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Gene: WDR44 |
Gene summary for WDR44 |
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Gene information | Species | Human | Gene symbol | WDR44 | Gene ID | 54521 |
Gene name | WD repeat domain 44 | |
Gene Alias | RAB11BP | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5JSH3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54521 | WDR44 | CCI_2 | Human | Cervix | CC | 1.46e-04 | 8.08e-01 | 0.5249 |
54521 | WDR44 | CCI_3 | Human | Cervix | CC | 3.35e-06 | 5.01e-01 | 0.516 |
54521 | WDR44 | T3 | Human | Cervix | CC | 2.68e-02 | 1.14e-01 | 0.1389 |
54521 | WDR44 | LZE4T | Human | Esophagus | ESCC | 4.35e-08 | 1.54e-01 | 0.0811 |
54521 | WDR44 | LZE7T | Human | Esophagus | ESCC | 1.08e-06 | 3.18e-01 | 0.0667 |
54521 | WDR44 | LZE24T | Human | Esophagus | ESCC | 3.35e-12 | 2.56e-01 | 0.0596 |
54521 | WDR44 | P1T-E | Human | Esophagus | ESCC | 4.92e-03 | 1.55e-01 | 0.0875 |
54521 | WDR44 | P2T-E | Human | Esophagus | ESCC | 1.95e-13 | 1.84e-01 | 0.1177 |
54521 | WDR44 | P4T-E | Human | Esophagus | ESCC | 3.86e-06 | 1.14e-01 | 0.1323 |
54521 | WDR44 | P5T-E | Human | Esophagus | ESCC | 1.13e-04 | 8.77e-02 | 0.1327 |
54521 | WDR44 | P8T-E | Human | Esophagus | ESCC | 3.38e-11 | 1.06e-01 | 0.0889 |
54521 | WDR44 | P9T-E | Human | Esophagus | ESCC | 4.81e-07 | 1.40e-01 | 0.1131 |
54521 | WDR44 | P10T-E | Human | Esophagus | ESCC | 1.91e-02 | 1.17e-01 | 0.116 |
54521 | WDR44 | P11T-E | Human | Esophagus | ESCC | 1.24e-06 | 3.14e-01 | 0.1426 |
54521 | WDR44 | P12T-E | Human | Esophagus | ESCC | 1.16e-07 | 1.56e-01 | 0.1122 |
54521 | WDR44 | P15T-E | Human | Esophagus | ESCC | 1.66e-11 | 2.25e-01 | 0.1149 |
54521 | WDR44 | P16T-E | Human | Esophagus | ESCC | 4.72e-05 | 3.55e-02 | 0.1153 |
54521 | WDR44 | P20T-E | Human | Esophagus | ESCC | 1.31e-12 | 1.72e-01 | 0.1124 |
54521 | WDR44 | P21T-E | Human | Esophagus | ESCC | 5.30e-20 | 3.27e-01 | 0.1617 |
54521 | WDR44 | P22T-E | Human | Esophagus | ESCC | 7.22e-09 | 1.33e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR44 | SNV | Missense_Mutation | novel | c.43N>A | p.Glu15Lys | p.E15K | Q5JSH3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.985) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR44 | SNV | Missense_Mutation | c.2534N>T | p.Ser845Leu | p.S845L | Q5JSH3 | protein_coding | deleterious(0.04) | benign(0.441) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
WDR44 | SNV | Missense_Mutation | novel | c.2018N>A | p.Arg673His | p.R673H | Q5JSH3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
WDR44 | insertion | Frame_Shift_Ins | novel | c.1827_1828insTTACTACTTAG | p.Asp612LeufsTer40 | p.D612Lfs*40 | Q5JSH3 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
WDR44 | deletion | Frame_Shift_Del | c.1620delN | p.Asn542MetfsTer11 | p.N542Mfs*11 | Q5JSH3 | protein_coding | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
WDR44 | SNV | Missense_Mutation | c.2017C>T | p.Arg673Cys | p.R673C | Q5JSH3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR44 | SNV | Missense_Mutation | c.1721N>T | p.Ser574Leu | p.S574L | Q5JSH3 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WDR44 | SNV | Missense_Mutation | c.1945N>G | p.Phe649Val | p.F649V | Q5JSH3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WDR44 | SNV | Missense_Mutation | novel | c.1637N>T | p.Tyr546Phe | p.Y546F | Q5JSH3 | protein_coding | tolerated(0.22) | benign(0.042) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
WDR44 | SNV | Missense_Mutation | rs763934302 | c.1628C>T | p.Ala543Val | p.A543V | Q5JSH3 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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