39e-09 | 7.69e-01 | 0.5249 |
10444 | ZER1 | CCI_3 | Human | Cervix | CC | 1.13e-07 | 5.45e-01 | 0.516 |
10444 | ZER1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-10 | 4.97e-01 | -0.1954 |
10444 | ZER1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.83e-02 | 9.48e-01 | -0.2602 |
10444 | ZER1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.50e-11 | 5.37e-01 | -0.1464 |
10444 | ZER1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.29e-02 | 3.11e-01 | -0.0842 |
10444 | ZER1 | A015-C-203 | Human | Colorectum | FAP | 2.96e-05 | -4.51e-02 | -0.1294 |
10444 | ZER1 | A002-C-205 | Human | Colorectum | FAP | 2.89e-04 | -9.88e-02 | -0.1236 |
10444 | ZER1 | A015-C-006 | Human | Colorectum | FAP | 2.47e-02 | 1.48e-02 | -0.0994 |
10444 | ZER1 | A002-C-114 | Human | Colorectum | FAP | 8.08e-03 | -1.14e-01 | -0.1561 |
10444 | ZER1 | A015-C-104 | Human | Colorectum | FAP | 6.12e-06 | -1.08e-01 | -0.1899 |
10444 | ZER1 | A001-C-014 | Human | Colorectum | FAP | 2.83e-02 | -9.96e-02 | 0.0135 |
10444 | ZER1 | A002-C-016 | Human | Colorectum | FAP | 5.62e-04 | -1.64e-01 | 0.0521 |
10444 | ZER1 | A002-C-116 | Human | Colorectum | FAP | 4.75e-08 | -1.43e-01 | -0.0452 |
10444 | ZER1 | A014-C-008 | Human | Colorectum | FAP | 2.78e-02 | -1.91e-01 | -0.191 |
10444 | ZER1 | A018-E-020 | Human | Colorectum | FAP | 1.23e-04 | -2.20e-01 | -0.2034 |
10444 | ZER1 | F034 | Human | Colorectum | FAP | 4.93e-04 | -1.20e-01 | -0.0665 |
10444 | ZER1 | HTA12-25-1 | Human | Pancreas | PDAC | 2.54e-04 | 5.91e-01 | 0.313 |
10444 | ZER1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.39e-07 | 5.71e-01 | 0.3728 |
10444 | ZER1 | HTA12-29-1 | Human | Pancreas | PDAC | 2.46e-20 | 5.90e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:19030528 | Cervix | CC | positive regulation of proteolysis involved in cellular protein catabolic process | 34/2311 | 133/18723 | 2.28e-05 | 4.01e-04 | 34 |
GO:200006010 | Cervix | CC | positive regulation of ubiquitin-dependent protein catabolic process | 29/2311 | 107/18723 | 2.77e-05 | 4.62e-04 | 29 |
GO:00324369 | Cervix | CC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 25/2311 | 90/18723 | 6.22e-05 | 8.90e-04 | 25 |
GO:19018008 | Cervix | CC | positive regulation of proteasomal protein catabolic process | 29/2311 | 114/18723 | 9.71e-05 | 1.27e-03 | 29 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZER1 | SNV | Missense_Mutation | c.1358N>T | p.Thr453Met | p.T453M | Q7Z7L7 | protein_coding | deleterious(0) | possibly_damaging(0.677) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZER1 | SNV | Missense_Mutation | rs780231279 | c.1909G>A | p.Val637Ile | p.V637I | Q7Z7L7 | protein_coding | tolerated(0.22) | probably_damaging(0.984) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | novel | c.1175N>A | p.Arg392Gln | p.R392Q | Q7Z7L7 | protein_coding | tolerated(0.38) | possibly_damaging(0.733) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | rs781260934 | c.202N>A | p.Glu68Lys | p.E68K | Q7Z7L7 | protein_coding | tolerated(0.12) | benign(0.058) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZER1 | SNV | Missense_Mutation | c.1984N>T | p.Arg662Cys | p.R662C | Q7Z7L7 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ZER1 | SNV | Missense_Mutation | novel | c.1886N>G | p.Glu629Gly | p.E629G | Q7Z7L7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | c.643N>T | p.Ala215Ser | p.A215S | Q7Z7L7 | protein_coding | tolerated(0.48) | benign(0.006) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZER1 | SNV | Missense_Mutation | c.911C>T | p.Ala304Val | p.A304V | Q7Z7L7 | protein_coding | tolerated(0.58) | benign(0.005) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZER1 | SNV | Missense_Mutation | rs776299057 | c.2291N>T | p.Thr764Met | p.T764M | Q7Z7L7 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZER1 | SNV | Missense_Mutation | novel | c.764N>A | p.Arg255Gln | p.R255Q | Q7Z7L7 | protein_coding | tolerated(0.81) | benign(0.005) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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