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Gene: TBCC |
Gene summary for TBCC |
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Gene information | Species | Human | Gene symbol | TBCC | Gene ID | 6903 |
Gene name | tubulin folding cofactor C | |
Gene Alias | CFC | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q15814 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6903 | TBCC | LZE2T | Human | Esophagus | ESCC | 6.95e-06 | 9.29e-01 | 0.082 |
6903 | TBCC | LZE4T | Human | Esophagus | ESCC | 5.02e-13 | 3.61e-01 | 0.0811 |
6903 | TBCC | LZE7T | Human | Esophagus | ESCC | 1.18e-14 | 5.28e-01 | 0.0667 |
6903 | TBCC | LZE8T | Human | Esophagus | ESCC | 1.21e-09 | 2.32e-01 | 0.067 |
6903 | TBCC | LZE20T | Human | Esophagus | ESCC | 3.61e-09 | 3.22e-01 | 0.0662 |
6903 | TBCC | LZE22T | Human | Esophagus | ESCC | 1.61e-04 | 3.61e-01 | 0.068 |
6903 | TBCC | LZE24T | Human | Esophagus | ESCC | 4.19e-25 | 5.84e-01 | 0.0596 |
6903 | TBCC | LZE21T | Human | Esophagus | ESCC | 4.85e-07 | 3.24e-01 | 0.0655 |
6903 | TBCC | P1T-E | Human | Esophagus | ESCC | 4.25e-13 | 6.96e-01 | 0.0875 |
6903 | TBCC | P2T-E | Human | Esophagus | ESCC | 3.45e-21 | 4.93e-01 | 0.1177 |
6903 | TBCC | P4T-E | Human | Esophagus | ESCC | 3.76e-24 | 6.00e-01 | 0.1323 |
6903 | TBCC | P5T-E | Human | Esophagus | ESCC | 9.23e-16 | 3.75e-01 | 0.1327 |
6903 | TBCC | P8T-E | Human | Esophagus | ESCC | 6.06e-09 | 2.47e-01 | 0.0889 |
6903 | TBCC | P9T-E | Human | Esophagus | ESCC | 8.79e-14 | 2.97e-01 | 0.1131 |
6903 | TBCC | P10T-E | Human | Esophagus | ESCC | 1.12e-23 | 4.14e-01 | 0.116 |
6903 | TBCC | P11T-E | Human | Esophagus | ESCC | 1.04e-24 | 1.00e+00 | 0.1426 |
6903 | TBCC | P12T-E | Human | Esophagus | ESCC | 1.68e-25 | 5.60e-01 | 0.1122 |
6903 | TBCC | P15T-E | Human | Esophagus | ESCC | 3.25e-25 | 4.86e-01 | 0.1149 |
6903 | TBCC | P16T-E | Human | Esophagus | ESCC | 7.52e-25 | 5.05e-01 | 0.1153 |
6903 | TBCC | P17T-E | Human | Esophagus | ESCC | 5.93e-13 | 4.42e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165126 | Esophagus | HGIN | maintenance of location in cell | 53/2587 | 214/18723 | 1.22e-05 | 3.45e-04 | 53 |
GO:005123520 | Esophagus | HGIN | maintenance of location | 73/2587 | 327/18723 | 1.73e-05 | 4.71e-04 | 73 |
GO:00516455 | Esophagus | HGIN | Golgi localization | 7/2587 | 14/18723 | 1.34e-03 | 1.57e-02 | 7 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:00618428 | Esophagus | ESCC | microtubule organizing center localization | 28/8552 | 33/18723 | 3.80e-06 | 4.12e-05 | 28 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:00516428 | Esophagus | ESCC | centrosome localization | 27/8552 | 32/18723 | 7.10e-06 | 7.12e-05 | 27 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:005164512 | Esophagus | ESCC | Golgi localization | 11/8552 | 14/18723 | 1.30e-02 | 4.27e-02 | 11 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:0006457111 | Skin | cSCC | protein folding | 131/4864 | 212/18723 | 2.96e-28 | 1.32e-25 | 131 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBCC | SNV | Missense_Mutation | novel | c.172C>A | p.His58Asn | p.H58N | Q15814 | protein_coding | tolerated(0.1) | benign(0) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TBCC | SNV | Missense_Mutation | novel | c.499N>T | p.Asp167Tyr | p.D167Y | Q15814 | protein_coding | deleterious(0.04) | benign(0.232) | TCGA-44-A47B-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TBCC | SNV | Missense_Mutation | novel | c.171N>A | p.Ser57Arg | p.S57R | Q15814 | protein_coding | deleterious(0.04) | benign(0.023) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TBCC | SNV | Missense_Mutation | novel | c.1006N>G | p.Leu336Val | p.L336V | Q15814 | protein_coding | deleterious(0.01) | benign(0.215) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TBCC | SNV | Missense_Mutation | novel | c.17G>T | p.Cys6Phe | p.C6F | Q15814 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-56-A4BW-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
TBCC | insertion | Frame_Shift_Ins | novel | c.976_977insC | p.Arg326ProfsTer13 | p.R326Pfs*13 | Q15814 | protein_coding | TCGA-CV-6938-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TBCC | SNV | Missense_Mutation | novel | c.325N>T | p.Asp109Tyr | p.D109Y | Q15814 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-3M-AB46-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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