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Gene: ZC3H7A |
Gene summary for ZC3H7A |
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Gene information | Species | Human | Gene symbol | ZC3H7A | Gene ID | 29066 |
Gene name | zinc finger CCCH-type containing 7A | |
Gene Alias | HSPC055 | |
Cytomap | 16p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IWR0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29066 | ZC3H7A | LZE4T | Human | Esophagus | ESCC | 1.16e-08 | 1.74e-01 | 0.0811 |
29066 | ZC3H7A | LZE7T | Human | Esophagus | ESCC | 3.50e-08 | 2.73e-01 | 0.0667 |
29066 | ZC3H7A | LZE20T | Human | Esophagus | ESCC | 7.11e-07 | 1.83e-01 | 0.0662 |
29066 | ZC3H7A | LZE24T | Human | Esophagus | ESCC | 1.62e-08 | 1.61e-01 | 0.0596 |
29066 | ZC3H7A | LZE21T | Human | Esophagus | ESCC | 5.72e-03 | 2.22e-01 | 0.0655 |
29066 | ZC3H7A | LZE6T | Human | Esophagus | ESCC | 2.81e-02 | 7.77e-02 | 0.0845 |
29066 | ZC3H7A | P1T-E | Human | Esophagus | ESCC | 7.08e-06 | 5.36e-01 | 0.0875 |
29066 | ZC3H7A | P2T-E | Human | Esophagus | ESCC | 6.01e-51 | 8.33e-01 | 0.1177 |
29066 | ZC3H7A | P4T-E | Human | Esophagus | ESCC | 2.86e-13 | 2.62e-01 | 0.1323 |
29066 | ZC3H7A | P5T-E | Human | Esophagus | ESCC | 3.25e-11 | 1.80e-01 | 0.1327 |
29066 | ZC3H7A | P8T-E | Human | Esophagus | ESCC | 8.61e-27 | 4.87e-01 | 0.0889 |
29066 | ZC3H7A | P9T-E | Human | Esophagus | ESCC | 1.96e-06 | 1.18e-01 | 0.1131 |
29066 | ZC3H7A | P10T-E | Human | Esophagus | ESCC | 2.57e-16 | 2.54e-01 | 0.116 |
29066 | ZC3H7A | P11T-E | Human | Esophagus | ESCC | 9.56e-09 | 4.37e-01 | 0.1426 |
29066 | ZC3H7A | P12T-E | Human | Esophagus | ESCC | 1.69e-29 | 4.72e-01 | 0.1122 |
29066 | ZC3H7A | P15T-E | Human | Esophagus | ESCC | 1.29e-22 | 4.75e-01 | 0.1149 |
29066 | ZC3H7A | P16T-E | Human | Esophagus | ESCC | 1.94e-25 | 5.30e-01 | 0.1153 |
29066 | ZC3H7A | P17T-E | Human | Esophagus | ESCC | 4.52e-05 | 3.51e-01 | 0.1278 |
29066 | ZC3H7A | P20T-E | Human | Esophagus | ESCC | 6.51e-35 | 7.51e-01 | 0.1124 |
29066 | ZC3H7A | P21T-E | Human | Esophagus | ESCC | 2.02e-13 | 2.37e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00351969 | Esophagus | ESCC | production of miRNAs involved in gene silencing by miRNA | 37/8552 | 52/18723 | 1.75e-04 | 1.14e-03 | 37 |
GO:00310508 | Esophagus | ESCC | dsRNA processing | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:00709188 | Esophagus | ESCC | production of small RNA involved in gene silencing by RNA | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:003105021 | Liver | HCC | dsRNA processing | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:007091821 | Liver | HCC | production of small RNA involved in gene silencing by RNA | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:003519621 | Liver | HCC | production of miRNAs involved in gene silencing by miRNA | 36/7958 | 52/18723 | 8.79e-05 | 7.66e-04 | 36 |
GO:00310507 | Oral cavity | OSCC | dsRNA processing | 31/7305 | 54/18723 | 4.66e-03 | 1.87e-02 | 31 |
GO:00709187 | Oral cavity | OSCC | production of small RNA involved in gene silencing by RNA | 31/7305 | 54/18723 | 4.66e-03 | 1.87e-02 | 31 |
