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Gene: THEMIS2 |
Gene summary for THEMIS2 |
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Gene information | Species | Human | Gene symbol | THEMIS2 | Gene ID | 9473 |
Gene name | thymocyte selection associated family member 2 | |
Gene Alias | C1orf38 | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q5TEJ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9473 | THEMIS2 | male-WTA | Human | Thyroid | PTC | 2.18e-17 | 2.06e-01 | 0.1037 |
9473 | THEMIS2 | PTC01 | Human | Thyroid | PTC | 5.36e-03 | 1.01e-01 | 0.1899 |
9473 | THEMIS2 | PTC04 | Human | Thyroid | PTC | 2.16e-04 | 1.53e-01 | 0.1927 |
9473 | THEMIS2 | PTC05 | Human | Thyroid | PTC | 1.05e-10 | 6.85e-01 | 0.2065 |
9473 | THEMIS2 | PTC06 | Human | Thyroid | PTC | 1.87e-19 | 6.09e-01 | 0.2057 |
9473 | THEMIS2 | PTC07 | Human | Thyroid | PTC | 3.50e-12 | 2.34e-01 | 0.2044 |
9473 | THEMIS2 | ATC09 | Human | Thyroid | ATC | 8.63e-13 | 4.97e-01 | 0.2871 |
9473 | THEMIS2 | ATC12 | Human | Thyroid | ATC | 2.06e-02 | 3.58e-02 | 0.34 |
9473 | THEMIS2 | ATC1 | Human | Thyroid | ATC | 2.48e-12 | 5.39e-01 | 0.2878 |
9473 | THEMIS2 | ATC4 | Human | Thyroid | ATC | 3.66e-07 | 8.83e-02 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005085210 | Thyroid | PTC | T cell receptor signaling pathway | 52/5968 | 123/18723 | 9.58e-03 | 3.93e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THEMIS2 | SNV | Missense_Mutation | rs776304275 | c.650G>A | p.Arg217His | p.R217H | Q5TEJ8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
THEMIS2 | SNV | Missense_Mutation | c.1212G>T | p.Glu404Asp | p.E404D | Q5TEJ8 | protein_coding | tolerated(0.09) | benign(0.067) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THEMIS2 | SNV | Missense_Mutation | c.273N>C | p.Glu91Asp | p.E91D | Q5TEJ8 | protein_coding | tolerated(0.6) | benign(0.158) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THEMIS2 | SNV | Missense_Mutation | rs192452720 | c.871N>A | p.Val291Ile | p.V291I | Q5TEJ8 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THEMIS2 | SNV | Missense_Mutation | rs755193654 | c.1714G>A | p.Val572Ile | p.V572I | Q5TEJ8 | protein_coding | tolerated(0.28) | benign(0) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
THEMIS2 | SNV | Missense_Mutation | c.469N>A | p.Leu157Met | p.L157M | Q5TEJ8 | protein_coding | deleterious(0.03) | probably_damaging(0.93) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THEMIS2 | SNV | Missense_Mutation | novel | c.673N>C | p.Ser225Pro | p.S225P | Q5TEJ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
THEMIS2 | SNV | Missense_Mutation | novel | c.1588N>A | p.Glu530Lys | p.E530K | Q5TEJ8 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
THEMIS2 | SNV | Missense_Mutation | novel | c.1006N>T | p.Asp336Tyr | p.D336Y | Q5TEJ8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THEMIS2 | SNV | Missense_Mutation | novel | c.1327N>A | p.Ala443Thr | p.A443T | Q5TEJ8 | protein_coding | tolerated(0.46) | benign(0.435) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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