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Gene: TSNAX |
Gene summary for TSNAX |
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Gene information | Species | Human | Gene symbol | TSNAX | Gene ID | 7257 |
Gene name | translin associated factor X | |
Gene Alias | C3PO | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R3V8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7257 | TSNAX | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.98e-03 | 1.08e-01 | 0.0155 |
7257 | TSNAX | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.88e-04 | 1.53e-01 | -0.1808 |
7257 | TSNAX | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.65e-01 | -0.0811 |
7257 | TSNAX | HTA11_78_2000001011 | Human | Colorectum | AD | 2.35e-06 | 2.42e-01 | -0.1088 |
7257 | TSNAX | HTA11_347_2000001011 | Human | Colorectum | AD | 5.91e-20 | 3.76e-01 | -0.1954 |
7257 | TSNAX | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 4.38e-01 | -0.2602 |
7257 | TSNAX | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.91e-05 | 1.91e-01 | -0.1207 |
7257 | TSNAX | HTA11_696_2000001011 | Human | Colorectum | AD | 9.63e-08 | 1.90e-01 | -0.1464 |
7257 | TSNAX | HTA11_866_2000001011 | Human | Colorectum | AD | 9.04e-05 | 1.27e-01 | -0.1001 |
7257 | TSNAX | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.00e-14 | 3.20e-01 | -0.059 |
7257 | TSNAX | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-08 | 4.22e-01 | -0.1706 |
7257 | TSNAX | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.60e-01 | -0.0179 |
7257 | TSNAX | HTA11_866_3004761011 | Human | Colorectum | AD | 2.32e-06 | 1.71e-01 | 0.096 |
7257 | TSNAX | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.80e-01 | 0.0446 |
7257 | TSNAX | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-06 | 3.09e-01 | 0.0131 |
7257 | TSNAX | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.21e-08 | 3.53e-01 | -0.0177 |
7257 | TSNAX | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 2.38e-01 | 0.0171 |
7257 | TSNAX | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.62e-06 | 1.93e-01 | 0.0338 |
7257 | TSNAX | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.63e-08 | 1.74e-01 | 0.0674 |
7257 | TSNAX | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.81e-02 | 2.45e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00905022 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 44/7305 | 82/18723 | 4.95e-03 | 1.94e-02 | 44 |
GO:00905014 | Skin | cSCC | RNA phosphodiester bond hydrolysis | 71/4864 | 152/18723 | 2.72e-08 | 7.41e-07 | 71 |
GO:00903054 | Skin | cSCC | nucleic acid phosphodiester bond hydrolysis | 97/4864 | 261/18723 | 4.08e-05 | 4.34e-04 | 97 |
GO:00905024 | Skin | cSCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 34/4864 | 82/18723 | 1.58e-03 | 9.75e-03 | 34 |
GO:00905015 | Thyroid | PTC | RNA phosphodiester bond hydrolysis | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
GO:00903055 | Thyroid | PTC | nucleic acid phosphodiester bond hydrolysis | 105/5968 | 261/18723 | 2.53e-03 | 1.31e-02 | 105 |
GO:009050112 | Thyroid | ATC | RNA phosphodiester bond hydrolysis | 76/6293 | 152/18723 | 2.07e-05 | 1.86e-04 | 76 |
GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSNAX | SNV | Missense_Mutation | c.184N>C | p.Asp62His | p.D62H | Q99598 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8620-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
TSNAX | SNV | Missense_Mutation | novel | c.441N>C | p.Glu147Asp | p.E147D | Q99598 | protein_coding | tolerated(0.11) | benign(0.061) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TSNAX | SNV | Missense_Mutation | novel | c.220N>A | p.Leu74Ile | p.L74I | Q99598 | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
TSNAX | SNV | Missense_Mutation | c.513N>T | p.Gln171His | p.Q171H | Q99598 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TSNAX | SNV | Missense_Mutation | c.170N>C | p.Val57Ala | p.V57A | Q99598 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TSNAX | SNV | Missense_Mutation | rs762657262 | c.665G>A | p.Arg222His | p.R222H | Q99598 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
TSNAX | insertion | Nonsense_Mutation | novel | c.366_367insAATTAATATTTGTAAAATGCTTATAACCCTGCTG | p.Gly123AsnfsTer2 | p.G123Nfs*2 | Q99598 | protein_coding | TCGA-VQ-AA64-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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