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Gene: WWTR1 |
Gene summary for WWTR1 |
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Gene information | Species | Human | Gene symbol | WWTR1 | Gene ID | 25937 |
Gene name | WW domain containing transcription regulator 1 | |
Gene Alias | TAZ | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25937 | WWTR1 | CA_HPV_3 | Human | Cervix | CC | 2.68e-03 | 1.21e-01 | 0.0414 |
25937 | WWTR1 | CCI_1 | Human | Cervix | CC | 2.45e-02 | 7.22e-01 | 0.528 |
25937 | WWTR1 | CCI_2 | Human | Cervix | CC | 2.19e-16 | 1.85e+00 | 0.5249 |
25937 | WWTR1 | CCI_3 | Human | Cervix | CC | 1.52e-13 | 9.59e-01 | 0.516 |
25937 | WWTR1 | T1 | Human | Cervix | CC | 3.93e-10 | 4.51e-01 | 0.0918 |
25937 | WWTR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.21e-05 | 2.92e-01 | -0.0811 |
25937 | WWTR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.23e-10 | 3.10e-01 | -0.1954 |
25937 | WWTR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.27e-02 | 5.72e-01 | -0.2602 |
25937 | WWTR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.49e-08 | 3.78e-01 | -0.059 |
25937 | WWTR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.25e-02 | 2.64e-01 | -0.0179 |
25937 | WWTR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.18e-05 | 3.62e-01 | 0.096 |
25937 | WWTR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.50e-21 | 5.46e-01 | 0.294 |
25937 | WWTR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.49e-08 | 9.05e-01 | 0.3487 |
25937 | WWTR1 | A001-C-119 | Human | Colorectum | FAP | 6.01e-04 | 4.34e-01 | -0.1557 |
25937 | WWTR1 | AEH-subject1 | Human | Endometrium | AEH | 1.24e-07 | 3.40e-01 | -0.3059 |
25937 | WWTR1 | AEH-subject2 | Human | Endometrium | AEH | 5.66e-08 | 2.41e-01 | -0.2525 |
25937 | WWTR1 | AEH-subject3 | Human | Endometrium | AEH | 1.33e-07 | 9.98e-02 | -0.2576 |
25937 | WWTR1 | AEH-subject4 | Human | Endometrium | AEH | 2.00e-08 | 3.56e-01 | -0.2657 |
25937 | WWTR1 | AEH-subject5 | Human | Endometrium | AEH | 1.96e-33 | 8.33e-01 | -0.2953 |
25937 | WWTR1 | EEC-subject1 | Human | Endometrium | EEC | 2.73e-26 | 6.79e-01 | -0.2682 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa043907 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439012 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439022 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439032 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439041 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439051 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WWTR1 | SNV | Missense_Mutation | c.529N>T | p.Val177Leu | p.V177L | Q9GZV5 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-55-8510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WWTR1 | SNV | Missense_Mutation | c.605N>T | p.Ser202Ile | p.S202I | Q9GZV5 | protein_coding | tolerated(0.09) | benign(0.037) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WWTR1 | SNV | Missense_Mutation | c.272C>T | p.Pro91Leu | p.P91L | Q9GZV5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-33-4589-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WWTR1 | SNV | Missense_Mutation | novel | c.547N>T | p.Ala183Ser | p.A183S | Q9GZV5 | protein_coding | tolerated(0.26) | benign(0.066) | TCGA-85-8352-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
WWTR1 | SNV | Missense_Mutation | novel | c.419N>T | p.Arg140Met | p.R140M | Q9GZV5 | protein_coding | deleterious(0.02) | possibly_damaging(0.608) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WWTR1 | SNV | Missense_Mutation | rs377048586 | c.514N>A | p.Val172Ile | p.V172I | Q9GZV5 | protein_coding | tolerated(0.28) | benign(0) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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