Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TEAD4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TEAD4_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TEAD4_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TEAD4_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TEAD4 | MYOEPI | Breast | Healthy | MMGT1,NAP1L5,RBBP8, etc. | 3.96e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TEAD4 | GC | Cervix | CC | ACKR1,AC006160.1,LRRC14, etc. | 8.71e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
TEAD4 | TAC | Colorectum | Healthy | PABPC4,GGT6,DARS2, etc. | 1.20e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TEAD4 | END | Colorectum | MSS | RHOJ,DNAJC18,SWT1, etc. | 4.50e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSS/regulons_activity_in_dotplot.png) |
TEAD4 | PFIB | Liver | Cirrhotic | COL5A3,ARHGAP23,LOXL2, etc. | 1.58e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_Cirrhotic/regulons_activity_in_dotplot.png) |
TEAD4 | AT1 | Lung | MIAC | DGKG,PLAC9,NCKAP5, etc. | 6.17e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
TEAD4 | ACINAR | Pancreas | ADJ | NFATC2,CTRL,SYCN, etc. | 3.22e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TEAD4 | ACINAR | Pancreas | PanIN | NFATC2,CTRL,SYCN, etc. | 4.21e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PanIN/regulons_activity_in_dotplot.png) |
TEAD4 | PVA | Prostate | BPH | VPS13A,SMURF2,LIN54, etc. | 3.98e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_BPH/regulons_activity_in_dotplot.png) |
TEAD4 | MVA | Prostate | Healthy | VPS13A,SMURF2,LIN54, etc. | 4.38e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEAD4 | SNV | Missense_Mutation | rs375587017 | c.191G>A | p.Arg64His | p.R64H | | protein_coding | deleterious(0) | possibly_damaging(0.85) | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TEAD4 | SNV | Missense_Mutation | rs527238579 | c.70N>A | p.Ala24Thr | p.A24T | | protein_coding | tolerated(0.57) | benign(0) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | | c.752N>A | p.Gly251Asp | p.G251D | | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | | c.67N>G | p.Thr23Ala | p.T23A | | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | rs369932433 | c.454N>T | p.Arg152Trp | p.R152W | | protein_coding | deleterious(0.02) | possibly_damaging(0.67) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | | c.230G>A | p.Arg77Gln | p.R77Q | | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TEAD4 | SNV | Missense_Mutation | | c.856N>A | p.Glu286Lys | p.E286K | | protein_coding | deleterious(0.03) | possibly_damaging(0.583) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | | c.1087N>T | p.Arg363Trp | p.R363W | | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | rs762656664 | c.787N>A | p.Glu263Lys | p.E263K | | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD4 | SNV | Missense_Mutation | novel | c.219N>T | p.Lys73Asn | p.K73N | | protein_coding | deleterious(0.01) | possibly_damaging(0.901) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |