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Gene: TLDC1 |
Gene summary for TLDC1 |
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Gene information | Species | Human | Gene symbol | TLDC1 | Gene ID | 57707 |
Gene name | MTOR associated protein, eak-7 homolog | |
Gene Alias | EAK7 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | A8K5C2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57707 | TLDC1 | P1T-E | Human | Esophagus | ESCC | 2.12e-03 | 1.80e-01 | 0.0875 |
57707 | TLDC1 | P2T-E | Human | Esophagus | ESCC | 4.86e-07 | 1.87e-01 | 0.1177 |
57707 | TLDC1 | P4T-E | Human | Esophagus | ESCC | 1.88e-08 | 2.50e-01 | 0.1323 |
57707 | TLDC1 | P5T-E | Human | Esophagus | ESCC | 3.91e-13 | 2.73e-01 | 0.1327 |
57707 | TLDC1 | P8T-E | Human | Esophagus | ESCC | 3.22e-14 | 1.98e-01 | 0.0889 |
57707 | TLDC1 | P9T-E | Human | Esophagus | ESCC | 7.37e-04 | 9.14e-02 | 0.1131 |
57707 | TLDC1 | P10T-E | Human | Esophagus | ESCC | 5.79e-03 | 5.93e-02 | 0.116 |
57707 | TLDC1 | P11T-E | Human | Esophagus | ESCC | 3.22e-06 | 3.12e-01 | 0.1426 |
57707 | TLDC1 | P12T-E | Human | Esophagus | ESCC | 1.51e-07 | 1.24e-01 | 0.1122 |
57707 | TLDC1 | P15T-E | Human | Esophagus | ESCC | 1.60e-12 | 3.23e-01 | 0.1149 |
57707 | TLDC1 | P16T-E | Human | Esophagus | ESCC | 5.93e-03 | 8.85e-02 | 0.1153 |
57707 | TLDC1 | P17T-E | Human | Esophagus | ESCC | 8.79e-05 | 3.64e-01 | 0.1278 |
57707 | TLDC1 | P20T-E | Human | Esophagus | ESCC | 3.40e-10 | 2.62e-01 | 0.1124 |
57707 | TLDC1 | P21T-E | Human | Esophagus | ESCC | 2.32e-24 | 5.29e-01 | 0.1617 |
57707 | TLDC1 | P22T-E | Human | Esophagus | ESCC | 5.01e-13 | 2.45e-01 | 0.1236 |
57707 | TLDC1 | P23T-E | Human | Esophagus | ESCC | 2.63e-15 | 4.20e-01 | 0.108 |
57707 | TLDC1 | P24T-E | Human | Esophagus | ESCC | 3.83e-11 | 2.73e-01 | 0.1287 |
57707 | TLDC1 | P26T-E | Human | Esophagus | ESCC | 2.92e-08 | 2.29e-01 | 0.1276 |
57707 | TLDC1 | P27T-E | Human | Esophagus | ESCC | 4.37e-08 | 1.39e-01 | 0.1055 |
57707 | TLDC1 | P28T-E | Human | Esophagus | ESCC | 1.08e-02 | 1.24e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLDC1 | SNV | Missense_Mutation | novel | c.1091A>C | p.Gln364Pro | p.Q364P | Q6P9B6 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLDC1 | SNV | Missense_Mutation | novel | c.1073N>A | p.Gly358Glu | p.G358E | Q6P9B6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLDC1 | SNV | Missense_Mutation | c.1296N>T | p.Glu432Asp | p.E432D | Q6P9B6 | protein_coding | deleterious(0.03) | benign(0.082) | TCGA-75-7031-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | c.916G>T | p.Gly306Trp | p.G306W | Q6P9B6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-91-6849-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | c.289C>T | p.His97Tyr | p.H97Y | Q6P9B6 | protein_coding | tolerated(0.34) | benign(0) | TCGA-22-4593-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | c.1076N>C | p.Leu359Pro | p.L359P | Q6P9B6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-34-5232-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | novel | c.680T>A | p.Leu227Gln | p.L227Q | Q6P9B6 | protein_coding | deleterious(0.04) | possibly_damaging(0.584) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TLDC1 | SNV | Missense_Mutation | novel | c.1331N>T | p.Arg444Leu | p.R444L | Q6P9B6 | protein_coding | tolerated(0.52) | benign(0.011) | TCGA-77-7338-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TLDC1 | deletion | Frame_Shift_Del | novel | c.372delA | p.Glu125LysfsTer17 | p.E125Kfs*17 | Q6P9B6 | protein_coding | TCGA-56-6545-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TLDC1 | SNV | Missense_Mutation | novel | c.907N>T | p.Val303Leu | p.V303L | Q6P9B6 | protein_coding | deleterious(0.03) | benign(0.261) | TCGA-CV-7407-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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