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Gene: TPBG |
Gene summary for TPBG |
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Gene information | Species | Human | Gene symbol | TPBG | Gene ID | 7162 |
Gene name | trophoblast glycoprotein | |
Gene Alias | 5T4 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q13641 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7162 | TPBG | CA_HPV_1 | Human | Cervix | CC | 4.13e-06 | -1.81e-01 | 0.0264 |
7162 | TPBG | Tumor | Human | Cervix | CC | 3.60e-08 | 3.67e-01 | 0.1241 |
7162 | TPBG | sample3 | Human | Cervix | CC | 1.18e-28 | 5.35e-01 | 0.1387 |
7162 | TPBG | T1 | Human | Cervix | CC | 9.41e-03 | 2.32e-01 | 0.0918 |
7162 | TPBG | T2 | Human | Cervix | CC | 8.51e-05 | 4.18e-01 | 0.0709 |
7162 | TPBG | T3 | Human | Cervix | CC | 7.66e-23 | 5.21e-01 | 0.1389 |
7162 | TPBG | AEH-subject1 | Human | Endometrium | AEH | 1.71e-04 | -3.12e-01 | -0.3059 |
7162 | TPBG | AEH-subject2 | Human | Endometrium | AEH | 6.46e-09 | -3.19e-01 | -0.2525 |
7162 | TPBG | AEH-subject3 | Human | Endometrium | AEH | 6.10e-09 | -3.88e-01 | -0.2576 |
7162 | TPBG | AEH-subject4 | Human | Endometrium | AEH | 5.98e-07 | -3.61e-01 | -0.2657 |
7162 | TPBG | AEH-subject5 | Human | Endometrium | AEH | 2.77e-10 | -4.41e-01 | -0.2953 |
7162 | TPBG | EEC-subject1 | Human | Endometrium | EEC | 1.14e-14 | -3.72e-01 | -0.2682 |
7162 | TPBG | EEC-subject2 | Human | Endometrium | EEC | 6.51e-12 | -4.10e-01 | -0.2607 |
7162 | TPBG | EEC-subject3 | Human | Endometrium | EEC | 4.98e-17 | -3.94e-01 | -0.2525 |
7162 | TPBG | EEC-subject4 | Human | Endometrium | EEC | 2.97e-05 | -3.55e-01 | -0.2571 |
7162 | TPBG | EEC-subject5 | Human | Endometrium | EEC | 2.25e-09 | -3.87e-01 | -0.249 |
7162 | TPBG | GSM5276934 | Human | Endometrium | EEC | 1.23e-02 | -1.27e-01 | -0.0913 |
7162 | TPBG | GSM5276935 | Human | Endometrium | EEC | 7.46e-07 | -3.45e-01 | -0.123 |
7162 | TPBG | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.52e-22 | -4.23e-01 | -0.1869 |
7162 | TPBG | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.01e-20 | -4.16e-01 | -0.1875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00603267 | Cervix | CC | cell chemotaxis | 73/2311 | 310/18723 | 2.82e-08 | 1.96e-06 | 73 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00509203 | Cervix | CC | regulation of chemotaxis | 51/2311 | 223/18723 | 8.03e-06 | 1.86e-04 | 51 |
GO:00434104 | Cervix | CC | positive regulation of MAPK cascade | 90/2311 | 480/18723 | 2.92e-05 | 4.83e-04 | 90 |
GO:00509213 | Cervix | CC | positive regulation of chemotaxis | 34/2311 | 141/18723 | 8.19e-05 | 1.11e-03 | 34 |
GO:00518964 | Cervix | CC | regulation of protein kinase B signaling | 39/2311 | 185/18723 | 5.25e-04 | 5.10e-03 | 39 |
GO:19018886 | Cervix | CC | regulation of cell junction assembly | 42/2311 | 204/18723 | 5.50e-04 | 5.29e-03 | 42 |
GO:00518973 | Cervix | CC | positive regulation of protein kinase B signaling | 28/2311 | 120/18723 | 5.90e-04 | 5.59e-03 | 28 |
GO:00434913 | Cervix | CC | protein kinase B signaling | 43/2311 | 211/18723 | 5.95e-04 | 5.60e-03 | 43 |
GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPBG | SNV | Missense_Mutation | c.1133N>A | p.Arg378His | p.R378H | Q13641 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
TPBG | SNV | Missense_Mutation | c.266N>A | p.Leu89Gln | p.L89Q | Q13641 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TPBG | SNV | Missense_Mutation | c.907N>A | p.Ala303Thr | p.A303T | Q13641 | protein_coding | tolerated(0.19) | benign(0) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
TPBG | SNV | Missense_Mutation | c.401G>A | p.Arg134His | p.R134H | Q13641 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TPBG | SNV | Missense_Mutation | c.889N>A | p.Val297Ile | p.V297I | Q13641 | protein_coding | tolerated(0.06) | benign(0.138) | TCGA-46-3765-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TPBG | SNV | Missense_Mutation | novel | c.812N>T | p.Lys271Met | p.K271M | Q13641 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
TPBG | SNV | Missense_Mutation | c.1094N>C | p.Leu365Pro | p.L365P | Q13641 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TPBG | SNV | Missense_Mutation | c.1186A>T | p.Met396Leu | p.M396L | Q13641 | protein_coding | tolerated(0.17) | benign(0.056) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
TPBG | SNV | Missense_Mutation | rs759290440 | c.884N>T | p.Pro295Leu | p.P295L | Q13641 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TPBG | SNV | Missense_Mutation | novel | c.166N>A | p.Pro56Thr | p.P56T | Q13641 | protein_coding | deleterious(0.01) | benign(0.047) | TCGA-HC-8266-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | CHEMBL1743045 | NAPTUMOMAB ESTAFENATOX | ||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | antibody | 374883834 | ||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | CHEMBL2108248 | ANATUMOMAB MAFENATOX | ||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | PF-06263507 | PF-06263507 | ||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | Naptumomab estafenatox | |||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | CV-9201 | |||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | TroVax | TROVAX | ||
7162 | TPBG | CELL SURFACE, DRUGGABLE GENOME | antibody | 374883835 |
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