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Gene: TTC19 |
Gene summary for TTC19 |
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Gene information | Species | Human | Gene symbol | TTC19 | Gene ID | 54902 |
Gene name | tetratricopeptide repeat domain 19 | |
Gene Alias | 2010204O13Rik | |
Cytomap | 17p12 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q6DKK2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54902 | TTC19 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.65e-12 | -4.45e-01 | 0.0155 |
54902 | TTC19 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.64e-03 | -4.21e-01 | -0.1207 |
54902 | TTC19 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.88e-02 | -2.49e-01 | -0.1464 |
54902 | TTC19 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.04e-03 | -2.73e-01 | 0.096 |
54902 | TTC19 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.76e-02 | -3.49e-01 | 0.0338 |
54902 | TTC19 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.01e-03 | -3.05e-01 | 0.0674 |
54902 | TTC19 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.35e-04 | -3.41e-01 | 0.3859 |
54902 | TTC19 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.19e-04 | -4.93e-01 | 0.2585 |
54902 | TTC19 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.55e-06 | -3.63e-01 | 0.3005 |
54902 | TTC19 | A001-C-207 | Human | Colorectum | FAP | 1.31e-06 | -3.19e-01 | 0.1278 |
54902 | TTC19 | A015-C-203 | Human | Colorectum | FAP | 1.74e-27 | -4.88e-01 | -0.1294 |
54902 | TTC19 | A015-C-204 | Human | Colorectum | FAP | 2.31e-06 | -2.83e-01 | -0.0228 |
54902 | TTC19 | A014-C-040 | Human | Colorectum | FAP | 1.48e-05 | -4.34e-01 | -0.1184 |
54902 | TTC19 | A002-C-201 | Human | Colorectum | FAP | 7.24e-17 | -4.14e-01 | 0.0324 |
54902 | TTC19 | A002-C-203 | Human | Colorectum | FAP | 2.97e-03 | -1.78e-01 | 0.2786 |
54902 | TTC19 | A001-C-119 | Human | Colorectum | FAP | 2.81e-09 | -3.96e-01 | -0.1557 |
54902 | TTC19 | A001-C-108 | Human | Colorectum | FAP | 3.26e-14 | -2.35e-01 | -0.0272 |
54902 | TTC19 | A002-C-205 | Human | Colorectum | FAP | 8.85e-24 | -4.21e-01 | -0.1236 |
54902 | TTC19 | A001-C-104 | Human | Colorectum | FAP | 9.58e-03 | -1.64e-01 | 0.0184 |
54902 | TTC19 | A015-C-005 | Human | Colorectum | FAP | 1.47e-05 | -2.41e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0000281 | Colorectum | AD | mitotic cytokinesis | 25/3918 | 71/18723 | 3.77e-03 | 2.65e-02 | 25 |
GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
GO:00009102 | Colorectum | MSS | cytokinesis | 49/3467 | 173/18723 | 1.02e-03 | 1.02e-02 | 49 |
GO:00002811 | Colorectum | MSS | mitotic cytokinesis | 23/3467 | 71/18723 | 3.55e-03 | 2.63e-02 | 23 |
GO:00009103 | Colorectum | FAP | cytokinesis | 37/2622 | 173/18723 | 5.10e-03 | 3.37e-02 | 37 |
GO:00009104 | Colorectum | CRC | cytokinesis | 34/2078 | 173/18723 | 6.47e-04 | 8.55e-03 | 34 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:00009106 | Lung | IAC | cytokinesis | 31/2061 | 173/18723 | 4.28e-03 | 3.41e-02 | 31 |
GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
GO:00170043 | Oral cavity | OSCC | cytochrome complex assembly | 31/7305 | 36/18723 | 7.28e-09 | 1.53e-07 | 31 |
GO:00002815 | Oral cavity | OSCC | mitotic cytokinesis | 51/7305 | 71/18723 | 2.01e-08 | 3.95e-07 | 51 |
GO:000091010 | Oral cavity | OSCC | cytokinesis | 97/7305 | 173/18723 | 3.82e-06 | 4.51e-05 | 97 |
GO:00616405 | Oral cavity | OSCC | cytoskeleton-dependent cytokinesis | 60/7305 | 100/18723 | 1.69e-05 | 1.67e-04 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC19 | SNV | Missense_Mutation | novel | c.976N>A | p.Ala326Thr | p.A326T | Q6DKK2 | protein_coding | deleterious(0.01) | benign(0.212) | TCGA-BA-4075-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
TTC19 | SNV | Missense_Mutation | rs761032812 | c.428N>T | p.Ala143Val | p.A143V | Q6DKK2 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC19 | SNV | Missense_Mutation | c.731N>T | p.Ala244Val | p.A244V | Q6DKK2 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TTC19 | SNV | Missense_Mutation | novel | c.490A>T | p.Ser164Cys | p.S164C | Q6DKK2 | protein_coding | deleterious(0) | benign(0.119) | TCGA-RD-A8MW-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
TTC19 | SNV | Missense_Mutation | rs762239880 | c.724N>A | p.Ala242Thr | p.A242T | Q6DKK2 | protein_coding | tolerated(0.21) | benign(0.019) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
TTC19 | SNV | Missense_Mutation | rs370754599 | c.880C>T | p.Arg294Cys | p.R294C | Q6DKK2 | protein_coding | deleterious(0.04) | possibly_damaging(0.873) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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