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Gene: TFEC |
Gene summary for TFEC |
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Gene information | Species | Human | Gene symbol | TFEC | Gene ID | 22797 |
Gene name | transcription factor EC | |
Gene Alias | TCFEC | |
Cytomap | 7q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O14948 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22797 | TFEC | Pt14.d | Human | Liver | HCC | 4.03e-02 | 1.54e-01 | 0.0143 |
22797 | TFEC | S027 | Human | Liver | HCC | 2.78e-14 | 1.01e+00 | 0.2446 |
22797 | TFEC | S028 | Human | Liver | HCC | 6.14e-17 | 8.54e-01 | 0.2503 |
22797 | TFEC | S029 | Human | Liver | HCC | 2.50e-18 | 5.76e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003460512 | Liver | HCC | cellular response to heat | 53/7958 | 69/18723 | 6.62e-09 | 1.70e-07 | 53 |
GO:000940811 | Liver | HCC | response to heat | 76/7958 | 110/18723 | 1.48e-08 | 3.58e-07 | 76 |
GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFEC | SNV | Missense_Mutation | c.797C>T | p.Thr266Ile | p.T266I | O14948 | protein_coding | tolerated(0.18) | benign(0.167) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TFEC | SNV | Missense_Mutation | novel | c.889N>A | p.Ala297Thr | p.A297T | O14948 | protein_coding | tolerated(0.23) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.641N>T | p.Arg214Met | p.R214M | O14948 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TFEC | SNV | Missense_Mutation | novel | c.1015N>C | p.Phe339Leu | p.F339L | O14948 | protein_coding | tolerated(0.1) | benign(0.011) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TFEC | SNV | Missense_Mutation | novel | c.392N>A | p.Thr131Asn | p.T131N | O14948 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TFEC | SNV | Missense_Mutation | rs766132159 | c.836N>T | p.Ala279Val | p.A279V | O14948 | protein_coding | tolerated(0.12) | benign(0.009) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.571N>C | p.Trp191Arg | p.W191R | O14948 | protein_coding | tolerated(0.82) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.396N>T | p.Arg132Ser | p.R132S | O14948 | protein_coding | deleterious(0) | benign(0.343) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.397N>A | p.Ala133Thr | p.A133T | O14948 | protein_coding | deleterious(0.02) | benign(0.029) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.784N>C | p.Cys262Arg | p.C262R | O14948 | protein_coding | tolerated(0.09) | possibly_damaging(0.691) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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