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Gene: ZDHHC14 |
Gene summary for ZDHHC14 |
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Gene information | Species | Human | Gene symbol | ZDHHC14 | Gene ID | 79683 |
Gene name | zinc finger DHHC-type palmitoyltransferase 14 | |
Gene Alias | NEW1CP | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8IZN3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79683 | ZDHHC14 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.91e-03 | 4.73e-01 | -0.0811 |
79683 | ZDHHC14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.40e-10 | 6.10e-01 | -0.1954 |
79683 | ZDHHC14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.48e-07 | 8.21e-01 | -0.059 |
79683 | ZDHHC14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.42e-04 | -2.62e-01 | 0.294 |
79683 | ZDHHC14 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.63e-03 | 4.59e-01 | 0.281 |
79683 | ZDHHC14 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.59e-07 | -3.32e-01 | 0.3005 |
79683 | ZDHHC14 | A015-C-203 | Human | Colorectum | FAP | 4.82e-19 | -3.88e-01 | -0.1294 |
79683 | ZDHHC14 | A014-C-040 | Human | Colorectum | FAP | 3.58e-02 | -4.75e-01 | -0.1184 |
79683 | ZDHHC14 | A002-C-201 | Human | Colorectum | FAP | 4.06e-04 | -2.21e-01 | 0.0324 |
79683 | ZDHHC14 | A001-C-119 | Human | Colorectum | FAP | 9.96e-03 | -3.51e-01 | -0.1557 |
79683 | ZDHHC14 | A001-C-108 | Human | Colorectum | FAP | 3.88e-14 | -3.88e-01 | -0.0272 |
79683 | ZDHHC14 | A002-C-205 | Human | Colorectum | FAP | 2.80e-09 | -3.07e-01 | -0.1236 |
79683 | ZDHHC14 | A001-C-104 | Human | Colorectum | FAP | 1.51e-04 | -2.89e-01 | 0.0184 |
79683 | ZDHHC14 | A015-C-006 | Human | Colorectum | FAP | 1.49e-04 | -2.75e-01 | -0.0994 |
79683 | ZDHHC14 | A015-C-106 | Human | Colorectum | FAP | 4.33e-09 | -3.26e-01 | -0.0511 |
79683 | ZDHHC14 | A002-C-114 | Human | Colorectum | FAP | 1.35e-07 | -3.22e-01 | -0.1561 |
79683 | ZDHHC14 | A015-C-104 | Human | Colorectum | FAP | 1.04e-18 | -4.02e-01 | -0.1899 |
79683 | ZDHHC14 | A001-C-014 | Human | Colorectum | FAP | 7.20e-09 | -3.38e-01 | 0.0135 |
79683 | ZDHHC14 | A002-C-016 | Human | Colorectum | FAP | 9.19e-14 | -3.03e-01 | 0.0521 |
79683 | ZDHHC14 | A015-C-002 | Human | Colorectum | FAP | 1.10e-06 | -4.46e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:0006612 | Colorectum | FAP | protein targeting to membrane | 30/2622 | 131/18723 | 3.95e-03 | 2.75e-02 | 30 |
GO:00901505 | Colorectum | CRC | establishment of protein localization to membrane | 51/2078 | 260/18723 | 3.59e-05 | 9.05e-04 | 51 |
GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDHHC14 | deletion | Frame_Shift_Del | c.625delN | p.Tyr211IlefsTer10 | p.Y211Ifs*10 | Q8IZN3 | protein_coding | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |||
ZDHHC14 | deletion | Frame_Shift_Del | c.625delN | p.Tyr211IlefsTer10 | p.Y211Ifs*10 | Q8IZN3 | protein_coding | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |||
ZDHHC14 | SNV | Missense_Mutation | novel | c.410N>A | p.Ile137Asn | p.I137N | Q8IZN3 | protein_coding | tolerated(0.34) | benign(0.366) | TCGA-WQ-A9G7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZDHHC14 | SNV | Missense_Mutation | c.430G>T | p.Gly144Trp | p.G144W | Q8IZN3 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-05-4250-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZDHHC14 | SNV | Missense_Mutation | c.361N>T | p.Pro121Ser | p.P121S | Q8IZN3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
ZDHHC14 | SNV | Missense_Mutation | c.440G>C | p.Arg147Pro | p.R147P | Q8IZN3 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
ZDHHC14 | SNV | Missense_Mutation | novel | c.532G>C | p.Ala178Pro | p.A178P | Q8IZN3 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-86-7954-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZDHHC14 | SNV | Missense_Mutation | c.473A>G | p.Asn158Ser | p.N158S | Q8IZN3 | protein_coding | deleterious(0.03) | possibly_damaging(0.74) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZDHHC14 | SNV | Missense_Mutation | c.1310A>T | p.Gln437Leu | p.Q437L | Q8IZN3 | protein_coding | deleterious_low_confidence(0.02) | benign(0.104) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZDHHC14 | SNV | Missense_Mutation | novel | c.1042N>T | p.Gly348Trp | p.G348W | Q8IZN3 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-46-3766-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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