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Gene: TTLL1 |
Gene summary for TTLL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTLL1 | Gene ID | 25809 |
| Gene name | tubulin tyrosine ligase like 1 | |
| Gene Alias | C22orf7 | |
| Cytomap | 22q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R4U6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 25809 | TTLL1 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 2.95e-01 | 0.082 |
| 25809 | TTLL1 | LZE24T | Human | Esophagus | ESCC | 1.68e-09 | 2.46e-01 | 0.0596 |
| 25809 | TTLL1 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.71e-01 | 0.0875 |
| 25809 | TTLL1 | P2T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.28e-01 | 0.1177 |
| 25809 | TTLL1 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.36e-01 | 0.1323 |
| 25809 | TTLL1 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.82e-02 | 0.0889 |
| 25809 | TTLL1 | P10T-E | Human | Esophagus | ESCC | 2.39e-24 | 3.88e-01 | 0.116 |
| 25809 | TTLL1 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.49e-01 | 0.1426 |
| 25809 | TTLL1 | P12T-E | Human | Esophagus | ESCC | 3.89e-12 | 1.83e-01 | 0.1122 |
| 25809 | TTLL1 | P15T-E | Human | Esophagus | ESCC | 1.32e-06 | 1.67e-01 | 0.1149 |
| 25809 | TTLL1 | P16T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.29e-01 | 0.1153 |
| 25809 | TTLL1 | P21T-E | Human | Esophagus | ESCC | 3.63e-05 | 9.01e-02 | 0.1617 |
| 25809 | TTLL1 | P22T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.40e-01 | 0.1236 |
| 25809 | TTLL1 | P23T-E | Human | Esophagus | ESCC | 9.87e-03 | 1.13e-01 | 0.108 |
| 25809 | TTLL1 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.92e-02 | 0.1287 |
| 25809 | TTLL1 | P26T-E | Human | Esophagus | ESCC | 9.02e-11 | 1.99e-01 | 0.1276 |
| 25809 | TTLL1 | P27T-E | Human | Esophagus | ESCC | 3.89e-12 | 1.97e-01 | 0.1055 |
| 25809 | TTLL1 | P30T-E | Human | Esophagus | ESCC | 1.89e-05 | 2.02e-01 | 0.137 |
| 25809 | TTLL1 | P31T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.35e-01 | 0.1251 |
| 25809 | TTLL1 | P32T-E | Human | Esophagus | ESCC | 8.84e-05 | 9.79e-02 | 0.1666 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0034340 | Colorectum | AD | response to type I interferon | 22/3918 | 58/18723 | 2.23e-03 | 1.75e-02 | 22 |
| GO:0060337 | Colorectum | AD | type I interferon signaling pathway | 19/3918 | 50/18723 | 4.23e-03 | 2.91e-02 | 19 |
| GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
| GO:0071357 | Colorectum | AD | cellular response to type I interferon | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
| GO:00343401 | Colorectum | SER | response to type I interferon | 17/2897 | 58/18723 | 5.50e-03 | 4.07e-02 | 17 |
| GO:00343402 | Colorectum | MSS | response to type I interferon | 20/3467 | 58/18723 | 2.82e-03 | 2.20e-02 | 20 |
| GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
| GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
| GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
| GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
| GO:00603375 | Esophagus | ESCC | type I interferon signaling pathway | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
| GO:00713575 | Esophagus | ESCC | cellular response to type I interferon | 42/8552 | 52/18723 | 2.15e-07 | 3.30e-06 | 42 |
| GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
| GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
| GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
| GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
| GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
| GO:00603385 | Esophagus | ESCC | regulation of type I interferon-mediated signaling pathway | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
| GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
| GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TTLL1 | SNV | Missense_Mutation | rs202042134 | c.986C>T | p.Ala329Val | p.A329V | O95922 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TTLL1 | SNV | Missense_Mutation | rs767006390 | c.817C>T | p.Arg273Cys | p.R273C | O95922 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TTLL1 | SNV | Missense_Mutation | rs6003030 | c.503C>T | p.Ser168Leu | p.S168L | O95922 | protein_coding | tolerated(0.16) | benign(0.041) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
| TTLL1 | SNV | Missense_Mutation | novel | c.1141N>A | p.Leu381Met | p.L381M | O95922 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| TTLL1 | SNV | Missense_Mutation | rs746847301 | c.847N>A | p.Asp283Asn | p.D283N | O95922 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| TTLL1 | SNV | Missense_Mutation | novel | c.218N>A | p.Arg73Gln | p.R73Q | O95922 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| TTLL1 | SNV | Missense_Mutation | rs770156420 | c.614C>T | p.Thr205Met | p.T205M | O95922 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TTLL1 | SNV | Missense_Mutation | rs867699587 | c.949N>A | p.Asp317Asn | p.D317N | O95922 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TTLL1 | SNV | Missense_Mutation | novel | c.1037N>G | p.Asn346Ser | p.N346S | O95922 | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| TTLL1 | SNV | Missense_Mutation | c.956A>C | p.Lys319Thr | p.K319T | O95922 | protein_coding | tolerated(0.33) | benign(0.014) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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