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Gene: TMTC3 |
Gene summary for TMTC3 |
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Gene information | Species | Human | Gene symbol | TMTC3 | Gene ID | 160418 |
Gene name | transmembrane O-mannosyltransferase targeting cadherins 3 | |
Gene Alias | LIS8 | |
Cytomap | 12q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A8K321 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
160418 | TMTC3 | LZE2T | Human | Esophagus | ESCC | 3.15e-07 | 6.74e-01 | 0.082 |
160418 | TMTC3 | LZE4T | Human | Esophagus | ESCC | 7.81e-20 | 6.80e-01 | 0.0811 |
160418 | TMTC3 | LZE7T | Human | Esophagus | ESCC | 1.04e-04 | 5.83e-01 | 0.0667 |
160418 | TMTC3 | LZE8T | Human | Esophagus | ESCC | 1.78e-04 | 3.42e-01 | 0.067 |
160418 | TMTC3 | LZE24T | Human | Esophagus | ESCC | 1.26e-10 | 2.47e-01 | 0.0596 |
160418 | TMTC3 | P1T-E | Human | Esophagus | ESCC | 1.46e-03 | 3.35e-01 | 0.0875 |
160418 | TMTC3 | P2T-E | Human | Esophagus | ESCC | 1.06e-59 | 9.07e-01 | 0.1177 |
160418 | TMTC3 | P4T-E | Human | Esophagus | ESCC | 4.04e-16 | 4.55e-01 | 0.1323 |
160418 | TMTC3 | P5T-E | Human | Esophagus | ESCC | 1.59e-10 | 2.45e-01 | 0.1327 |
160418 | TMTC3 | P8T-E | Human | Esophagus | ESCC | 4.05e-16 | 3.36e-01 | 0.0889 |
160418 | TMTC3 | P9T-E | Human | Esophagus | ESCC | 3.08e-08 | 2.08e-01 | 0.1131 |
160418 | TMTC3 | P10T-E | Human | Esophagus | ESCC | 2.89e-28 | 4.69e-01 | 0.116 |
160418 | TMTC3 | P11T-E | Human | Esophagus | ESCC | 7.91e-10 | 6.74e-01 | 0.1426 |
160418 | TMTC3 | P12T-E | Human | Esophagus | ESCC | 1.90e-18 | 3.78e-01 | 0.1122 |
160418 | TMTC3 | P15T-E | Human | Esophagus | ESCC | 9.54e-24 | 6.81e-01 | 0.1149 |
160418 | TMTC3 | P16T-E | Human | Esophagus | ESCC | 3.14e-15 | 3.27e-01 | 0.1153 |
160418 | TMTC3 | P20T-E | Human | Esophagus | ESCC | 5.28e-25 | 3.79e-01 | 0.1124 |
160418 | TMTC3 | P21T-E | Human | Esophagus | ESCC | 3.17e-35 | 7.95e-01 | 0.1617 |
160418 | TMTC3 | P22T-E | Human | Esophagus | ESCC | 2.68e-26 | 4.98e-01 | 0.1236 |
160418 | TMTC3 | P23T-E | Human | Esophagus | ESCC | 5.51e-23 | 6.75e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
GO:1901800110 | Esophagus | ESCC | positive regulation of proteasomal protein catabolic process | 91/8552 | 114/18723 | 6.74e-14 | 3.34e-12 | 91 |
GO:1903052110 | Esophagus | ESCC | positive regulation of proteolysis involved in cellular protein catabolic process | 101/8552 | 133/18723 | 9.58e-13 | 4.19e-11 | 101 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMTC3 | SNV | Missense_Mutation | rs768991210 | c.235N>T | p.Arg79Cys | p.R79C | Q6ZXV5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMTC3 | SNV | Missense_Mutation | novel | c.1759N>A | p.Leu587Ile | p.L587I | Q6ZXV5 | protein_coding | tolerated(0.24) | benign(0.019) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMTC3 | SNV | Missense_Mutation | c.1972N>A | p.Leu658Ile | p.L658I | Q6ZXV5 | protein_coding | tolerated(0.09) | possibly_damaging(0.846) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMTC3 | deletion | Frame_Shift_Del | c.2268delN | p.Lys758AsnfsTer31 | p.K758Nfs*31 | Q6ZXV5 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
TMTC3 | insertion | Frame_Shift_Ins | novel | c.2267_2268insA | p.Cys759MetfsTer3 | p.C759Mfs*3 | Q6ZXV5 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMTC3 | insertion | Frame_Shift_Ins | novel | c.1193_1194insA | p.Ser400LysfsTer4 | p.S400Kfs*4 | Q6ZXV5 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TMTC3 | insertion | Frame_Shift_Ins | novel | c.2267_2268insA | p.Cys759MetfsTer3 | p.C759Mfs*3 | Q6ZXV5 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
TMTC3 | SNV | Missense_Mutation | novel | c.692C>A | p.Ser231Tyr | p.S231Y | Q6ZXV5 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMTC3 | SNV | Missense_Mutation | rs747294917 | c.2725C>T | p.Arg909Cys | p.R909C | Q6ZXV5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMTC3 | SNV | Missense_Mutation | novel | c.168N>A | p.Phe56Leu | p.F56L | Q6ZXV5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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