![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TCN2 |
Gene summary for TCN2 |
![]() |
Gene information | Species | Human | Gene symbol | TCN2 | Gene ID | 6948 |
Gene name | transcobalamin 2 | |
Gene Alias | D22S676 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | P20062 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6948 | TCN2 | LZE7T | Human | Esophagus | ESCC | 5.52e-04 | 3.59e-01 | 0.0667 |
6948 | TCN2 | P1T-E | Human | Esophagus | ESCC | 4.51e-02 | 2.73e-01 | 0.0875 |
6948 | TCN2 | P4T-E | Human | Esophagus | ESCC | 5.55e-05 | 2.20e-01 | 0.1323 |
6948 | TCN2 | P8T-E | Human | Esophagus | ESCC | 1.18e-12 | 2.49e-01 | 0.0889 |
6948 | TCN2 | P10T-E | Human | Esophagus | ESCC | 4.65e-09 | 7.95e-02 | 0.116 |
6948 | TCN2 | P11T-E | Human | Esophagus | ESCC | 2.59e-08 | 4.74e-01 | 0.1426 |
6948 | TCN2 | P12T-E | Human | Esophagus | ESCC | 1.88e-03 | 3.63e-02 | 0.1122 |
6948 | TCN2 | P16T-E | Human | Esophagus | ESCC | 7.07e-05 | 1.11e-01 | 0.1153 |
6948 | TCN2 | P23T-E | Human | Esophagus | ESCC | 6.28e-03 | 2.29e-01 | 0.108 |
6948 | TCN2 | P24T-E | Human | Esophagus | ESCC | 4.77e-02 | 9.57e-02 | 0.1287 |
6948 | TCN2 | P26T-E | Human | Esophagus | ESCC | 5.88e-04 | 8.66e-02 | 0.1276 |
6948 | TCN2 | P27T-E | Human | Esophagus | ESCC | 2.53e-06 | 7.73e-02 | 0.1055 |
6948 | TCN2 | P30T-E | Human | Esophagus | ESCC | 5.60e-27 | 9.67e-01 | 0.137 |
6948 | TCN2 | P32T-E | Human | Esophagus | ESCC | 1.59e-03 | 7.86e-02 | 0.1666 |
6948 | TCN2 | P40T-E | Human | Esophagus | ESCC | 3.42e-08 | 3.22e-01 | 0.109 |
6948 | TCN2 | P47T-E | Human | Esophagus | ESCC | 1.05e-05 | 1.15e-01 | 0.1067 |
6948 | TCN2 | P52T-E | Human | Esophagus | ESCC | 1.15e-04 | 1.22e-01 | 0.1555 |
6948 | TCN2 | P57T-E | Human | Esophagus | ESCC | 3.91e-05 | 2.34e-01 | 0.0926 |
6948 | TCN2 | P65T-E | Human | Esophagus | ESCC | 1.50e-19 | 4.96e-01 | 0.0978 |
6948 | TCN2 | P74T-E | Human | Esophagus | ESCC | 5.06e-82 | 2.34e+00 | 0.1479 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00000411 | Liver | HCC | transition metal ion transport | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCN2 | SNV | Missense_Mutation | novel | c.112N>T | p.Leu38Phe | p.L38F | P20062 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCN2 | SNV | Missense_Mutation | c.160N>G | p.Ile54Val | p.I54V | P20062 | protein_coding | tolerated(0.29) | benign(0.015) | TCGA-LG-A6GG-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TCN2 | SNV | Missense_Mutation | rs200135085 | c.508N>T | p.Arg170Trp | p.R170W | P20062 | protein_coding | tolerated(0.05) | possibly_damaging(0.748) | TCGA-22-0944-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TCN2 | SNV | Missense_Mutation | c.289N>A | p.Gln97Lys | p.Q97K | P20062 | protein_coding | tolerated(0.06) | benign(0) | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
TCN2 | SNV | Missense_Mutation | novel | c.880N>T | p.Pro294Ser | p.P294S | P20062 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TCN2 | SNV | Missense_Mutation | novel | c.1085C>T | p.Ala362Val | p.A362V | P20062 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
TCN2 | SNV | Missense_Mutation | novel | c.408N>T | p.Glu136Asp | p.E136D | P20062 | protein_coding | deleterious(0.05) | probably_damaging(0.993) | TCGA-66-2742-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TCN2 | SNV | Missense_Mutation | rs367605153 | c.1168N>A | p.Gly390Arg | p.G390R | P20062 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-66-2767-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TCN2 | SNV | Missense_Mutation | novel | c.718N>C | p.Phe240Leu | p.F240L | P20062 | protein_coding | tolerated(0.13) | benign(0.346) | TCGA-77-6843-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TCN2 | SNV | Missense_Mutation | c.709N>A | p.Glu237Lys | p.E237K | P20062 | protein_coding | tolerated(0.09) | benign(0.094) | TCGA-77-7338-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |