![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: USP46 |
Gene summary for USP46 |
![]() |
Gene information | Species | Human | Gene symbol | USP46 | Gene ID | 64854 |
Gene name | ubiquitin specific peptidase 46 | |
Gene Alias | USP46 | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0001662 | UniProtAcc | P62068 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64854 | USP46 | LZE4T | Human | Esophagus | ESCC | 1.36e-08 | 3.27e-01 | 0.0811 |
64854 | USP46 | LZE7T | Human | Esophagus | ESCC | 1.00e-04 | 3.62e-01 | 0.0667 |
64854 | USP46 | LZE8T | Human | Esophagus | ESCC | 1.40e-06 | 1.91e-01 | 0.067 |
64854 | USP46 | LZE24T | Human | Esophagus | ESCC | 1.12e-07 | 1.93e-01 | 0.0596 |
64854 | USP46 | P2T-E | Human | Esophagus | ESCC | 5.36e-32 | 5.21e-01 | 0.1177 |
64854 | USP46 | P4T-E | Human | Esophagus | ESCC | 1.86e-11 | 2.26e-01 | 0.1323 |
64854 | USP46 | P5T-E | Human | Esophagus | ESCC | 2.81e-05 | 1.59e-01 | 0.1327 |
64854 | USP46 | P8T-E | Human | Esophagus | ESCC | 2.02e-16 | 3.01e-01 | 0.0889 |
64854 | USP46 | P9T-E | Human | Esophagus | ESCC | 2.50e-10 | 1.74e-01 | 0.1131 |
64854 | USP46 | P10T-E | Human | Esophagus | ESCC | 8.62e-22 | 3.34e-01 | 0.116 |
64854 | USP46 | P11T-E | Human | Esophagus | ESCC | 1.10e-10 | 3.23e-01 | 0.1426 |
64854 | USP46 | P12T-E | Human | Esophagus | ESCC | 9.45e-16 | 3.54e-01 | 0.1122 |
64854 | USP46 | P15T-E | Human | Esophagus | ESCC | 1.53e-19 | 2.88e-01 | 0.1149 |
64854 | USP46 | P16T-E | Human | Esophagus | ESCC | 3.83e-17 | 3.51e-01 | 0.1153 |
64854 | USP46 | P17T-E | Human | Esophagus | ESCC | 1.67e-06 | 2.00e-01 | 0.1278 |
64854 | USP46 | P20T-E | Human | Esophagus | ESCC | 4.51e-09 | 1.79e-01 | 0.1124 |
64854 | USP46 | P21T-E | Human | Esophagus | ESCC | 3.62e-09 | 1.42e-01 | 0.1617 |
64854 | USP46 | P22T-E | Human | Esophagus | ESCC | 2.40e-21 | 3.57e-01 | 0.1236 |
64854 | USP46 | P23T-E | Human | Esophagus | ESCC | 1.36e-15 | 2.57e-01 | 0.108 |
64854 | USP46 | P24T-E | Human | Esophagus | ESCC | 9.17e-07 | 1.22e-01 | 0.1287 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:004311218 | Esophagus | ESCC | receptor metabolic process | 104/8552 | 166/18723 | 7.44e-06 | 7.37e-05 | 104 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:004825916 | Esophagus | ESCC | regulation of receptor-mediated endocytosis | 66/8552 | 110/18723 | 1.72e-03 | 7.96e-03 | 66 |
GO:0097305111 | Esophagus | ESCC | response to alcohol | 138/8552 | 253/18723 | 2.70e-03 | 1.14e-02 | 138 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:003010020 | Thyroid | PTC | regulation of endocytosis | 108/5968 | 211/18723 | 3.92e-09 | 1.04e-07 | 108 |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:0006898110 | Thyroid | PTC | receptor-mediated endocytosis | 112/5968 | 244/18723 | 2.87e-06 | 3.74e-05 | 112 |
GO:004825918 | Thyroid | PTC | regulation of receptor-mediated endocytosis | 55/5968 | 110/18723 | 5.64e-05 | 4.99e-04 | 55 |
GO:004311219 | Thyroid | PTC | receptor metabolic process | 77/5968 | 166/18723 | 6.21e-05 | 5.47e-04 | 77 |
GO:0097305113 | Thyroid | PTC | response to alcohol | 107/5968 | 253/18723 | 2.92e-04 | 2.07e-03 | 107 |
GO:00706465 | Thyroid | PTC | protein modification by small protein removal | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
GO:00165794 | Thyroid | PTC | protein deubiquitination | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:0030100111 | Thyroid | ATC | regulation of endocytosis | 113/6293 | 211/18723 | 1.71e-09 | 4.22e-08 | 113 |
GO:000689826 | Thyroid | ATC | receptor-mediated endocytosis | 118/6293 | 244/18723 | 1.17e-06 | 1.50e-05 | 118 |
GO:003150316 | Thyroid | ATC | protein-containing complex localization | 108/6293 | 220/18723 | 1.33e-06 | 1.69e-05 | 108 |
GO:004311224 | Thyroid | ATC | receptor metabolic process | 82/6293 | 166/18723 | 1.78e-05 | 1.63e-04 | 82 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP46 | SNV | Missense_Mutation | novel | c.579A>C | p.Glu193Asp | p.E193D | P62068 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP46 | SNV | Missense_Mutation | novel | c.34N>G | p.Met12Val | p.M12V | P62068 | protein_coding | deleterious(0.03) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP46 | SNV | Missense_Mutation | novel | c.710A>G | p.Glu237Gly | p.E237G | P62068 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
USP46 | SNV | Missense_Mutation | c.244N>A | p.Asp82Asn | p.D82N | P62068 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
USP46 | SNV | Missense_Mutation | novel | c.622A>G | p.Ile208Val | p.I208V | P62068 | protein_coding | tolerated(0.8) | probably_damaging(0.999) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP46 | SNV | Missense_Mutation | rs754020803 | c.178N>T | p.Arg60Trp | p.R60W | P62068 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP46 | SNV | Missense_Mutation | rs548395753 | c.647N>A | p.Ser216Asn | p.S216N | P62068 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
USP46 | SNV | Missense_Mutation | novel | c.197N>G | p.Tyr66Cys | p.Y66C | P62068 | protein_coding | deleterious(0) | possibly_damaging(0.708) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
USP46 | SNV | Missense_Mutation | c.216N>T | p.Lys72Asn | p.K72N | P62068 | protein_coding | tolerated(0.12) | benign(0.103) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
USP46 | SNV | Missense_Mutation | c.727A>T | p.Arg243Trp | p.R243W | P62068 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-05-4430-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |