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Gene: YPEL1 |
Gene summary for YPEL1 |
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Gene information | Species | Human | Gene symbol | YPEL1 | Gene ID | 29799 |
Gene name | yippee like 1 | |
Gene Alias | FKSG3 | |
Cytomap | 22q11.21-q11.22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O60688 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29799 | YPEL1 | HCC1_Meng | Human | Liver | HCC | 1.04e-02 | -2.31e-02 | 0.0246 |
29799 | YPEL1 | HCC1 | Human | Liver | HCC | 9.45e-09 | 2.92e+00 | 0.5336 |
29799 | YPEL1 | HCC2 | Human | Liver | HCC | 3.66e-25 | 2.32e+00 | 0.5341 |
29799 | YPEL1 | HCC5 | Human | Liver | HCC | 3.53e-16 | 2.61e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YPEL1 | SNV | Missense_Mutation | rs748295997 | c.92C>T | p.Ala31Val | p.A31V | O60688 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
YPEL1 | SNV | Missense_Mutation | rs779788033 | c.254N>T | p.Thr85Met | p.T85M | O60688 | protein_coding | tolerated(0.07) | possibly_damaging(0.714) | TCGA-BR-8686-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
YPEL1 | SNV | Missense_Mutation | c.355N>A | p.Glu119Lys | p.E119K | O60688 | protein_coding | deleterious_low_confidence(0) | benign(0.046) | TCGA-DJ-A2QC-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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