TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TCFL5 | INCAF | Colorectum | ADJ | PARP6,ICA1,LINC00476, etc. | 1.00e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TCFL5 | ICAF | Colorectum | ADJ | PARP6,ICA1,LINC00476, etc. | 2.20e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TCFL5 | URO | Prostate | Tumor | CCL3L3,FAM134B,BMP3, etc. | 9.91e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Tumor/regulons_activity_in_dotplot.png) |
TCFL5 | SMC | Skin | cSCC | SCRN1,SERPINB1,TNS2, etc. | 1.51e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_cSCC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCFL5 | SNV | Missense_Mutation | rs767486884 | c.1042N>T | p.Arg348Cys | p.R348C | Q9UL49 | protein_coding | tolerated(0.06) | possibly_damaging(0.759) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TCFL5 | SNV | Missense_Mutation | rs779829916 | c.1043G>A | p.Arg348His | p.R348H | Q9UL49 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TCFL5 | SNV | Missense_Mutation | | c.1370N>T | p.Ser457Phe | p.S457F | Q9UL49 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TCFL5 | SNV | Missense_Mutation | | c.1370C>A | p.Ser457Tyr | p.S457Y | Q9UL49 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TCFL5 | SNV | Missense_Mutation | | c.1370C>A | p.Ser457Tyr | p.S457Y | Q9UL49 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCFL5 | SNV | Missense_Mutation | rs767486884 | c.1042N>T | p.Arg348Cys | p.R348C | Q9UL49 | protein_coding | tolerated(0.06) | possibly_damaging(0.759) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCFL5 | SNV | Missense_Mutation | novel | c.737C>A | p.Thr246Asn | p.T246N | Q9UL49 | protein_coding | deleterious(0.04) | benign(0.343) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCFL5 | SNV | Missense_Mutation | novel | c.1067G>A | p.Arg356Gln | p.R356Q | Q9UL49 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
TCFL5 | SNV | Missense_Mutation | novel | c.1358G>T | p.Arg453Ile | p.R453I | Q9UL49 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TCFL5 | SNV | Missense_Mutation | | c.1120G>A | p.Gly374Ser | p.G374S | Q9UL49 | protein_coding | tolerated(0.08) | benign(0.122) | TCGA-DD-A3A9-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |