![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TIMM17B |
Gene summary for TIMM17B |
![]() |
Gene information | Species | Human | Gene symbol | TIMM17B | Gene ID | 10245 |
Gene name | translocase of inner mitochondrial membrane 17B | |
Gene Alias | DXS9822 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | O60830 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10245 | TIMM17B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.23e-04 | 1.07e-01 | 0.0155 |
10245 | TIMM17B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.86e-10 | 2.51e-01 | -0.1808 |
10245 | TIMM17B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-09 | 2.60e-01 | -0.0811 |
10245 | TIMM17B | HTA11_78_2000001011 | Human | Colorectum | AD | 6.68e-05 | 1.52e-01 | -0.1088 |
10245 | TIMM17B | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.04e-01 | -0.1954 |
10245 | TIMM17B | HTA11_411_2000001011 | Human | Colorectum | SER | 1.86e-06 | 3.87e-01 | -0.2602 |
10245 | TIMM17B | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 3.51e-01 | -0.2196 |
10245 | TIMM17B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 1.86e-01 | -0.1207 |
10245 | TIMM17B | HTA11_83_2000001011 | Human | Colorectum | SER | 2.92e-07 | 2.29e-01 | -0.1526 |
10245 | TIMM17B | HTA11_696_2000001011 | Human | Colorectum | AD | 7.69e-09 | 2.64e-01 | -0.1464 |
10245 | TIMM17B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.76e-02 | 1.36e-01 | -0.1001 |
10245 | TIMM17B | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.44e-13 | 3.16e-01 | -0.059 |
10245 | TIMM17B | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.23e-01 | -0.1706 |
10245 | TIMM17B | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 1.99e-01 | -0.2061 |
10245 | TIMM17B | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.20e-01 | -0.1462 |
10245 | TIMM17B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.83e-01 | -0.0842 |
10245 | TIMM17B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 1.73e-01 | 0.096 |
10245 | TIMM17B | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.05e-04 | 2.47e-01 | -0.0177 |
10245 | TIMM17B | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.62e-06 | 1.96e-01 | 0.0338 |
10245 | TIMM17B | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.22e-04 | 1.94e-01 | 0.0674 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
GO:00718061 | Colorectum | SER | protein transmembrane transport | 17/2897 | 59/18723 | 6.64e-03 | 4.69e-02 | 17 |
GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
Page: 1 2 3 4 5 6 7 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM17B | insertion | Frame_Shift_Ins | novel | c.509dupG | p.Ile171HisfsTer7 | p.I171Hfs*7 | O60830 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TIMM17B | insertion | Frame_Shift_Ins | rs782500597 | c.362_363insG | p.Leu122ProfsTer56 | p.L122Pfs*56 | O60830 | protein_coding | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
TIMM17B | insertion | Frame_Shift_Ins | rs782500597 | c.362_363insG | p.Leu122ProfsTer56 | p.L122Pfs*56 | O60830 | protein_coding | TCGA-PG-A6IB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TIMM17B | SNV | Missense_Mutation | c.80N>T | p.Gly27Val | p.G27V | O60830 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-05-4430-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TIMM17B | SNV | Missense_Mutation | novel | c.606C>A | p.Ser202Arg | p.S202R | O60830 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-55-6970-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
TIMM17B | SNV | Missense_Mutation | novel | c.632N>A | p.Pro211Gln | p.P211Q | O60830 | protein_coding | tolerated(0.05) | benign(0.028) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TIMM17B | SNV | Missense_Mutation | c.277N>C | p.Gly93Arg | p.G93R | O60830 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-34-5240-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TIMM17B | SNV | Missense_Mutation | novel | c.361G>A | p.Gly121Ser | p.G121S | O60830 | protein_coding | deleterious(0.02) | probably_damaging(0.956) | TCGA-43-7658-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |