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Gene: TMEM115 |
Gene summary for TMEM115 |
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Gene information | Species | Human | Gene symbol | TMEM115 | Gene ID | 11070 |
Gene name | transmembrane protein 115 | |
Gene Alias | PL6 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R2Y2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11070 | TMEM115 | LZE4T | Human | Esophagus | ESCC | 3.54e-02 | 3.19e-02 | 0.0811 |
11070 | TMEM115 | LZE7T | Human | Esophagus | ESCC | 3.91e-06 | 1.94e-01 | 0.0667 |
11070 | TMEM115 | LZE8T | Human | Esophagus | ESCC | 1.50e-04 | 6.00e-02 | 0.067 |
11070 | TMEM115 | LZE24T | Human | Esophagus | ESCC | 2.02e-17 | 4.68e-01 | 0.0596 |
11070 | TMEM115 | P2T-E | Human | Esophagus | ESCC | 1.24e-14 | 2.45e-01 | 0.1177 |
11070 | TMEM115 | P4T-E | Human | Esophagus | ESCC | 4.71e-17 | 2.80e-01 | 0.1323 |
11070 | TMEM115 | P5T-E | Human | Esophagus | ESCC | 1.56e-11 | 4.72e-02 | 0.1327 |
11070 | TMEM115 | P8T-E | Human | Esophagus | ESCC | 9.19e-18 | 1.45e-01 | 0.0889 |
11070 | TMEM115 | P9T-E | Human | Esophagus | ESCC | 3.19e-11 | 1.98e-01 | 0.1131 |
11070 | TMEM115 | P10T-E | Human | Esophagus | ESCC | 3.47e-24 | 2.93e-01 | 0.116 |
11070 | TMEM115 | P11T-E | Human | Esophagus | ESCC | 1.21e-12 | 5.55e-01 | 0.1426 |
11070 | TMEM115 | P12T-E | Human | Esophagus | ESCC | 7.46e-28 | 4.63e-01 | 0.1122 |
11070 | TMEM115 | P15T-E | Human | Esophagus | ESCC | 2.47e-09 | 2.26e-01 | 0.1149 |
11070 | TMEM115 | P16T-E | Human | Esophagus | ESCC | 5.12e-13 | 2.81e-01 | 0.1153 |
11070 | TMEM115 | P17T-E | Human | Esophagus | ESCC | 1.00e-03 | 2.61e-01 | 0.1278 |
11070 | TMEM115 | P19T-E | Human | Esophagus | ESCC | 2.27e-07 | 5.57e-01 | 0.1662 |
11070 | TMEM115 | P20T-E | Human | Esophagus | ESCC | 3.64e-20 | 3.78e-01 | 0.1124 |
11070 | TMEM115 | P21T-E | Human | Esophagus | ESCC | 1.43e-20 | 3.89e-01 | 0.1617 |
11070 | TMEM115 | P22T-E | Human | Esophagus | ESCC | 6.02e-27 | 3.77e-01 | 0.1236 |
11070 | TMEM115 | P23T-E | Human | Esophagus | ESCC | 2.98e-29 | 6.37e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000689017 | Esophagus | ESCC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 46/8552 | 52/18723 | 1.23e-10 | 3.66e-09 | 46 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:00068905 | Liver | Cirrhotic | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 29/4634 | 52/18723 | 1.69e-06 | 3.22e-05 | 29 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000689011 | Liver | HCC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 36/7958 | 52/18723 | 8.79e-05 | 7.66e-04 | 36 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:000689010 | Oral cavity | OSCC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 40/7305 | 52/18723 | 2.86e-08 | 5.50e-07 | 40 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000689018 | Skin | cSCC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/4864 | 52/18723 | 5.68e-05 | 5.67e-04 | 27 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:000689019 | Thyroid | PTC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 37/5968 | 52/18723 | 6.98e-09 | 1.75e-07 | 37 |
GO:0048193111 | Thyroid | ATC | Golgi vesicle transport | 189/6293 | 296/18723 | 9.58e-27 | 5.05e-24 | 189 |
GO:0006890110 | Thyroid | ATC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 37/6293 | 52/18723 | 3.45e-08 | 6.43e-07 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM115 | SNV | Missense_Mutation | novel | c.923A>G | p.Asp308Gly | p.D308G | Q12893 | protein_coding | tolerated(0.07) | benign(0.146) | TCGA-CR-7401-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM115 | SNV | Missense_Mutation | novel | c.611N>G | p.Tyr204Cys | p.Y204C | Q12893 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TMEM115 | insertion | Frame_Shift_Ins | novel | c.717_718insTACA | p.Ala240TyrfsTer55 | p.A240Yfs*55 | Q12893 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
TMEM115 | insertion | Frame_Shift_Ins | novel | c.716_717insAT | p.Ala240TrpfsTer10 | p.A240Wfs*10 | Q12893 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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