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Gene: TMEM135 |
Gene summary for TMEM135 |
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Gene information | Species | Human | Gene symbol | TMEM135 | Gene ID | 65084 |
Gene name | transmembrane protein 135 | |
Gene Alias | PMP52 | |
Cytomap | 11q14.2 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q86UB9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65084 | TMEM135 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.88e-15 | -5.60e-01 | 0.0155 |
65084 | TMEM135 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.04e-04 | -4.64e-01 | -0.1207 |
65084 | TMEM135 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.21e-02 | -2.59e-01 | -0.1464 |
65084 | TMEM135 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.01e-03 | -6.26e-01 | -0.2061 |
65084 | TMEM135 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.39e-12 | -5.51e-01 | 0.096 |
65084 | TMEM135 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.40e-04 | -4.62e-01 | 0.0338 |
65084 | TMEM135 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.17e-07 | -4.45e-01 | 0.0674 |
65084 | TMEM135 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.03e-02 | -3.44e-01 | 0.0588 |
65084 | TMEM135 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.45e-07 | -3.38e-01 | 0.294 |
65084 | TMEM135 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.76e-14 | -4.83e-01 | 0.3859 |
65084 | TMEM135 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.31e-07 | -6.63e-01 | 0.2585 |
65084 | TMEM135 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.20e-17 | -5.44e-01 | 0.3005 |
65084 | TMEM135 | F007 | Human | Colorectum | FAP | 1.93e-02 | -2.50e-01 | 0.1176 |
65084 | TMEM135 | A002-C-010 | Human | Colorectum | FAP | 5.59e-05 | -2.15e-01 | 0.242 |
65084 | TMEM135 | A001-C-207 | Human | Colorectum | FAP | 1.62e-08 | -4.10e-01 | 0.1278 |
65084 | TMEM135 | A015-C-203 | Human | Colorectum | FAP | 2.09e-34 | -5.67e-01 | -0.1294 |
65084 | TMEM135 | A015-C-204 | Human | Colorectum | FAP | 2.89e-09 | -3.74e-01 | -0.0228 |
65084 | TMEM135 | A014-C-040 | Human | Colorectum | FAP | 6.17e-09 | -6.78e-01 | -0.1184 |
65084 | TMEM135 | A002-C-201 | Human | Colorectum | FAP | 5.46e-20 | -5.06e-01 | 0.0324 |
65084 | TMEM135 | A002-C-203 | Human | Colorectum | FAP | 1.11e-05 | -2.10e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
GO:00108212 | Colorectum | MSS | regulation of mitochondrion organization | 53/3467 | 144/18723 | 1.67e-07 | 7.55e-06 | 53 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00094092 | Colorectum | MSS | response to cold | 19/3467 | 49/18723 | 7.20e-04 | 7.70e-03 | 19 |
GO:00316673 | Colorectum | FAP | response to nutrient levels | 95/2622 | 474/18723 | 1.59e-04 | 2.43e-03 | 95 |
GO:00108213 | Colorectum | FAP | regulation of mitochondrion organization | 35/2622 | 144/18723 | 6.44e-04 | 7.05e-03 | 35 |
GO:00094093 | Colorectum | FAP | response to cold | 14/2622 | 49/18723 | 5.95e-03 | 3.75e-02 | 14 |
GO:00316678 | Lung | IAC | response to nutrient levels | 76/2061 | 474/18723 | 4.87e-04 | 7.08e-03 | 76 |
GO:003166713 | Lung | AIS | response to nutrient levels | 64/1849 | 474/18723 | 6.13e-03 | 4.98e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM135 | SNV | Missense_Mutation | novel | c.1262G>A | p.Arg421Gln | p.R421Q | Q86UB9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TMEM135 | insertion | Frame_Shift_Ins | novel | c.1002_1003insT | p.Leu336PhefsTer10 | p.L336Ffs*10 | Q86UB9 | protein_coding | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD | ||
TMEM135 | insertion | In_Frame_Ins | novel | c.346_347insACT | p.Ile116delinsAsnPhe | p.I116delinsNF | Q86UB9 | protein_coding | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM135 | insertion | Frame_Shift_Ins | novel | c.358dupA | p.Ser120LysfsTer65 | p.S120Kfs*65 | Q86UB9 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM135 | SNV | Missense_Mutation | novel | c.383N>T | p.Tyr128Phe | p.Y128F | Q86UB9 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-DD-AACZ-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TMEM135 | SNV | Missense_Mutation | c.637C>T | p.His213Tyr | p.H213Y | Q86UB9 | protein_coding | deleterious(0.04) | benign(0.036) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM135 | SNV | Missense_Mutation | rs768976861 | c.880N>G | p.Asn294Asp | p.N294D | Q86UB9 | protein_coding | deleterious(0.03) | probably_damaging(0.958) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM135 | SNV | Missense_Mutation | c.695C>T | p.Ser232Leu | p.S232L | Q86UB9 | protein_coding | tolerated(0.23) | benign(0.071) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM135 | SNV | Missense_Mutation | novel | c.397N>T | p.Ala133Ser | p.A133S | Q86UB9 | protein_coding | deleterious(0.01) | possibly_damaging(0.57) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM135 | SNV | Missense_Mutation | c.1342N>T | p.Thr448Ser | p.T448S | Q86UB9 | protein_coding | tolerated(0.67) | benign(0) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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