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Gene: TTC7A |
Gene summary for TTC7A |
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Gene information | Species | Human | Gene symbol | TTC7A | Gene ID | 57217 |
Gene name | tetratricopeptide repeat domain 7A | |
Gene Alias | GIDID | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9ULT0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57217 | TTC7A | CCI_1 | Human | Cervix | CC | 3.65e-06 | 6.64e-01 | 0.528 |
57217 | TTC7A | CCI_2 | Human | Cervix | CC | 2.45e-05 | 7.58e-01 | 0.5249 |
57217 | TTC7A | CCI_3 | Human | Cervix | CC | 7.00e-06 | 6.29e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00550726 | Cervix | CC | iron ion homeostasis | 19/2311 | 85/18723 | 6.88e-03 | 3.74e-02 | 19 |
GO:00550768 | Cervix | CC | transition metal ion homeostasis | 27/2311 | 138/18723 | 9.89e-03 | 4.85e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC7A | SNV | Missense_Mutation | c.1288N>A | p.Ser430Thr | p.S430T | Q9ULT0 | protein_coding | tolerated(0.11) | possibly_damaging(0.841) | TCGA-AA-3956-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TTC7A | SNV | Missense_Mutation | c.686N>A | p.Cys229Tyr | p.C229Y | Q9ULT0 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTC7A | SNV | Missense_Mutation | rs538380438 | c.2384C>T | p.Ala795Val | p.A795V | Q9ULT0 | protein_coding | deleterious(0.02) | possibly_damaging(0.604) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | rs773801843 | c.1387N>T | p.Arg463Cys | p.R463C | Q9ULT0 | protein_coding | deleterious(0) | benign(0.153) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | c.2145N>T | p.Glu715Asp | p.E715D | Q9ULT0 | protein_coding | tolerated(0.06) | probably_damaging(0.918) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TTC7A | SNV | Missense_Mutation | rs115234247 | c.347N>T | p.Ser116Leu | p.S116L | Q9ULT0 | protein_coding | tolerated(0.2) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TTC7A | SNV | Missense_Mutation | rs201734751 | c.557N>A | p.Arg186His | p.R186H | Q9ULT0 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | rs767380906 | c.487N>T | p.Arg163Trp | p.R163W | Q9ULT0 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | rs142490773 | c.1382N>T | p.Ser461Phe | p.S461F | Q9ULT0 | protein_coding | tolerated(0.6) | benign(0.44) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | novel | c.1655N>G | p.Met552Arg | p.M552R | Q9ULT0 | protein_coding | deleterious(0) | benign(0.054) | TCGA-DY-A1H8-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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