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Gene: TLE3 |
Gene summary for TLE3 |
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Gene information | Species | Human | Gene symbol | TLE3 | Gene ID | 7090 |
Gene name | TLE family member 3, transcriptional corepressor | |
Gene Alias | ESG | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q04726 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7090 | TLE3 | LZE2T | Human | Esophagus | ESCC | 4.43e-02 | 1.92e-01 | 0.082 |
7090 | TLE3 | LZE4T | Human | Esophagus | ESCC | 3.17e-03 | -4.09e-02 | 0.0811 |
7090 | TLE3 | LZE7T | Human | Esophagus | ESCC | 9.57e-08 | 1.44e-01 | 0.0667 |
7090 | TLE3 | LZE8T | Human | Esophagus | ESCC | 1.85e-03 | -4.52e-02 | 0.067 |
7090 | TLE3 | LZE20T | Human | Esophagus | ESCC | 7.41e-03 | -5.91e-02 | 0.0662 |
7090 | TLE3 | LZE22T | Human | Esophagus | ESCC | 2.73e-05 | 2.17e-01 | 0.068 |
7090 | TLE3 | LZE24T | Human | Esophagus | ESCC | 7.00e-12 | 2.83e-01 | 0.0596 |
7090 | TLE3 | LZE21T | Human | Esophagus | ESCC | 8.79e-06 | 2.46e-01 | 0.0655 |
7090 | TLE3 | LZE6T | Human | Esophagus | ESCC | 5.03e-03 | -3.54e-02 | 0.0845 |
7090 | TLE3 | P1T-E | Human | Esophagus | ESCC | 8.03e-08 | 7.32e-01 | 0.0875 |
7090 | TLE3 | P2T-E | Human | Esophagus | ESCC | 6.21e-32 | 6.18e-01 | 0.1177 |
7090 | TLE3 | P4T-E | Human | Esophagus | ESCC | 4.88e-15 | 3.26e-01 | 0.1323 |
7090 | TLE3 | P5T-E | Human | Esophagus | ESCC | 6.57e-11 | -5.48e-02 | 0.1327 |
7090 | TLE3 | P8T-E | Human | Esophagus | ESCC | 1.99e-27 | 5.49e-01 | 0.0889 |
7090 | TLE3 | P9T-E | Human | Esophagus | ESCC | 3.35e-06 | 2.23e-01 | 0.1131 |
7090 | TLE3 | P10T-E | Human | Esophagus | ESCC | 3.28e-28 | 5.32e-01 | 0.116 |
7090 | TLE3 | P12T-E | Human | Esophagus | ESCC | 2.20e-26 | 4.97e-01 | 0.1122 |
7090 | TLE3 | P15T-E | Human | Esophagus | ESCC | 2.02e-27 | 6.28e-01 | 0.1149 |
7090 | TLE3 | P16T-E | Human | Esophagus | ESCC | 9.09e-21 | 4.69e-01 | 0.1153 |
7090 | TLE3 | P17T-E | Human | Esophagus | ESCC | 1.35e-05 | 1.20e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:00900905 | Esophagus | ESCC | negative regulation of canonical Wnt signaling pathway | 78/8552 | 137/18723 | 5.17e-03 | 1.95e-02 | 78 |
GO:01061066 | Esophagus | ESCC | cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
GO:01201616 | Esophagus | ESCC | regulation of cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:010610611 | Liver | HCC | cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
GO:012016111 | Liver | HCC | regulation of cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
GO:199084511 | Liver | HCC | adaptive thermogenesis | 81/7958 | 157/18723 | 1.32e-02 | 4.72e-02 | 81 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
GO:003011110 | Oral cavity | OSCC | regulation of Wnt signaling pathway | 165/7305 | 328/18723 | 1.87e-05 | 1.80e-04 | 165 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa043304 | Prostate | BPH | Notch signaling pathway | 21/1718 | 62/8465 | 8.53e-03 | 2.68e-02 | 1.66e-02 | 21 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0433011 | Prostate | BPH | Notch signaling pathway | 21/1718 | 62/8465 | 8.53e-03 | 2.68e-02 | 1.66e-02 | 21 |
hsa043302 | Prostate | Tumor | Notch signaling pathway | 22/1791 | 62/8465 | 6.45e-03 | 2.16e-02 | 1.34e-02 | 22 |
hsa0431023 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
hsa043303 | Prostate | Tumor | Notch signaling pathway | 22/1791 | 62/8465 | 6.45e-03 | 2.16e-02 | 1.34e-02 | 22 |
hsa0431033 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLE3 | SNV | Missense_Mutation | c.1474N>A | p.Val492Met | p.V492M | Q04726 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
TLE3 | SNV | Missense_Mutation | c.1859N>A | p.Gly620Glu | p.G620E | Q04726 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TLE3 | SNV | Missense_Mutation | c.1732N>A | p.Ala578Thr | p.A578T | Q04726 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TLE3 | SNV | Missense_Mutation | novel | c.1935N>T | p.Trp645Cys | p.W645C | Q04726 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TLE3 | insertion | Frame_Shift_Ins | novel | c.843_844insA | p.Asp282ArgfsTer14 | p.D282Rfs*14 | Q04726 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
TLE3 | SNV | Missense_Mutation | novel | c.655N>A | p.Asp219Asn | p.D219N | Q04726 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TLE3 | SNV | Missense_Mutation | c.1256N>T | p.Gly419Val | p.G419V | Q04726 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TLE3 | SNV | Missense_Mutation | novel | c.475N>A | p.Val159Met | p.V159M | Q04726 | protein_coding | tolerated(0.16) | possibly_damaging(0.492) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLE3 | SNV | Missense_Mutation | novel | c.2279C>A | p.Ser760Tyr | p.S760Y | Q04726 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLE3 | SNV | Missense_Mutation | novel | c.1733N>T | p.Ala578Val | p.A578V | Q04726 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7090 | TLE3 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR | DOCETAXEL | DOCETAXEL | ||
7090 | TLE3 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR | PACLITAXEL | PACLITAXEL |
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