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Gene: TRIM44 |
Gene summary for TRIM44 |
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Gene information | Species | Human | Gene symbol | TRIM44 | Gene ID | 54765 |
Gene name | tripartite motif containing 44 | |
Gene Alias | AN3 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q96DX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54765 | TRIM44 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.23e-03 | -2.27e-01 | 0.3005 |
54765 | TRIM44 | A015-C-203 | Human | Colorectum | FAP | 1.47e-26 | -2.67e-01 | -0.1294 |
54765 | TRIM44 | A002-C-201 | Human | Colorectum | FAP | 6.86e-07 | -2.35e-01 | 0.0324 |
54765 | TRIM44 | A002-C-203 | Human | Colorectum | FAP | 3.19e-03 | -3.52e-02 | 0.2786 |
54765 | TRIM44 | A001-C-108 | Human | Colorectum | FAP | 5.31e-16 | -9.39e-02 | -0.0272 |
54765 | TRIM44 | A002-C-205 | Human | Colorectum | FAP | 1.40e-12 | -1.79e-01 | -0.1236 |
54765 | TRIM44 | A015-C-006 | Human | Colorectum | FAP | 1.92e-08 | -4.53e-02 | -0.0994 |
54765 | TRIM44 | A015-C-106 | Human | Colorectum | FAP | 1.55e-07 | -1.11e-01 | -0.0511 |
54765 | TRIM44 | A002-C-114 | Human | Colorectum | FAP | 2.07e-10 | -1.76e-01 | -0.1561 |
54765 | TRIM44 | A015-C-104 | Human | Colorectum | FAP | 1.70e-24 | -1.22e-01 | -0.1899 |
54765 | TRIM44 | A001-C-014 | Human | Colorectum | FAP | 1.38e-10 | -2.03e-01 | 0.0135 |
54765 | TRIM44 | A002-C-016 | Human | Colorectum | FAP | 3.34e-14 | -2.17e-01 | 0.0521 |
54765 | TRIM44 | A015-C-002 | Human | Colorectum | FAP | 9.57e-06 | -2.46e-01 | -0.0763 |
54765 | TRIM44 | A001-C-203 | Human | Colorectum | FAP | 2.75e-04 | -5.66e-02 | -0.0481 |
54765 | TRIM44 | A002-C-116 | Human | Colorectum | FAP | 6.10e-25 | -3.19e-01 | -0.0452 |
54765 | TRIM44 | A014-C-008 | Human | Colorectum | FAP | 1.98e-05 | -2.51e-01 | -0.191 |
54765 | TRIM44 | A018-E-020 | Human | Colorectum | FAP | 6.66e-12 | -1.29e-01 | -0.2034 |
54765 | TRIM44 | F034 | Human | Colorectum | FAP | 1.08e-16 | -1.11e-01 | -0.0665 |
54765 | TRIM44 | F072B | Human | Colorectum | FAP | 2.06e-06 | -1.66e-01 | 0.257 |
54765 | TRIM44 | CRC-1-8810 | Human | Colorectum | CRC | 1.51e-02 | -6.78e-02 | 0.6257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00316472 | Colorectum | MSS | regulation of protein stability | 103/3467 | 298/18723 | 2.52e-11 | 3.49e-09 | 103 |
GO:19033202 | Colorectum | MSS | regulation of protein modification by small protein conjugation or removal | 82/3467 | 242/18723 | 7.49e-09 | 4.63e-07 | 82 |
GO:00508212 | Colorectum | MSS | protein stabilization | 68/3467 | 191/18723 | 1.53e-08 | 8.81e-07 | 68 |
GO:00313962 | Colorectum | MSS | regulation of protein ubiquitination | 70/3467 | 210/18723 | 1.88e-07 | 8.26e-06 | 70 |
GO:00313972 | Colorectum | MSS | negative regulation of protein ubiquitination | 33/3467 | 83/18723 | 5.08e-06 | 1.40e-04 | 33 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:19033212 | Colorectum | MSS | negative regulation of protein modification by small protein conjugation or removal | 36/3467 | 95/18723 | 7.10e-06 | 1.82e-04 | 36 |
GO:00709361 | Colorectum | MSS | protein K48-linked ubiquitination | 27/3467 | 65/18723 | 1.40e-05 | 3.18e-04 | 27 |
GO:19033204 | Colorectum | FAP | regulation of protein modification by small protein conjugation or removal | 61/2622 | 242/18723 | 2.36e-06 | 9.21e-05 | 61 |
