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Gene: TBC1D22B |
Gene summary for TBC1D22B |
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Gene information | Species | Human | Gene symbol | TBC1D22B | Gene ID | 55633 |
Gene name | TBC1 domain family member 22B | |
Gene Alias | C6orf197 | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NU19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55633 | TBC1D22B | LZE2T | Human | Esophagus | ESCC | 1.44e-03 | 3.79e-01 | 0.082 |
55633 | TBC1D22B | LZE7T | Human | Esophagus | ESCC | 1.60e-04 | 1.95e-01 | 0.0667 |
55633 | TBC1D22B | LZE24T | Human | Esophagus | ESCC | 5.05e-06 | 1.89e-01 | 0.0596 |
55633 | TBC1D22B | P2T-E | Human | Esophagus | ESCC | 2.48e-11 | 2.16e-01 | 0.1177 |
55633 | TBC1D22B | P4T-E | Human | Esophagus | ESCC | 7.55e-10 | 1.67e-01 | 0.1323 |
55633 | TBC1D22B | P5T-E | Human | Esophagus | ESCC | 4.45e-05 | 9.03e-02 | 0.1327 |
55633 | TBC1D22B | P8T-E | Human | Esophagus | ESCC | 4.74e-08 | 1.38e-01 | 0.0889 |
55633 | TBC1D22B | P9T-E | Human | Esophagus | ESCC | 1.01e-06 | 1.33e-01 | 0.1131 |
55633 | TBC1D22B | P10T-E | Human | Esophagus | ESCC | 7.30e-07 | 1.10e-01 | 0.116 |
55633 | TBC1D22B | P11T-E | Human | Esophagus | ESCC | 9.11e-06 | 2.44e-01 | 0.1426 |
55633 | TBC1D22B | P12T-E | Human | Esophagus | ESCC | 2.76e-04 | 1.58e-01 | 0.1122 |
55633 | TBC1D22B | P15T-E | Human | Esophagus | ESCC | 3.80e-09 | 1.89e-01 | 0.1149 |
55633 | TBC1D22B | P16T-E | Human | Esophagus | ESCC | 9.75e-08 | 1.12e-01 | 0.1153 |
55633 | TBC1D22B | P17T-E | Human | Esophagus | ESCC | 4.57e-04 | 2.48e-01 | 0.1278 |
55633 | TBC1D22B | P21T-E | Human | Esophagus | ESCC | 7.40e-04 | 1.20e-01 | 0.1617 |
55633 | TBC1D22B | P22T-E | Human | Esophagus | ESCC | 4.17e-10 | 8.72e-02 | 0.1236 |
55633 | TBC1D22B | P23T-E | Human | Esophagus | ESCC | 7.21e-12 | 2.20e-01 | 0.108 |
55633 | TBC1D22B | P24T-E | Human | Esophagus | ESCC | 2.27e-07 | 1.84e-01 | 0.1287 |
55633 | TBC1D22B | P26T-E | Human | Esophagus | ESCC | 2.92e-08 | 1.21e-01 | 0.1276 |
55633 | TBC1D22B | P27T-E | Human | Esophagus | ESCC | 4.05e-06 | 1.69e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
GO:00435475 | Lung | IAC | positive regulation of GTPase activity | 48/2061 | 255/18723 | 1.40e-04 | 2.60e-03 | 48 |
GO:00906303 | Lung | IAC | activation of GTPase activity | 22/2061 | 115/18723 | 6.80e-03 | 4.73e-02 | 22 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:004354711 | Lung | AIS | positive regulation of GTPase activity | 44/1849 | 255/18723 | 1.74e-04 | 3.64e-03 | 44 |
GO:009063011 | Lung | AIS | activation of GTPase activity | 21/1849 | 115/18723 | 4.07e-03 | 3.65e-02 | 21 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004354714 | Thyroid | PTC | positive regulation of GTPase activity | 103/5968 | 255/18723 | 2.38e-03 | 1.25e-02 | 103 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D22B | deletion | Frame_Shift_Del | c.524delN | p.Pro177GlnfsTer2 | p.P177Qfs*2 | Q9NU19 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
TBC1D22B | deletion | Frame_Shift_Del | c.530delC | p.Pro177GlnfsTer2 | p.P177Qfs*2 | Q9NU19 | protein_coding | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
TBC1D22B | SNV | Missense_Mutation | novel | c.358N>A | p.Asp120Asn | p.D120N | Q9NU19 | protein_coding | tolerated(0.46) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBC1D22B | SNV | Missense_Mutation | novel | c.878N>T | p.Arg293Ile | p.R293I | Q9NU19 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBC1D22B | SNV | Missense_Mutation | novel | c.696N>T | p.Glu232Asp | p.E232D | Q9NU19 | protein_coding | tolerated(0.67) | benign(0.03) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TBC1D22B | SNV | Missense_Mutation | c.111A>T | p.Lys37Asn | p.K37N | Q9NU19 | protein_coding | tolerated(0.19) | benign(0.142) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
TBC1D22B | SNV | Missense_Mutation | rs543514698 | c.767N>A | p.Arg256Gln | p.R256Q | Q9NU19 | protein_coding | tolerated(0.08) | possibly_damaging(0.608) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TBC1D22B | SNV | Missense_Mutation | rs778955950 | c.523N>C | p.Ala175Pro | p.A175P | Q9NU19 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D22B | SNV | Missense_Mutation | novel | c.1147C>T | p.Leu383Phe | p.L383F | Q9NU19 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TBC1D22B | SNV | Missense_Mutation | novel | c.344A>G | p.Gln115Arg | p.Q115R | Q9NU19 | protein_coding | tolerated(0.48) | benign(0.045) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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