GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:200057319 | Esophagus | ESCC | positive regulation of DNA biosynthetic process | 56/8552 | 66/18723 | 4.51e-11 | 1.45e-09 | 56 |
GO:2000278110 | Esophagus | ESCC | regulation of DNA biosynthetic process | 81/8552 | 106/18723 | 9.81e-11 | 2.96e-09 | 81 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:000700418 | Esophagus | ESCC | telomere maintenance via telomerase | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003450211 | Esophagus | ESCC | protein localization to chromosome | 70/8552 | 92/18723 | 2.54e-09 | 5.64e-08 | 70 |
GO:001083319 | Esophagus | ESCC | telomere maintenance via telomere lengthening | 61/8552 | 81/18723 | 5.24e-08 | 9.37e-07 | 61 |
GO:005197217 | Esophagus | ESCC | regulation of telomerase activity | 39/8552 | 47/18723 | 1.48e-07 | 2.35e-06 | 39 |
GO:005197318 | Esophagus | ESCC | positive regulation of telomerase activity | 30/8552 | 34/18723 | 2.73e-07 | 4.02e-06 | 30 |
GO:000627816 | Esophagus | ESCC | RNA-dependent DNA biosynthetic process | 56/8552 | 75/18723 | 3.03e-07 | 4.30e-06 | 56 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WRAP53 | SNV | Missense_Mutation | novel | c.238G>A | p.Glu80Lys | p.E80K | Q9BUR4 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
WRAP53 | SNV | Missense_Mutation | novel | c.581G>A | p.Arg194Gln | p.R194Q | Q9BUR4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
WRAP53 | SNV | Missense_Mutation | novel | c.581G>A | p.Arg194Gln | p.R194Q | Q9BUR4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WRAP53 | insertion | In_Frame_Ins | novel | c.429_430insGCTTTC | p.Asp143_Thr144insAlaPhe | p.D143_T144insAF | Q9BUR4 | protein_coding | | | TCGA-AP-A05H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
WRAP53 | insertion | In_Frame_Ins | novel | c.430_431insAAAGAATTGGCGTCCGCTGTTCGCCTCTCCTCC | p.Thr144delinsLysArgIleGlyValArgCysSerProLeuLeuPro | p.T144delinsKRIGVRCSPLLP | Q9BUR4 | protein_coding | | | TCGA-AP-A05H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
WRAP53 | deletion | Frame_Shift_Del | novel | c.1106delG | p.Gly369AlafsTer43 | p.G369Afs*43 | Q9BUR4 | protein_coding | | | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
WRAP53 | deletion | Frame_Shift_Del | novel | c.905delN | p.Ser304ProfsTer28 | p.S304Pfs*28 | Q9BUR4 | protein_coding | | | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WRAP53 | SNV | Missense_Mutation | novel | c.1475N>T | p.Gly492Val | p.G492V | Q9BUR4 | protein_coding | tolerated(0.07) | possibly_damaging(0.621) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
WRAP53 | SNV | Missense_Mutation | novel | c.1418N>G | p.Leu473Arg | p.L473R | Q9BUR4 | protein_coding | deleterious(0) | benign(0.138) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WRAP53 | SNV | Missense_Mutation | novel | c.1022N>T | p.Ala341Val | p.A341V | Q9BUR4 | protein_coding | deleterious(0.02) | probably_damaging(0.921) | TCGA-NJ-A55A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |