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Gene: TMEM106B |
Gene summary for TMEM106B |
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Gene information | Species | Human | Gene symbol | TMEM106B | Gene ID | 54664 |
Gene name | transmembrane protein 106B | |
Gene Alias | HLD16 | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R9Z1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54664 | TMEM106B | LZE4T | Human | Esophagus | ESCC | 2.09e-17 | 5.10e-01 | 0.0811 |
54664 | TMEM106B | LZE5T | Human | Esophagus | ESCC | 2.04e-05 | 5.68e-01 | 0.0514 |
54664 | TMEM106B | LZE7T | Human | Esophagus | ESCC | 7.27e-06 | 5.84e-01 | 0.0667 |
54664 | TMEM106B | LZE8T | Human | Esophagus | ESCC | 2.60e-04 | 2.88e-01 | 0.067 |
54664 | TMEM106B | LZE20T | Human | Esophagus | ESCC | 1.80e-02 | 1.54e-01 | 0.0662 |
54664 | TMEM106B | LZE22T | Human | Esophagus | ESCC | 6.92e-03 | 7.47e-01 | 0.068 |
54664 | TMEM106B | LZE24T | Human | Esophagus | ESCC | 3.69e-19 | 6.09e-01 | 0.0596 |
54664 | TMEM106B | LZE21T | Human | Esophagus | ESCC | 2.43e-02 | 6.48e-01 | 0.0655 |
54664 | TMEM106B | LZE6T | Human | Esophagus | ESCC | 2.22e-09 | 5.57e-01 | 0.0845 |
54664 | TMEM106B | P1T-E | Human | Esophagus | ESCC | 3.49e-15 | 6.61e-01 | 0.0875 |
54664 | TMEM106B | P2T-E | Human | Esophagus | ESCC | 2.78e-46 | 8.66e-01 | 0.1177 |
54664 | TMEM106B | P4T-E | Human | Esophagus | ESCC | 1.20e-31 | 7.83e-01 | 0.1323 |
54664 | TMEM106B | P5T-E | Human | Esophagus | ESCC | 1.73e-12 | 1.84e-01 | 0.1327 |
54664 | TMEM106B | P8T-E | Human | Esophagus | ESCC | 1.93e-28 | 4.13e-01 | 0.0889 |
54664 | TMEM106B | P9T-E | Human | Esophagus | ESCC | 9.92e-18 | 4.80e-01 | 0.1131 |
54664 | TMEM106B | P10T-E | Human | Esophagus | ESCC | 2.58e-40 | 8.02e-01 | 0.116 |
54664 | TMEM106B | P11T-E | Human | Esophagus | ESCC | 1.89e-25 | 1.09e+00 | 0.1426 |
54664 | TMEM106B | P12T-E | Human | Esophagus | ESCC | 6.99e-57 | 1.28e+00 | 0.1122 |
54664 | TMEM106B | P15T-E | Human | Esophagus | ESCC | 2.22e-35 | 7.59e-01 | 0.1149 |
54664 | TMEM106B | P16T-E | Human | Esophagus | ESCC | 1.27e-51 | 1.20e+00 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:00070403 | Esophagus | ESCC | lysosome organization | 53/8552 | 74/18723 | 5.34e-06 | 5.57e-05 | 53 |
GO:00801713 | Esophagus | ESCC | lytic vacuole organization | 53/8552 | 74/18723 | 5.34e-06 | 5.57e-05 | 53 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:00070353 | Esophagus | ESCC | vacuolar acidification | 20/8552 | 24/18723 | 1.69e-04 | 1.11e-03 | 20 |
GO:00070423 | Esophagus | ESCC | lysosomal lumen acidification | 11/8552 | 11/18723 | 1.80e-04 | 1.16e-03 | 11 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:004408812 | Esophagus | ESCC | regulation of vacuole organization | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:00070393 | Esophagus | ESCC | protein catabolic process in the vacuole | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:19051463 | Esophagus | ESCC | lysosomal protein catabolic process | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:00514521 | Esophagus | ESCC | intracellular pH reduction | 29/8552 | 42/18723 | 1.87e-03 | 8.46e-03 | 29 |
GO:00458511 | Esophagus | ESCC | pH reduction | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:00109764 | Esophagus | ESCC | positive regulation of neuron projection development | 91/8552 | 163/18723 | 5.72e-03 | 2.13e-02 | 91 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:000703411 | Liver | Cirrhotic | vacuolar transport | 75/4634 | 157/18723 | 3.13e-10 | 1.53e-08 | 75 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
GO:000704111 | Liver | Cirrhotic | lysosomal transport | 50/4634 | 114/18723 | 6.15e-06 | 9.82e-05 | 50 |
GO:0007040 | Liver | Cirrhotic | lysosome organization | 35/4634 | 74/18723 | 2.10e-05 | 2.77e-04 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM106B | SNV | Missense_Mutation | novel | c.203G>A | p.Gly68Glu | p.G68E | Q9NUM4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-68-8251-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
TMEM106B | insertion | Frame_Shift_Ins | novel | c.441_441+1insTACAGCTTTCT | p.Asn148TyrfsTer7 | p.N148Yfs*7 | Q9NUM4 | protein_coding | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
TMEM106B | SNV | Missense_Mutation | novel | c.297N>A | p.Met99Ile | p.M99I | Q9NUM4 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-CV-6945-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TMEM106B | SNV | Missense_Mutation | novel | c.46G>A | p.Asp16Asn | p.D16N | Q9NUM4 | protein_coding | tolerated(0.2) | benign(0.179) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM106B | SNV | Missense_Mutation | novel | c.608N>C | p.Ile203Thr | p.I203T | Q9NUM4 | protein_coding | deleterious(0.01) | possibly_damaging(0.502) | TCGA-TP-A8TT-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
TMEM106B | SNV | Missense_Mutation | c.754G>A | p.Asp252Asn | p.D252N | Q9NUM4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM106B | SNV | Missense_Mutation | novel | c.297G>T | p.Met99Ile | p.M99I | Q9NUM4 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM106B | SNV | Missense_Mutation | rs761236016 | c.418C>T | p.Arg140Cys | p.R140C | Q9NUM4 | protein_coding | tolerated(0.1) | possibly_damaging(0.679) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM106B | SNV | Missense_Mutation | novel | c.281N>T | p.Thr94Ile | p.T94I | Q9NUM4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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