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Gene: TXK |
Gene summary for TXK |
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Gene information | Species | Human | Gene symbol | TXK | Gene ID | 7294 |
Gene name | TXK tyrosine kinase | |
Gene Alias | BTKL | |
Cytomap | 4p12 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P42681 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7294 | TXK | AEH-subject1 | Human | Endometrium | AEH | 1.92e-03 | 2.39e-01 | -0.3059 |
7294 | TXK | AEH-subject3 | Human | Endometrium | AEH | 1.53e-03 | 2.61e-01 | -0.2576 |
7294 | TXK | AEH-subject5 | Human | Endometrium | AEH | 2.21e-25 | 6.75e-01 | -0.2953 |
7294 | TXK | EEC-subject1 | Human | Endometrium | EEC | 3.54e-19 | 5.74e-01 | -0.2682 |
7294 | TXK | EEC-subject2 | Human | Endometrium | EEC | 7.62e-03 | 2.04e-01 | -0.2607 |
7294 | TXK | EEC-subject4 | Human | Endometrium | EEC | 2.34e-12 | 4.04e-01 | -0.2571 |
7294 | TXK | EEC-subject5 | Human | Endometrium | EEC | 2.46e-20 | 5.33e-01 | -0.249 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206016 | Endometrium | AEH | wound healing | 91/2100 | 422/18723 | 4.85e-10 | 4.61e-08 | 91 |
GO:00072296 | Endometrium | AEH | integrin-mediated signaling pathway | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:00310997 | Endometrium | AEH | regeneration | 41/2100 | 198/18723 | 7.29e-05 | 1.11e-03 | 41 |
GO:00075967 | Endometrium | AEH | blood coagulation | 43/2100 | 217/18723 | 1.42e-04 | 1.89e-03 | 43 |
GO:00075997 | Endometrium | AEH | hemostasis | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:00508177 | Endometrium | AEH | coagulation | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:005087815 | Endometrium | AEH | regulation of body fluid levels | 64/2100 | 379/18723 | 5.40e-04 | 5.44e-03 | 64 |
GO:00027645 | Endometrium | AEH | immune response-regulating signaling pathway | 76/2100 | 468/18723 | 5.76e-04 | 5.71e-03 | 76 |
GO:00508525 | Endometrium | AEH | T cell receptor signaling pathway | 26/2100 | 123/18723 | 1.03e-03 | 9.15e-03 | 26 |
GO:00321036 | Endometrium | AEH | positive regulation of response to external stimulus | 68/2100 | 427/18723 | 1.82e-03 | 1.44e-02 | 68 |
GO:00301683 | Endometrium | AEH | platelet activation | 25/2100 | 123/18723 | 2.26e-03 | 1.74e-02 | 25 |
GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
GO:004206017 | Endometrium | EEC | wound healing | 92/2168 | 422/18723 | 1.12e-09 | 9.58e-08 | 92 |
GO:000722914 | Endometrium | EEC | integrin-mediated signaling pathway | 32/2168 | 107/18723 | 2.58e-07 | 1.10e-05 | 32 |
GO:003109914 | Endometrium | EEC | regeneration | 45/2168 | 198/18723 | 6.19e-06 | 1.49e-04 | 45 |
GO:000759613 | Endometrium | EEC | blood coagulation | 44/2168 | 217/18723 | 1.42e-04 | 1.84e-03 | 44 |
GO:000276412 | Endometrium | EEC | immune response-regulating signaling pathway | 80/2168 | 468/18723 | 2.20e-04 | 2.64e-03 | 80 |
GO:000759913 | Endometrium | EEC | hemostasis | 44/2168 | 222/18723 | 2.43e-04 | 2.85e-03 | 44 |
GO:005081713 | Endometrium | EEC | coagulation | 44/2168 | 222/18723 | 2.43e-04 | 2.85e-03 | 44 |
GO:005087816 | Endometrium | EEC | regulation of body fluid levels | 65/2168 | 379/18723 | 7.48e-04 | 7.05e-03 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0467026 | Endometrium | AEH | Leukocyte transendothelial migration | 37/1197 | 114/8465 | 4.51e-07 | 6.11e-06 | 4.47e-06 | 37 |
hsa04670111 | Endometrium | AEH | Leukocyte transendothelial migration | 37/1197 | 114/8465 | 4.51e-07 | 6.11e-06 | 4.47e-06 | 37 |
hsa0467027 | Endometrium | EEC | Leukocyte transendothelial migration | 36/1237 | 114/8465 | 2.97e-06 | 3.91e-05 | 2.91e-05 | 36 |
hsa0467036 | Endometrium | EEC | Leukocyte transendothelial migration | 36/1237 | 114/8465 | 2.97e-06 | 3.91e-05 | 2.91e-05 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXK | SNV | Missense_Mutation | novel | c.423N>C | p.Lys141Asn | p.K141N | P42681 | protein_coding | tolerated(0.16) | benign(0.258) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TXK | SNV | Missense_Mutation | novel | c.687G>T | p.Trp229Cys | p.W229C | P42681 | protein_coding | tolerated(0.14) | benign(0.276) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TXK | SNV | Missense_Mutation | rs758178726 | c.518T>G | p.Phe173Cys | p.F173C | P42681 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TXK | SNV | Missense_Mutation | novel | c.502T>A | p.Ser168Thr | p.S168T | P42681 | protein_coding | tolerated(0.09) | benign(0.155) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TXK | SNV | Missense_Mutation | c.1459N>A | p.Arg487Ser | p.R487S | P42681 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TXK | SNV | Missense_Mutation | c.289N>A | p.Glu97Lys | p.E97K | P42681 | protein_coding | tolerated(0.08) | benign(0.199) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TXK | SNV | Missense_Mutation | c.653N>T | p.Arg218Ile | p.R218I | P42681 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TXK | SNV | Missense_Mutation | rs756580244 | c.728G>A | p.Arg243Gln | p.R243Q | P42681 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TXK | SNV | Missense_Mutation | c.683N>C | p.Ile228Thr | p.I228T | P42681 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
TXK | SNV | Missense_Mutation | rs776450131 | c.206N>A | p.Arg69Gln | p.R69Q | P42681 | protein_coding | tolerated(0.06) | benign(0.054) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 178102336 | BOSUTINIB | |
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 249565828 | ||
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 318164804 | ||
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 354702234 | ||
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 178103494 | IBRUTINIB | |
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 249565852 | ||
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 249565825 | ||
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 310264693 | ACALABRUTINIB | |
7294 | TXK | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, ENZYME | inhibitor | 249565826 |
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