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Gene: VGLL1 |
Gene summary for VGLL1 |
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Gene information | Species | Human | Gene symbol | VGLL1 | Gene ID | 51442 |
Gene name | vestigial like family member 1 | |
Gene Alias | TDU | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99990 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51442 | VGLL1 | P8T-E | Human | Esophagus | ESCC | 3.88e-09 | 3.19e-01 | 0.0889 |
51442 | VGLL1 | P39T-E | Human | Esophagus | ESCC | 3.60e-13 | 5.82e-01 | 0.0894 |
51442 | VGLL1 | P74T-E | Human | Esophagus | ESCC | 1.96e-03 | 2.21e-01 | 0.1479 |
51442 | VGLL1 | P82T-E | Human | Esophagus | ESCC | 1.13e-10 | 9.94e-01 | 0.1072 |
51442 | VGLL1 | P84T-E | Human | Esophagus | ESCC | 8.33e-03 | 4.18e-01 | 0.0933 |
51442 | VGLL1 | P127T-E | Human | Esophagus | ESCC | 8.31e-06 | 2.35e-01 | 0.0826 |
51442 | VGLL1 | P130T-E | Human | Esophagus | ESCC | 8.96e-45 | 1.14e+00 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VGLL1 | SNV | Missense_Mutation | novel | c.217G>T | p.Asp73Tyr | p.D73Y | Q99990 | protein_coding | deleterious(0.01) | benign(0.187) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
VGLL1 | SNV | Missense_Mutation | novel | c.383G>T | p.Gly128Val | p.G128V | Q99990 | protein_coding | tolerated(0.18) | benign(0.125) | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VGLL1 | SNV | Missense_Mutation | novel | c.746G>T | p.Gly249Val | p.G249V | Q99990 | protein_coding | deleterious_low_confidence(0.02) | benign(0.175) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VGLL1 | SNV | Missense_Mutation | c.547G>A | p.Glu183Lys | p.E183K | Q99990 | protein_coding | deleterious(0.03) | benign(0.063) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VGLL1 | SNV | Missense_Mutation | novel | c.676C>T | p.Leu226Phe | p.L226F | Q99990 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-2Y-A9GU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VGLL1 | SNV | Missense_Mutation | novel | c.481N>G | p.Pro161Ala | p.P161A | Q99990 | protein_coding | deleterious(0.02) | benign(0.299) | TCGA-2Y-A9H9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | sorafenib | PD |
VGLL1 | SNV | Missense_Mutation | c.328N>T | p.Met110Leu | p.M110L | Q99990 | protein_coding | tolerated(0.4) | benign(0) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VGLL1 | SNV | Missense_Mutation | c.106N>T | p.Asp36Tyr | p.D36Y | Q99990 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
VGLL1 | SNV | Missense_Mutation | novel | c.367G>T | p.Ala123Ser | p.A123S | Q99990 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-73-4662-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
VGLL1 | SNV | Missense_Mutation | c.115A>T | p.Ser39Cys | p.S39C | Q99990 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-73-4670-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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