GO:00351968 | Oral cavity | OSCC | production of miRNAs involved in gene silencing by miRNA | 30/7305 | 52/18723 | 4.84e-03 | 1.92e-02 | 30 |
GO:003519622 | Oral cavity | EOLP | production of miRNAs involved in gene silencing by miRNA | 16/2218 | 52/18723 | 2.25e-04 | 2.22e-03 | 16 |
GO:003105022 | Oral cavity | EOLP | dsRNA processing | 16/2218 | 54/18723 | 3.63e-04 | 3.32e-03 | 16 |
GO:007091822 | Oral cavity | EOLP | production of small RNA involved in gene silencing by RNA | 16/2218 | 54/18723 | 3.63e-04 | 3.32e-03 | 16 |
GO:003519616 | Thyroid | PTC | production of miRNAs involved in gene silencing by miRNA | 28/5968 | 52/18723 | 8.33e-04 | 5.13e-03 | 28 |
GO:003105010 | Thyroid | PTC | dsRNA processing | 28/5968 | 54/18723 | 1.79e-03 | 9.68e-03 | 28 |
GO:007091810 | Thyroid | PTC | production of small RNA involved in gene silencing by RNA | 28/5968 | 54/18723 | 1.79e-03 | 9.68e-03 | 28 |
GO:003519617 | Thyroid | ATC | production of miRNAs involved in gene silencing by miRNA | 29/6293 | 52/18723 | 8.30e-04 | 4.57e-03 | 29 |
GO:003105016 | Thyroid | ATC | dsRNA processing | 29/6293 | 54/18723 | 1.84e-03 | 9.03e-03 | 29 |
GO:007091816 | Thyroid | ATC | production of small RNA involved in gene silencing by RNA | 29/6293 | 54/18723 | 1.84e-03 | 9.03e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H7A | SNV | Missense_Mutation | c.2138C>T | p.Ala713Val | p.A713V | Q8IWR0 | protein_coding | deleterious(0) | possibly_damaging(0.597) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZC3H7A | SNV | Missense_Mutation | c.1097A>C | p.Glu366Ala | p.E366A | Q8IWR0 | protein_coding | tolerated(0.34) | benign(0.141) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZC3H7A | SNV | Missense_Mutation | c.2057N>T | p.Glu686Val | p.E686V | Q8IWR0 | protein_coding | deleterious(0.02) | possibly_damaging(0.548) | TCGA-CK-4948-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZC3H7A | SNV | Missense_Mutation | c.994N>C | p.Gly332Arg | p.G332R | Q8IWR0 | protein_coding | tolerated(0.19) | benign(0.015) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
ZC3H7A | SNV | Missense_Mutation | c.185N>T | p.Ser62Leu | p.S62L | Q8IWR0 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZC3H7A | SNV | Missense_Mutation | novel | c.131N>T | p.Arg44Ile | p.R44I | Q8IWR0 | protein_coding | tolerated(0.07) | benign(0.142) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZC3H7A | SNV | Missense_Mutation | novel | c.2150N>T | p.Arg717Ile | p.R717I | Q8IWR0 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZC3H7A | SNV | Missense_Mutation | c.1206N>T | p.Glu402Asp | p.E402D | Q8IWR0 | protein_coding | tolerated(0.5) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ZC3H7A | SNV | Missense_Mutation | novel | c.2566N>A | p.Asp856Asn | p.D856N | Q8IWR0 | protein_coding | deleterious(0.02) | possibly_damaging(0.87) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZC3H7A | SNV | Missense_Mutation | c.2079N>T | p.Gln693His | p.Q693H | Q8IWR0 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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