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Gene: TMEM161B |
Gene summary for TMEM161B |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM161B | Gene ID | 153396 |
Gene name | transmembrane protein 161B | |
Gene Alias | FLB3342 | |
Cytomap | 5q14.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z6T3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153396 | TMEM161B | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.18e-12 | -4.80e-01 | 0.0155 |
153396 | TMEM161B | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.49e-04 | -4.43e-01 | -0.1808 |
153396 | TMEM161B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-06 | -5.15e-01 | -0.1207 |
153396 | TMEM161B | HTA11_696_2000001011 | Human | Colorectum | AD | 3.02e-09 | -4.26e-01 | -0.1464 |
153396 | TMEM161B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.72e-08 | -4.18e-01 | -0.1001 |
153396 | TMEM161B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.70e-07 | -4.50e-01 | -0.059 |
153396 | TMEM161B | HTA11_866_3004761011 | Human | Colorectum | AD | 7.36e-08 | -4.52e-01 | 0.096 |
153396 | TMEM161B | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.00e-05 | -4.66e-01 | 0.0338 |
153396 | TMEM161B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.25e-08 | -4.07e-01 | 0.0674 |
153396 | TMEM161B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.12e-06 | -3.85e-01 | 0.294 |
153396 | TMEM161B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.04e-09 | -3.95e-01 | 0.3859 |
153396 | TMEM161B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.49e-18 | -4.87e-01 | 0.3005 |
153396 | TMEM161B | A001-C-207 | Human | Colorectum | FAP | 5.59e-03 | -3.07e-01 | 0.1278 |
153396 | TMEM161B | A015-C-203 | Human | Colorectum | FAP | 7.17e-19 | -4.22e-01 | -0.1294 |
153396 | TMEM161B | A015-C-204 | Human | Colorectum | FAP | 2.84e-06 | -3.50e-01 | -0.0228 |
153396 | TMEM161B | A014-C-040 | Human | Colorectum | FAP | 2.17e-02 | -4.01e-01 | -0.1184 |
153396 | TMEM161B | A002-C-201 | Human | Colorectum | FAP | 7.00e-07 | -2.07e-01 | 0.0324 |
153396 | TMEM161B | A002-C-203 | Human | Colorectum | FAP | 9.91e-06 | -2.57e-01 | 0.2786 |
153396 | TMEM161B | A001-C-119 | Human | Colorectum | FAP | 5.46e-08 | -4.21e-01 | -0.1557 |
153396 | TMEM161B | A001-C-108 | Human | Colorectum | FAP | 5.65e-12 | -3.29e-01 | -0.0272 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM161B | SNV | Missense_Mutation | novel | c.298N>A | p.Tyr100Asn | p.Y100N | protein_coding | deleterious(0) | benign(0.101) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM161B | SNV | Missense_Mutation | c.295C>T | p.His99Tyr | p.H99Y | protein_coding | deleterious(0.01) | benign(0.044) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM161B | SNV | Missense_Mutation | rs746854349 | c.976N>T | p.Arg326Trp | p.R326W | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM161B | SNV | Missense_Mutation | c.52N>T | p.Met18Leu | p.M18L | protein_coding | tolerated(0.39) | benign(0) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
TMEM161B | SNV | Missense_Mutation | rs376651198 | c.944N>A | p.Arg315Gln | p.R315Q | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM161B | SNV | Missense_Mutation | novel | c.1138N>T | p.Ala380Ser | p.A380S | protein_coding | tolerated(0.08) | possibly_damaging(0.502) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMEM161B | SNV | Missense_Mutation | novel | c.1474N>C | p.Glu492Gln | p.E492Q | protein_coding | unknown(0) | TCGA-D1-A3DG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TMEM161B | SNV | Missense_Mutation | novel | c.79C>A | p.Leu27Ile | p.L27I | protein_coding | tolerated(0.09) | benign(0.055) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
TMEM161B | SNV | Missense_Mutation | novel | c.794N>A | p.Ile265Asn | p.I265N | protein_coding | tolerated(0.06) | possibly_damaging(0.596) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
TMEM161B | SNV | Missense_Mutation | novel | c.154N>A | p.Ala52Thr | p.A52T | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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