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Gene: TMEM43 |
Gene summary for TMEM43 |
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Gene information | Species | Human | Gene symbol | TMEM43 | Gene ID | 79188 |
Gene name | transmembrane protein 43 | |
Gene Alias | ARVC5 | |
Cytomap | 3p25.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A0A024R2F9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79188 | TMEM43 | LZE2T | Human | Esophagus | ESCC | 4.16e-08 | 2.47e-01 | 0.082 |
79188 | TMEM43 | LZE4T | Human | Esophagus | ESCC | 4.49e-08 | 6.77e-02 | 0.0811 |
79188 | TMEM43 | LZE5T | Human | Esophagus | ESCC | 6.56e-04 | -4.55e-02 | 0.0514 |
79188 | TMEM43 | LZE7T | Human | Esophagus | ESCC | 2.46e-09 | 1.47e-01 | 0.0667 |
79188 | TMEM43 | LZE8T | Human | Esophagus | ESCC | 2.69e-03 | 1.81e-02 | 0.067 |
79188 | TMEM43 | LZE20T | Human | Esophagus | ESCC | 8.66e-08 | 6.39e-02 | 0.0662 |
79188 | TMEM43 | LZE21D1 | Human | Esophagus | HGIN | 4.33e-02 | 9.46e-02 | 0.0632 |
79188 | TMEM43 | LZE22D1 | Human | Esophagus | HGIN | 2.02e-03 | -6.72e-02 | 0.0595 |
79188 | TMEM43 | LZE24T | Human | Esophagus | ESCC | 8.12e-09 | 1.94e-01 | 0.0596 |
79188 | TMEM43 | LZE21T | Human | Esophagus | ESCC | 2.19e-04 | 1.81e-01 | 0.0655 |
79188 | TMEM43 | LZE6T | Human | Esophagus | ESCC | 1.27e-02 | 1.70e-01 | 0.0845 |
79188 | TMEM43 | P1T-E | Human | Esophagus | ESCC | 2.09e-06 | 1.95e-01 | 0.0875 |
79188 | TMEM43 | P2T-E | Human | Esophagus | ESCC | 1.10e-16 | 2.39e-01 | 0.1177 |
79188 | TMEM43 | P4T-E | Human | Esophagus | ESCC | 8.94e-18 | 4.28e-01 | 0.1323 |
79188 | TMEM43 | P5T-E | Human | Esophagus | ESCC | 2.45e-24 | 6.17e-01 | 0.1327 |
79188 | TMEM43 | P8T-E | Human | Esophagus | ESCC | 1.64e-15 | 1.79e-01 | 0.0889 |
79188 | TMEM43 | P9T-E | Human | Esophagus | ESCC | 1.40e-27 | 2.06e-01 | 0.1131 |
79188 | TMEM43 | P10T-E | Human | Esophagus | ESCC | 9.62e-27 | 4.03e-01 | 0.116 |
79188 | TMEM43 | P11T-E | Human | Esophagus | ESCC | 1.15e-20 | 6.80e-01 | 0.1426 |
79188 | TMEM43 | P12T-E | Human | Esophagus | ESCC | 2.02e-32 | 6.42e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069975 | Esophagus | HGIN | nucleus organization | 34/2587 | 133/18723 | 2.20e-04 | 4.00e-03 | 34 |
GO:00717634 | Esophagus | HGIN | nuclear membrane organization | 12/2587 | 33/18723 | 9.97e-04 | 1.25e-02 | 12 |
GO:00069983 | Esophagus | HGIN | nuclear envelope organization | 14/2587 | 47/18723 | 3.49e-03 | 3.23e-02 | 14 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:000699811 | Esophagus | ESCC | nuclear envelope organization | 39/8552 | 47/18723 | 1.48e-07 | 2.35e-06 | 39 |
GO:007176312 | Esophagus | ESCC | nuclear membrane organization | 29/8552 | 33/18723 | 5.30e-07 | 7.04e-06 | 29 |
GO:0006997 | Liver | Cirrhotic | nucleus organization | 48/4634 | 133/18723 | 2.27e-03 | 1.38e-02 | 48 |
GO:0071763 | Liver | Cirrhotic | nuclear membrane organization | 15/4634 | 33/18723 | 7.61e-03 | 3.60e-02 | 15 |
GO:00717631 | Liver | HCC | nuclear membrane organization | 27/7958 | 33/18723 | 4.31e-06 | 5.50e-05 | 27 |
GO:00069971 | Liver | HCC | nucleus organization | 82/7958 | 133/18723 | 6.32e-06 | 7.72e-05 | 82 |
GO:0006998 | Liver | HCC | nuclear envelope organization | 34/7958 | 47/18723 | 3.27e-05 | 3.29e-04 | 34 |
GO:00069974 | Oral cavity | OSCC | nucleus organization | 85/7305 | 133/18723 | 5.12e-09 | 1.12e-07 | 85 |
GO:00717633 | Oral cavity | OSCC | nuclear membrane organization | 29/7305 | 33/18723 | 8.40e-09 | 1.76e-07 | 29 |
GO:00069982 | Oral cavity | OSCC | nuclear envelope organization | 37/7305 | 47/18723 | 3.19e-08 | 6.12e-07 | 37 |
GO:007176311 | Oral cavity | LP | nuclear membrane organization | 18/4623 | 33/18723 | 2.26e-04 | 2.41e-03 | 18 |
GO:00069981 | Oral cavity | LP | nuclear envelope organization | 23/4623 | 47/18723 | 2.74e-04 | 2.84e-03 | 23 |
GO:000699712 | Oral cavity | LP | nucleus organization | 51/4623 | 133/18723 | 3.22e-04 | 3.26e-03 | 51 |
GO:00069972 | Prostate | BPH | nucleus organization | 38/3107 | 133/18723 | 3.69e-04 | 2.72e-03 | 38 |
GO:000699711 | Prostate | Tumor | nucleus organization | 38/3246 | 133/18723 | 8.78e-04 | 5.89e-03 | 38 |
GO:00069976 | Skin | cSCC | nucleus organization | 62/4864 | 133/18723 | 2.21e-07 | 4.72e-06 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM43 | SNV | Missense_Mutation | novel | c.133N>T | p.Leu45Phe | p.L45F | Q9BTV4 | protein_coding | tolerated(0.24) | benign(0.188) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM43 | SNV | Missense_Mutation | novel | c.509C>A | p.Pro170His | p.P170H | Q9BTV4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CQ-6220-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMEM43 | SNV | Missense_Mutation | novel | c.773N>T | p.Ala258Val | p.A258V | Q9BTV4 | protein_coding | tolerated(0.09) | possibly_damaging(0.583) | TCGA-CH-5769-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
TMEM43 | SNV | Missense_Mutation | c.572N>C | p.Phe191Ser | p.F191S | Q9BTV4 | protein_coding | tolerated(0.42) | benign(0.009) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM43 | SNV | Missense_Mutation | c.193N>C | p.Ala65Pro | p.A65P | Q9BTV4 | protein_coding | deleterious(0.05) | benign(0.175) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM43 | SNV | Missense_Mutation | c.440A>G | p.Tyr147Cys | p.Y147C | Q9BTV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
TMEM43 | SNV | Missense_Mutation | novel | c.665N>A | p.Gly222Glu | p.G222E | Q9BTV4 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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