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Gene: XPO6 |
Gene summary for XPO6 |
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Gene information | Species | Human | Gene symbol | XPO6 | Gene ID | 23214 |
Gene name | exportin 6 | |
Gene Alias | EXP6 | |
Cytomap | 16p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006611 | UniProtAcc | Q96QU8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23214 | XPO6 | LZE7T | Human | Esophagus | ESCC | 9.72e-07 | 4.26e-01 | 0.0667 |
23214 | XPO6 | LZE24T | Human | Esophagus | ESCC | 4.36e-05 | 3.23e-01 | 0.0596 |
23214 | XPO6 | P1T-E | Human | Esophagus | ESCC | 5.20e-05 | 2.85e-01 | 0.0875 |
23214 | XPO6 | P2T-E | Human | Esophagus | ESCC | 2.66e-05 | 1.29e-01 | 0.1177 |
23214 | XPO6 | P4T-E | Human | Esophagus | ESCC | 2.01e-18 | 5.15e-01 | 0.1323 |
23214 | XPO6 | P5T-E | Human | Esophagus | ESCC | 1.66e-22 | 2.20e-01 | 0.1327 |
23214 | XPO6 | P8T-E | Human | Esophagus | ESCC | 5.73e-19 | 2.85e-01 | 0.0889 |
23214 | XPO6 | P9T-E | Human | Esophagus | ESCC | 1.48e-04 | 8.26e-02 | 0.1131 |
23214 | XPO6 | P10T-E | Human | Esophagus | ESCC | 7.07e-13 | 7.16e-02 | 0.116 |
23214 | XPO6 | P12T-E | Human | Esophagus | ESCC | 5.42e-12 | 2.15e-01 | 0.1122 |
23214 | XPO6 | P15T-E | Human | Esophagus | ESCC | 9.48e-07 | 1.12e-01 | 0.1149 |
23214 | XPO6 | P16T-E | Human | Esophagus | ESCC | 9.61e-10 | 1.12e-01 | 0.1153 |
23214 | XPO6 | P17T-E | Human | Esophagus | ESCC | 8.64e-04 | 2.79e-01 | 0.1278 |
23214 | XPO6 | P20T-E | Human | Esophagus | ESCC | 1.74e-03 | 1.10e-01 | 0.1124 |
23214 | XPO6 | P21T-E | Human | Esophagus | ESCC | 7.49e-17 | 2.72e-01 | 0.1617 |
23214 | XPO6 | P22T-E | Human | Esophagus | ESCC | 2.44e-05 | 1.02e-01 | 0.1236 |
23214 | XPO6 | P23T-E | Human | Esophagus | ESCC | 5.50e-03 | 1.20e-01 | 0.108 |
23214 | XPO6 | P24T-E | Human | Esophagus | ESCC | 2.19e-06 | 1.40e-01 | 0.1287 |
23214 | XPO6 | P26T-E | Human | Esophagus | ESCC | 4.90e-15 | 8.66e-02 | 0.1276 |
23214 | XPO6 | P27T-E | Human | Esophagus | ESCC | 9.50e-11 | 6.24e-02 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:000661117 | Esophagus | ESCC | protein export from nucleus | 48/8552 | 57/18723 | 1.92e-09 | 4.39e-08 | 48 |
GO:000691312 | Liver | Cirrhotic | nucleocytoplasmic transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116912 | Liver | Cirrhotic | nuclear transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116812 | Liver | Cirrhotic | nuclear export | 67/4634 | 154/18723 | 2.57e-07 | 6.41e-06 | 67 |
GO:00066114 | Liver | Cirrhotic | protein export from nucleus | 27/4634 | 57/18723 | 1.74e-04 | 1.63e-03 | 27 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116822 | Liver | HCC | nuclear export | 113/7958 | 154/18723 | 6.30e-15 | 4.39e-13 | 113 |
GO:000661112 | Liver | HCC | protein export from nucleus | 42/7958 | 57/18723 | 1.75e-06 | 2.45e-05 | 42 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:00066119 | Oral cavity | OSCC | protein export from nucleus | 42/7305 | 57/18723 | 1.10e-07 | 1.87e-06 | 42 |
GO:000691323 | Oral cavity | EOLP | nucleocytoplasmic transport | 87/2218 | 301/18723 | 7.30e-16 | 4.37e-13 | 87 |
GO:005116923 | Oral cavity | EOLP | nuclear transport | 87/2218 | 301/18723 | 7.30e-16 | 4.37e-13 | 87 |
GO:005116824 | Oral cavity | EOLP | nuclear export | 47/2218 | 154/18723 | 4.45e-10 | 3.76e-08 | 47 |
GO:000661123 | Oral cavity | EOLP | protein export from nucleus | 19/2218 | 57/18723 | 1.70e-05 | 2.79e-04 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XPO6 | SNV | Missense_Mutation | c.437G>T | p.Gly146Val | p.G146V | Q96QU8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
XPO6 | SNV | Missense_Mutation | c.3085N>A | p.Val1029Met | p.V1029M | Q96QU8 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
XPO6 | SNV | Missense_Mutation | novel | c.302N>T | p.Thr101Ile | p.T101I | Q96QU8 | protein_coding | tolerated(0.2) | benign(0.01) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
XPO6 | SNV | Missense_Mutation | c.112N>G | p.Phe38Val | p.F38V | Q96QU8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
XPO6 | SNV | Missense_Mutation | rs145368246 | c.2288N>A | p.Arg763His | p.R763H | Q96QU8 | protein_coding | tolerated(0.12) | benign(0.054) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
XPO6 | SNV | Missense_Mutation | rs377255371 | c.382G>A | p.Asp128Asn | p.D128N | Q96QU8 | protein_coding | tolerated(0.05) | benign(0.271) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
XPO6 | SNV | Missense_Mutation | c.1090N>A | p.Asp364Asn | p.D364N | Q96QU8 | protein_coding | tolerated(0.11) | probably_damaging(0.967) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
XPO6 | SNV | Missense_Mutation | novel | c.1300N>C | p.Ser434Arg | p.S434R | Q96QU8 | protein_coding | tolerated(0.06) | benign(0.054) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
XPO6 | SNV | Missense_Mutation | novel | c.658A>G | p.Asn220Asp | p.N220D | Q96QU8 | protein_coding | tolerated(0.26) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
XPO6 | SNV | Missense_Mutation | rs748737569 | c.1736G>A | p.Arg579Gln | p.R579Q | Q96QU8 | protein_coding | tolerated(0.08) | possibly_damaging(0.886) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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