![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: USP32 |
Gene summary for USP32 |
![]() |
Gene information | Species | Human | Gene symbol | USP32 | Gene ID | 84669 |
Gene name | ubiquitin specific peptidase 32 | |
Gene Alias | NY-REN-60 | |
Cytomap | 17q23.1-q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NFA0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84669 | USP32 | CCI_1 | Human | Cervix | CC | 7.75e-06 | 7.71e-01 | 0.528 |
84669 | USP32 | CCI_2 | Human | Cervix | CC | 2.53e-07 | 9.00e-01 | 0.5249 |
84669 | USP32 | CCI_3 | Human | Cervix | CC | 4.92e-11 | 6.58e-01 | 0.516 |
84669 | USP32 | CCII_1 | Human | Cervix | CC | 3.73e-03 | 3.38e-01 | 0.3249 |
84669 | USP32 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.24e-07 | -4.41e-01 | 0.0155 |
84669 | USP32 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.25e-04 | -3.74e-01 | 0.096 |
84669 | USP32 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.66e-06 | -3.21e-01 | 0.0674 |
84669 | USP32 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.14e-02 | -1.92e-01 | 0.3859 |
84669 | USP32 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.08e-09 | -4.04e-01 | 0.3005 |
84669 | USP32 | A002-C-010 | Human | Colorectum | FAP | 5.99e-04 | -1.83e-01 | 0.242 |
84669 | USP32 | A001-C-207 | Human | Colorectum | FAP | 4.07e-03 | -2.58e-01 | 0.1278 |
84669 | USP32 | A015-C-203 | Human | Colorectum | FAP | 4.30e-25 | -3.67e-01 | -0.1294 |
84669 | USP32 | A015-C-204 | Human | Colorectum | FAP | 4.33e-03 | -2.18e-01 | -0.0228 |
84669 | USP32 | A014-C-040 | Human | Colorectum | FAP | 1.10e-03 | -2.29e-01 | -0.1184 |
84669 | USP32 | A002-C-201 | Human | Colorectum | FAP | 2.42e-13 | -3.69e-01 | 0.0324 |
84669 | USP32 | A002-C-203 | Human | Colorectum | FAP | 6.01e-05 | -2.04e-01 | 0.2786 |
84669 | USP32 | A001-C-119 | Human | Colorectum | FAP | 1.18e-04 | -2.44e-01 | -0.1557 |
84669 | USP32 | A001-C-108 | Human | Colorectum | FAP | 8.27e-12 | -2.35e-01 | -0.0272 |
84669 | USP32 | A002-C-205 | Human | Colorectum | FAP | 4.04e-19 | -3.87e-01 | -0.1236 |
84669 | USP32 | A001-C-104 | Human | Colorectum | FAP | 8.94e-04 | -2.26e-01 | 0.0184 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP32 | SNV | Missense_Mutation | c.1295N>T | p.Ser432Leu | p.S432L | Q8NFA0 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
USP32 | SNV | Missense_Mutation | c.1310N>T | p.Ala437Val | p.A437V | Q8NFA0 | protein_coding | tolerated(0.35) | benign(0) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | novel | c.506N>G | p.Tyr169Cys | p.Y169C | Q8NFA0 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
USP32 | SNV | Missense_Mutation | novel | c.2972N>G | p.Phe991Cys | p.F991C | Q8NFA0 | protein_coding | tolerated(0.17) | possibly_damaging(0.677) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | c.4564C>A | p.Leu1522Met | p.L1522M | Q8NFA0 | protein_coding | tolerated(0.29) | benign(0.022) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
USP32 | SNV | Missense_Mutation | c.297T>G | p.Ile99Met | p.I99M | Q8NFA0 | protein_coding | deleterious(0.01) | benign(0.115) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
USP32 | SNV | Missense_Mutation | rs202121527 | c.3362N>T | p.Ala1121Val | p.A1121V | Q8NFA0 | protein_coding | tolerated(0.16) | possibly_damaging(0.788) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
USP32 | SNV | Missense_Mutation | c.621N>C | p.Lys207Asn | p.K207N | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AU-3779-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | c.4213N>T | p.Ser1405Cys | p.S1405C | Q8NFA0 | protein_coding | tolerated_low_confidence(0.05) | possibly_damaging(0.65) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | rs749641360 | c.1978N>T | p.Arg660Cys | p.R660C | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AY-A71X-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |