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Gene: WDR34 |
Gene summary for WDR34 |
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Gene information | Species | Human | Gene symbol | WDR34 | Gene ID | 89891 |
Gene name | dynein 2 intermediate chain 2 | |
Gene Alias | CFAP133 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q96EX3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89891 | WDR34 | GSM4909281 | Human | Breast | IDC | 3.75e-04 | 2.71e-01 | 0.21 |
89891 | WDR34 | GSM4909282 | Human | Breast | IDC | 3.09e-03 | 2.92e-01 | -0.0288 |
89891 | WDR34 | GSM4909285 | Human | Breast | IDC | 1.02e-11 | 3.30e-01 | 0.21 |
89891 | WDR34 | GSM4909290 | Human | Breast | IDC | 1.54e-02 | 2.37e-01 | 0.2096 |
89891 | WDR34 | GSM4909291 | Human | Breast | IDC | 3.58e-18 | 5.92e-01 | 0.1753 |
89891 | WDR34 | GSM4909295 | Human | Breast | IDC | 3.49e-03 | 3.24e-01 | 0.0898 |
89891 | WDR34 | GSM4909308 | Human | Breast | IDC | 4.64e-02 | 1.88e-01 | 0.158 |
89891 | WDR34 | GSM4909311 | Human | Breast | IDC | 1.82e-04 | -6.40e-02 | 0.1534 |
89891 | WDR34 | GSM4909317 | Human | Breast | IDC | 9.97e-06 | 2.57e-01 | 0.1355 |
89891 | WDR34 | GSM4909319 | Human | Breast | IDC | 7.68e-10 | -1.05e-02 | 0.1563 |
89891 | WDR34 | GSM4909321 | Human | Breast | IDC | 2.38e-02 | 3.80e-02 | 0.1559 |
89891 | WDR34 | brca2 | Human | Breast | Precancer | 3.56e-02 | 1.58e-01 | -0.024 |
89891 | WDR34 | M1 | Human | Breast | IDC | 3.92e-04 | 2.79e-01 | 0.1577 |
89891 | WDR34 | NCCBC5 | Human | Breast | DCIS | 1.79e-03 | 1.95e-01 | 0.2046 |
89891 | WDR34 | P2 | Human | Breast | IDC | 7.52e-11 | 5.54e-01 | 0.21 |
89891 | WDR34 | DCIS2 | Human | Breast | DCIS | 7.56e-24 | 4.57e-02 | 0.0085 |
89891 | WDR34 | LZE4T | Human | Esophagus | ESCC | 1.69e-04 | 9.25e-02 | 0.0811 |
89891 | WDR34 | LZE7T | Human | Esophagus | ESCC | 6.34e-12 | 8.39e-01 | 0.0667 |
89891 | WDR34 | LZE8T | Human | Esophagus | ESCC | 2.34e-02 | 2.37e-01 | 0.067 |
89891 | WDR34 | LZE20T | Human | Esophagus | ESCC | 4.06e-07 | 2.69e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR34 | SNV | Missense_Mutation | rs201326058 | c.1118G>A | p.Arg373Gln | p.R373Q | Q96EX3 | protein_coding | tolerated(0.26) | benign(0.014) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WDR34 | SNV | Missense_Mutation | rs147957478 | c.391N>A | p.Ala131Thr | p.A131T | Q96EX3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
WDR34 | SNV | Missense_Mutation | novel | c.562N>C | p.Trp188Arg | p.W188R | Q96EX3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-PG-A6IB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR34 | SNV | Missense_Mutation | novel | c.1396C>A | p.Gln466Lys | p.Q466K | Q96EX3 | protein_coding | tolerated(0.98) | benign(0.001) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
WDR34 | SNV | Missense_Mutation | c.244N>T | p.His82Tyr | p.H82Y | Q96EX3 | protein_coding | tolerated(0.75) | benign(0.043) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
WDR34 | SNV | Missense_Mutation | novel | c.509N>G | p.Asn170Ser | p.N170S | Q96EX3 | protein_coding | tolerated(0.2) | benign(0.215) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR34 | SNV | Missense_Mutation | novel | c.1595C>A | p.Ala532Glu | p.A532E | Q96EX3 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-CQ-5332-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
WDR34 | SNV | Missense_Mutation | rs11541003 | c.847N>T | p.Arg283Cys | p.R283C | Q96EX3 | protein_coding | deleterious(0.04) | possibly_damaging(0.892) | TCGA-HD-7229-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
WDR34 | SNV | Missense_Mutation | c.530N>T | p.Ala177Val | p.A177V | Q96EX3 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR34 | SNV | Missense_Mutation | rs749760692 | c.1436N>T | p.Thr479Ile | p.T479I | Q96EX3 | protein_coding | tolerated(0.15) | benign(0.229) | TCGA-CG-4438-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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