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Gene: TMEM215 |
Gene summary for TMEM215 |
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Gene information | Species | Human | Gene symbol | TMEM215 | Gene ID | 401498 |
Gene name | transmembrane protein 215 | |
Gene Alias | TMEM215 | |
Cytomap | 9p21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q68D42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401498 | TMEM215 | male-WTA | Human | Thyroid | PTC | 6.38e-17 | 2.65e-01 | 0.1037 |
401498 | TMEM215 | PTC01 | Human | Thyroid | PTC | 2.56e-04 | 1.59e-01 | 0.1899 |
401498 | TMEM215 | PTC06 | Human | Thyroid | PTC | 3.64e-11 | 5.11e-01 | 0.2057 |
401498 | TMEM215 | PTC07 | Human | Thyroid | PTC | 3.57e-20 | 5.87e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM215 | SNV | Missense_Mutation | rs762294471 | c.122N>T | p.Pro41Leu | p.P41L | Q68D42 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM215 | SNV | Missense_Mutation | novel | c.571N>A | p.Glu191Lys | p.E191K | Q68D42 | protein_coding | tolerated_low_confidence(0.43) | benign(0.031) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM215 | SNV | Missense_Mutation | c.503N>T | p.Ser168Leu | p.S168L | Q68D42 | protein_coding | tolerated(0.15) | probably_damaging(0.995) | TCGA-BB-A6UO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMEM215 | SNV | Missense_Mutation | novel | c.441G>T | p.Gln147His | p.Q147H | Q68D42 | protein_coding | deleterious(0.05) | benign(0) | TCGA-CV-A45Q-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM215 | SNV | Missense_Mutation | c.163G>A | p.Ala55Thr | p.A55T | Q68D42 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
TMEM215 | SNV | Missense_Mutation | c.325N>A | p.Asp109Asn | p.D109N | Q68D42 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-D7-6518-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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