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Gene: ZBTB38 |
Gene summary for ZBTB38 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB38 | Gene ID | 253461 |
Gene name | zinc finger and BTB domain containing 38 | |
Gene Alias | CIBZ | |
Cytomap | 3q23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NAP3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253461 | ZBTB38 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.28e-04 | -3.68e-01 | 0.0155 |
253461 | ZBTB38 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.88e-07 | -4.71e-01 | -0.1808 |
253461 | ZBTB38 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.28e-11 | -7.45e-01 | -0.1207 |
253461 | ZBTB38 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.17e-04 | -5.40e-01 | -0.2061 |
253461 | ZBTB38 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.79e-04 | -8.45e-01 | -0.1462 |
253461 | ZBTB38 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.23e-02 | -3.65e-01 | 0.096 |
253461 | ZBTB38 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.94e-04 | -6.32e-01 | 0.0528 |
253461 | ZBTB38 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.93e-02 | -3.10e-01 | 0.0338 |
253461 | ZBTB38 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.07e-26 | -6.83e-01 | 0.294 |
253461 | ZBTB38 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.81e-05 | -4.24e-01 | 0.2585 |
253461 | ZBTB38 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.53e-37 | -8.73e-01 | 0.3005 |
253461 | ZBTB38 | A015-C-203 | Human | Colorectum | FAP | 4.20e-32 | -1.76e-01 | -0.1294 |
253461 | ZBTB38 | A015-C-204 | Human | Colorectum | FAP | 1.53e-04 | -1.22e-01 | -0.0228 |
253461 | ZBTB38 | A014-C-040 | Human | Colorectum | FAP | 2.99e-03 | -3.05e-02 | -0.1184 |
253461 | ZBTB38 | A002-C-201 | Human | Colorectum | FAP | 3.49e-09 | 3.51e-02 | 0.0324 |
253461 | ZBTB38 | A001-C-119 | Human | Colorectum | FAP | 2.29e-08 | -4.60e-01 | -0.1557 |
253461 | ZBTB38 | A001-C-108 | Human | Colorectum | FAP | 1.45e-15 | -1.53e-01 | -0.0272 |
253461 | ZBTB38 | A002-C-205 | Human | Colorectum | FAP | 2.33e-22 | -1.47e-01 | -0.1236 |
253461 | ZBTB38 | A015-C-005 | Human | Colorectum | FAP | 3.20e-02 | 1.71e-01 | -0.0336 |
253461 | ZBTB38 | A015-C-006 | Human | Colorectum | FAP | 1.43e-17 | -4.79e-01 | -0.0994 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006275 | Colorectum | CRC | regulation of DNA replication | 21/2078 | 107/18723 | 6.56e-03 | 4.70e-02 | 21 |
GO:00062752 | Endometrium | AEH | regulation of DNA replication | 21/2100 | 107/18723 | 7.38e-03 | 4.20e-02 | 21 |
GO:000627511 | Endometrium | EEC | regulation of DNA replication | 22/2168 | 107/18723 | 5.09e-03 | 3.20e-02 | 22 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:00062753 | Oral cavity | OSCC | regulation of DNA replication | 62/7305 | 107/18723 | 5.49e-05 | 4.54e-04 | 62 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
GO:00062756 | Thyroid | ATC | regulation of DNA replication | 50/6293 | 107/18723 | 3.25e-03 | 1.46e-02 | 50 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB38 | SNV | Missense_Mutation | c.2660G>A | p.Ser887Asn | p.S887N | Q8NAP3 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB38 | SNV | Missense_Mutation | c.2606N>G | p.Gln869Arg | p.Q869R | Q8NAP3 | protein_coding | tolerated(0.43) | benign(0.024) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZBTB38 | SNV | Missense_Mutation | rs368195627 | c.1532N>T | p.Thr511Met | p.T511M | Q8NAP3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZBTB38 | SNV | Missense_Mutation | novel | c.1765N>A | p.Ala589Thr | p.A589T | Q8NAP3 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB38 | SNV | Missense_Mutation | c.2027C>A | p.Ser676Tyr | p.S676Y | Q8NAP3 | protein_coding | deleterious(0.01) | possibly_damaging(0.635) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZBTB38 | SNV | Missense_Mutation | c.2969N>G | p.Asp990Gly | p.D990G | Q8NAP3 | protein_coding | deleterious(0.04) | benign(0.02) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB38 | SNV | Missense_Mutation | novel | c.1930N>G | p.Ser644Ala | p.S644A | Q8NAP3 | protein_coding | tolerated(0.76) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB38 | SNV | Missense_Mutation | c.1012C>T | p.Pro338Ser | p.P338S | Q8NAP3 | protein_coding | tolerated(0.24) | benign(0.024) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB38 | SNV | Missense_Mutation | c.3023N>A | p.Arg1008Gln | p.R1008Q | Q8NAP3 | protein_coding | tolerated(0.12) | benign(0.057) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB38 | SNV | Missense_Mutation | rs200031071 | c.3037G>A | p.Glu1013Lys | p.E1013K | Q8NAP3 | protein_coding | deleterious(0.04) | possibly_damaging(0.73) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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