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Gene: WDYHV1 |
Gene summary for WDYHV1 |
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Gene information | Species | Human | Gene symbol | WDYHV1 | Gene ID | 55093 |
Gene name | N-terminal glutamine amidase 1 | |
Gene Alias | C8orf32 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96HA8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55093 | WDYHV1 | LZE2T | Human | Esophagus | ESCC | 3.21e-02 | 3.70e-01 | 0.082 |
55093 | WDYHV1 | LZE4T | Human | Esophagus | ESCC | 9.15e-10 | 2.16e-01 | 0.0811 |
55093 | WDYHV1 | LZE7T | Human | Esophagus | ESCC | 1.50e-03 | 2.72e-01 | 0.0667 |
55093 | WDYHV1 | LZE8T | Human | Esophagus | ESCC | 4.60e-08 | 2.61e-01 | 0.067 |
55093 | WDYHV1 | LZE20T | Human | Esophagus | ESCC | 1.68e-03 | 2.36e-01 | 0.0662 |
55093 | WDYHV1 | LZE22T | Human | Esophagus | ESCC | 1.35e-04 | 2.35e-01 | 0.068 |
55093 | WDYHV1 | LZE24T | Human | Esophagus | ESCC | 9.63e-13 | 3.76e-01 | 0.0596 |
55093 | WDYHV1 | LZE6T | Human | Esophagus | ESCC | 3.64e-05 | 2.21e-01 | 0.0845 |
55093 | WDYHV1 | P1T-E | Human | Esophagus | ESCC | 3.16e-04 | 1.96e-01 | 0.0875 |
55093 | WDYHV1 | P2T-E | Human | Esophagus | ESCC | 4.25e-25 | 4.18e-01 | 0.1177 |
55093 | WDYHV1 | P4T-E | Human | Esophagus | ESCC | 4.13e-14 | 3.58e-01 | 0.1323 |
55093 | WDYHV1 | P5T-E | Human | Esophagus | ESCC | 2.93e-20 | 3.03e-01 | 0.1327 |
55093 | WDYHV1 | P8T-E | Human | Esophagus | ESCC | 1.74e-06 | 1.47e-01 | 0.0889 |
55093 | WDYHV1 | P9T-E | Human | Esophagus | ESCC | 3.24e-21 | 4.65e-01 | 0.1131 |
55093 | WDYHV1 | P10T-E | Human | Esophagus | ESCC | 1.89e-18 | 2.67e-01 | 0.116 |
55093 | WDYHV1 | P11T-E | Human | Esophagus | ESCC | 4.91e-12 | 3.95e-01 | 0.1426 |
55093 | WDYHV1 | P12T-E | Human | Esophagus | ESCC | 5.57e-22 | 4.42e-01 | 0.1122 |
55093 | WDYHV1 | P15T-E | Human | Esophagus | ESCC | 2.31e-25 | 5.07e-01 | 0.1149 |
55093 | WDYHV1 | P16T-E | Human | Esophagus | ESCC | 1.23e-31 | 6.01e-01 | 0.1153 |
55093 | WDYHV1 | P17T-E | Human | Esophagus | ESCC | 1.96e-09 | 4.37e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDYHV1 | SNV | Missense_Mutation | c.392N>T | p.Arg131Ile | p.R131I | Q96HA8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
WDYHV1 | SNV | Missense_Mutation | c.304T>G | p.Leu102Val | p.L102V | Q96HA8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDYHV1 | SNV | Missense_Mutation | novel | c.256N>T | p.His86Tyr | p.H86Y | Q96HA8 | protein_coding | tolerated(0.52) | benign(0.162) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
WDYHV1 | SNV | Missense_Mutation | c.172N>C | p.Glu58Gln | p.E58Q | Q96HA8 | protein_coding | tolerated(0.11) | benign(0.283) | TCGA-18-3417-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
WDYHV1 | SNV | Missense_Mutation | novel | c.506N>C | p.Gly169Ala | p.G169A | Q96HA8 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDYHV1 | SNV | Missense_Mutation | novel | c.602N>C | p.Gly201Ala | p.G201A | Q96HA8 | protein_coding | tolerated(0.44) | benign(0.021) | TCGA-CQ-A4CI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
WDYHV1 | SNV | Missense_Mutation | rs764186305 | c.479N>T | p.Pro160Leu | p.P160L | Q96HA8 | protein_coding | deleterious(0) | benign(0.145) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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