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Gene: TMEM260 |
Gene summary for TMEM260 |
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Gene information | Species | Human | Gene symbol | TMEM260 | Gene ID | 54916 |
Gene name | transmembrane protein 260 | |
Gene Alias | C14orf101 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B3KN73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54916 | TMEM260 | H2 | Human | Cervix | HSIL_HPV | 6.28e-32 | 9.74e-01 | 0.0632 |
54916 | TMEM260 | LZE4T | Human | Esophagus | ESCC | 2.36e-15 | 2.91e-01 | 0.0811 |
54916 | TMEM260 | LZE5T | Human | Esophagus | ESCC | 1.29e-02 | 2.16e-01 | 0.0514 |
54916 | TMEM260 | LZE24T | Human | Esophagus | ESCC | 5.14e-11 | 2.69e-01 | 0.0596 |
54916 | TMEM260 | LZE21T | Human | Esophagus | ESCC | 3.94e-06 | 2.64e-01 | 0.0655 |
54916 | TMEM260 | P2T-E | Human | Esophagus | ESCC | 1.62e-12 | 2.35e-01 | 0.1177 |
54916 | TMEM260 | P4T-E | Human | Esophagus | ESCC | 3.77e-18 | 3.57e-01 | 0.1323 |
54916 | TMEM260 | P5T-E | Human | Esophagus | ESCC | 3.52e-10 | 1.14e-01 | 0.1327 |
54916 | TMEM260 | P8T-E | Human | Esophagus | ESCC | 1.16e-17 | 2.66e-01 | 0.0889 |
54916 | TMEM260 | P9T-E | Human | Esophagus | ESCC | 2.27e-07 | 1.79e-01 | 0.1131 |
54916 | TMEM260 | P10T-E | Human | Esophagus | ESCC | 1.05e-26 | 5.14e-01 | 0.116 |
54916 | TMEM260 | P11T-E | Human | Esophagus | ESCC | 7.79e-09 | 3.14e-01 | 0.1426 |
54916 | TMEM260 | P12T-E | Human | Esophagus | ESCC | 3.58e-24 | 4.61e-01 | 0.1122 |
54916 | TMEM260 | P15T-E | Human | Esophagus | ESCC | 1.49e-32 | 6.78e-01 | 0.1149 |
54916 | TMEM260 | P16T-E | Human | Esophagus | ESCC | 2.29e-17 | 2.98e-01 | 0.1153 |
54916 | TMEM260 | P19T-E | Human | Esophagus | ESCC | 3.68e-03 | 2.47e-01 | 0.1662 |
54916 | TMEM260 | P20T-E | Human | Esophagus | ESCC | 5.50e-08 | 1.97e-01 | 0.1124 |
54916 | TMEM260 | P21T-E | Human | Esophagus | ESCC | 3.42e-12 | 2.23e-01 | 0.1617 |
54916 | TMEM260 | P22T-E | Human | Esophagus | ESCC | 7.21e-19 | 2.10e-01 | 0.1236 |
54916 | TMEM260 | P23T-E | Human | Esophagus | ESCC | 5.08e-20 | 4.38e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM260 | SNV | Missense_Mutation | rs760776987 | c.1945N>T | p.Arg649Trp | p.R649W | Q9NX78 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | novel | c.1005C>A | p.Phe335Leu | p.F335L | Q9NX78 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | novel | c.747G>T | p.Trp249Cys | p.W249C | Q9NX78 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | rs764193089 | c.1096G>A | p.Val366Ile | p.V366I | Q9NX78 | protein_coding | tolerated(0.11) | benign(0.127) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | novel | c.1510A>G | p.Thr504Ala | p.T504A | Q9NX78 | protein_coding | tolerated(0.29) | benign(0.012) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | novel | c.1778G>T | p.Arg593Met | p.R593M | Q9NX78 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | rs748665207 | c.1711N>A | p.Glu571Lys | p.E571K | Q9NX78 | protein_coding | deleterious(0.03) | possibly_damaging(0.709) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM260 | SNV | Missense_Mutation | rs747674520 | c.883N>A | p.Glu295Lys | p.E295K | Q9NX78 | protein_coding | tolerated(0.11) | benign(0.026) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TMEM260 | SNV | Missense_Mutation | c.451N>A | p.Leu151Ile | p.L151I | Q9NX78 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM260 | SNV | Missense_Mutation | novel | c.872N>G | p.Asn291Ser | p.N291S | Q9NX78 | protein_coding | tolerated(0.67) | benign(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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