GO:00508214 | Colorectum | FAP | protein stabilization | 51/2622 | 191/18723 | 2.63e-06 | 9.96e-05 | 51 |
GO:00709362 | Colorectum | FAP | protein K48-linked ubiquitination | 24/2622 | 65/18723 | 3.42e-06 | 1.23e-04 | 24 |
GO:00002093 | Colorectum | FAP | protein polyubiquitination | 59/2622 | 236/18723 | 4.53e-06 | 1.52e-04 | 59 |
GO:00316474 | Colorectum | FAP | regulation of protein stability | 70/2622 | 298/18723 | 6.60e-06 | 2.04e-04 | 70 |
GO:00313964 | Colorectum | FAP | regulation of protein ubiquitination | 50/2622 | 210/18723 | 9.03e-05 | 1.59e-03 | 50 |
GO:00313974 | Colorectum | FAP | negative regulation of protein ubiquitination | 23/2622 | 83/18723 | 7.96e-04 | 8.36e-03 | 23 |
GO:19033214 | Colorectum | FAP | negative regulation of protein modification by small protein conjugation or removal | 25/2622 | 95/18723 | 1.10e-03 | 1.06e-02 | 25 |
GO:00508215 | Colorectum | CRC | protein stabilization | 44/2078 | 191/18723 | 1.77e-06 | 8.92e-05 | 44 |
GO:19033205 | Colorectum | CRC | regulation of protein modification by small protein conjugation or removal | 51/2078 | 242/18723 | 4.55e-06 | 1.87e-04 | 51 |
GO:00313975 | Colorectum | CRC | negative regulation of protein ubiquitination | 24/2078 | 83/18723 | 7.18e-06 | 2.67e-04 | 24 |
GO:19033215 | Colorectum | CRC | negative regulation of protein modification by small protein conjugation or removal | 26/2078 | 95/18723 | 9.16e-06 | 3.19e-04 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM44 | insertion | Frame_Shift_Ins | novel | c.84_85insGCCGAGGAAGTGT | p.Glu35GlyfsTer42 | p.E35Gfs*42 | Q96DX7 | protein_coding | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRIM44 | insertion | Frame_Shift_Ins | novel | c.760_761insA | p.Met255AsnfsTer10 | p.M255Nfs*10 | Q96DX7 | protein_coding | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
TRIM44 | insertion | Frame_Shift_Ins | novel | c.936dupA | p.Ala313SerfsTer6 | p.A313Sfs*6 | Q96DX7 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRIM44 | SNV | Missense_Mutation | c.949N>G | p.Leu317Val | p.L317V | Q96DX7 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
TRIM44 | SNV | Missense_Mutation | novel | c.711G>T | p.Leu237Phe | p.L237F | Q96DX7 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-55-7910-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TRIM44 | SNV | Missense_Mutation | novel | c.1024N>A | p.Glu342Lys | p.E342K | Q96DX7 | protein_coding | tolerated_low_confidence(0.07) | benign(0.038) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
TRIM44 | SNV | Missense_Mutation | c.771G>A | p.Met257Ile | p.M257I | Q96DX7 | protein_coding | tolerated(0.18) | benign(0) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
TRIM44 | SNV | Missense_Mutation | novel | c.163C>T | p.His55Tyr | p.H55Y | Q96DX7 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-43-8118-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
TRIM44 | SNV | Missense_Mutation | novel | c.641C>T | p.Thr214Ile | p.T214I | Q96DX7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-J1-A4AH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
TRIM44 | SNV | Missense_Mutation | novel | c.820N>A | p.Glu274Lys | p.E274K | Q96DX7 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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