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Gene: YAF2 |
Gene summary for YAF2 |
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Gene information | Species | Human | Gene symbol | YAF2 | Gene ID | 10138 |
Gene name | YY1 associated factor 2 | |
Gene Alias | YAF2 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IY57 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10138 | YAF2 | LZE2T | Human | Esophagus | ESCC | 5.27e-03 | 2.48e-01 | 0.082 |
10138 | YAF2 | LZE4T | Human | Esophagus | ESCC | 1.30e-10 | 1.95e-01 | 0.0811 |
10138 | YAF2 | LZE8T | Human | Esophagus | ESCC | 4.54e-02 | 1.10e-02 | 0.067 |
10138 | YAF2 | LZE20T | Human | Esophagus | ESCC | 1.97e-02 | -1.41e-02 | 0.0662 |
10138 | YAF2 | LZE24T | Human | Esophagus | ESCC | 1.96e-12 | 2.06e-01 | 0.0596 |
10138 | YAF2 | LZE21T | Human | Esophagus | ESCC | 1.29e-03 | 8.65e-02 | 0.0655 |
10138 | YAF2 | LZE6T | Human | Esophagus | ESCC | 2.47e-02 | 3.67e-02 | 0.0845 |
10138 | YAF2 | P1T-E | Human | Esophagus | ESCC | 4.50e-04 | 2.48e-01 | 0.0875 |
10138 | YAF2 | P2T-E | Human | Esophagus | ESCC | 9.38e-25 | 5.11e-01 | 0.1177 |
10138 | YAF2 | P4T-E | Human | Esophagus | ESCC | 1.08e-10 | 3.19e-01 | 0.1323 |
10138 | YAF2 | P5T-E | Human | Esophagus | ESCC | 1.27e-10 | 6.98e-02 | 0.1327 |
10138 | YAF2 | P8T-E | Human | Esophagus | ESCC | 2.48e-29 | 5.81e-01 | 0.0889 |
10138 | YAF2 | P9T-E | Human | Esophagus | ESCC | 8.33e-10 | 9.82e-02 | 0.1131 |
10138 | YAF2 | P10T-E | Human | Esophagus | ESCC | 1.32e-15 | 3.17e-01 | 0.116 |
10138 | YAF2 | P11T-E | Human | Esophagus | ESCC | 6.43e-05 | 1.68e-01 | 0.1426 |
10138 | YAF2 | P12T-E | Human | Esophagus | ESCC | 2.42e-09 | 2.98e-01 | 0.1122 |
10138 | YAF2 | P15T-E | Human | Esophagus | ESCC | 6.05e-07 | 1.69e-01 | 0.1149 |
10138 | YAF2 | P16T-E | Human | Esophagus | ESCC | 4.97e-17 | 2.38e-01 | 0.1153 |
10138 | YAF2 | P19T-E | Human | Esophagus | ESCC | 6.96e-03 | 2.38e-01 | 0.1662 |
10138 | YAF2 | P20T-E | Human | Esophagus | ESCC | 1.66e-09 | 3.46e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YAF2 | deletion | Frame_Shift_Del | novel | c.228delN | p.Lys76AsnfsTer31 | p.K76Nfs*31 | Q8IY57 | protein_coding | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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