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Gene: TRPM8 |
Gene summary for TRPM8 |
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Gene information | Species | Human | Gene symbol | TRPM8 | Gene ID | 79054 |
Gene name | transient receptor potential cation channel subfamily M member 8 | |
Gene Alias | LTRPC6 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q7Z2W7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79054 | TRPM8 | HCC1 | Human | Liver | HCC | 6.61e-04 | 1.90e+00 | 0.5336 |
79054 | TRPM8 | HCC2 | Human | Liver | HCC | 2.58e-04 | 6.72e-01 | 0.5341 |
79054 | TRPM8 | HCC5 | Human | Liver | HCC | 1.63e-03 | 1.64e+00 | 0.4932 |
79054 | TRPM8 | S027 | Human | Liver | HCC | 3.60e-14 | 7.39e-01 | 0.2446 |
79054 | TRPM8 | S028 | Human | Liver | HCC | 4.21e-05 | 3.30e-01 | 0.2503 |
79054 | TRPM8 | S029 | Human | Liver | HCC | 6.22e-06 | 3.56e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
GO:010610611 | Liver | HCC | cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
GO:012016111 | Liver | HCC | regulation of cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
GO:199084511 | Liver | HCC | adaptive thermogenesis | 81/7958 | 157/18723 | 1.32e-02 | 4.72e-02 | 81 |
GO:000926615 | Prostate | Tumor | response to temperature stimulus | 59/3246 | 178/18723 | 2.14e-07 | 5.21e-06 | 59 |
GO:00094099 | Prostate | Tumor | response to cold | 17/3246 | 49/18723 | 2.61e-03 | 1.43e-02 | 17 |
GO:01201623 | Prostate | Tumor | positive regulation of cold-induced thermogenesis | 28/3246 | 97/18723 | 3.35e-03 | 1.74e-02 | 28 |
GO:19908453 | Prostate | Tumor | adaptive thermogenesis | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
GO:00016593 | Prostate | Tumor | temperature homeostasis | 44/3246 | 174/18723 | 5.04e-03 | 2.45e-02 | 44 |
GO:01061064 | Prostate | Tumor | cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
GO:01201614 | Prostate | Tumor | regulation of cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPM8 | SNV | Missense_Mutation | novel | c.11N>A | p.Arg4Gln | p.R4Q | Q7Z2W7 | protein_coding | tolerated_low_confidence(0.83) | benign(0) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRPM8 | SNV | Missense_Mutation | novel | c.2673N>C | p.Gln891His | p.Q891H | Q7Z2W7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRPM8 | SNV | Missense_Mutation | novel | c.3063C>G | p.Phe1021Leu | p.F1021L | Q7Z2W7 | protein_coding | tolerated(1) | benign(0.03) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRPM8 | SNV | Missense_Mutation | c.1765N>G | p.Leu589Val | p.L589V | Q7Z2W7 | protein_coding | tolerated(0.47) | benign(0.112) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRPM8 | SNV | Missense_Mutation | c.2907N>G | p.Ile969Met | p.I969M | Q7Z2W7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRPM8 | SNV | Missense_Mutation | rs140382067 | c.820N>A | p.Glu274Lys | p.E274K | Q7Z2W7 | protein_coding | deleterious(0.01) | possibly_damaging(0.604) | TCGA-ZJ-A8QO-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TRPM8 | SNV | Missense_Mutation | rs757061068 | c.356N>A | p.Arg119His | p.R119H | Q7Z2W7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRPM8 | SNV | Missense_Mutation | rs200473098 | c.65N>A | p.Arg22Gln | p.R22Q | Q7Z2W7 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TRPM8 | SNV | Missense_Mutation | rs765451235 | c.2186N>T | p.Ala729Val | p.A729V | Q7Z2W7 | protein_coding | deleterious(0.02) | benign(0.041) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TRPM8 | SNV | Missense_Mutation | rs758520683 | c.3023G>A | p.Arg1008His | p.R1008H | Q7Z2W7 | protein_coding | deleterious(0.01) | possibly_damaging(0.77) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135651503 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135649885 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 178100954 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 178101078 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135651438 | ANANDAMIDE | |
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | activator | 135651519 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | 354702247 | ELISMETREP | |
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | 404859145 | ||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | D3263 | |||
79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | MENTHOL | MENTHOL | 17293875 |
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